Kudzala Mtengo Wathu wa Chiyembekezo -Positive Prevention Users Guide

by James Myhre ndi Dennis Sifris, MD, dokotala wodziwika bwino

Mankhwala Osakaniza Mankhwala Osakanikirana Amapereka Tsiku Limodzi, Mankhwala Okhaokha Amodzi

Kulemba

Complera ndi piritsi limodzi, mankhwala osakaniza omwe amagwiritsidwa ntchito pochiza HIV, omwe ali ndi ma antiretroviral atatu osiyanasiyana:

rilpivirine , osati nucleoside reverse transcriptase inhibitor (NNRTI)
emtricitabine, nucleotide reverse transcriptase inhibitor (NtrTI)
Tenofovir disoproxil fumarate (TDF), ina NtrTI

Complera inavomerezedwa ndi US Food and Drug Administration (FDA) pa August 10, 2011 kuti agwiritsidwe ntchito kwa akuluakulu ndi ana opitirira zaka khumi ndi ziwiri omwe sanakhalepo ndi kachilombo ka HIV , omwe ali ndi chiwerengero cha ma ARV 100,000 / m , ndi kulemera makilogalamu 35 kapena kuposa.

Complera ikhoza kugwiritsidwanso ntchito m'malo mwa chithandizo chamakono ngati wodwalayo ali ndi chiwerengero chosawoneka cha tizilombo (

Kupanga

Complera ndi piritsi yofiira, yomwe imakhala ndi mafilimu, yomwe ili ndi 25mg ya rilpivirine, 200mg ya emtricitabine ndi 300mg ya TDF. Ili ndi mawu akuti "GSI" kumbali imodzi ndipo ikudziwika bwino.

Mlingo

Phale limodzi tsiku ndi tsiku amatengedwa ndi chakudya. Complera sayenera kutengedwa ndi mankhwala ena opatsirana pogonana omwe amagwiritsidwa ntchito pochiza HIV.

Zotsatira Zotsatira

Zotsatira zochepa za mankhwala zakhala zikudziwika mu odwala ailesi odwala omwe amagwiritsa ntchito Complera, omwe ambiri mwa iwo anali:

Nausea
Mutu
Kusagona
Kusokonezeka maganizo

Zotsatira zake zimakhala zochepa, ndipo odwala ochepa amasiya chifukwa cha kusalana.

Contraindications

Complera sayenera kutengedwa ndi mankhwala awa kapena mankhwala owonjezera:

Mankhwala osokoneza bongo: Tegretol, Trilepta, phenobarbital, phenytoin
Mankhwala oletsa chifuwa chachikulu: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin

Proton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex kapena PPI ina iliyonse
Mankhwala a steroid: dexamethasone (ngakhale angaperekedwe pa mlingo umodzi ngati mankhwala akuwonetsedwa)
Wotchedwa St. John's Wort

Nthawi zonse muziwauza adokotala za mankhwala alionse kapena othandizira ena, omwe amawalamula kapena osapatsidwa, kuti mutengepo musanayambe mankhwala alionse ochepetsa kachilombo ka HIV.

Mfundo Zina

Complera sichivomerezedwa kwa odwala omwe ali ndi vuto la impso (lomwe limatanthauzidwa kuti ali ndi chidziwitso chachilengedwe chosachepera 30mL pa mphindi). Chonde funsani dokotala wanu ngati mwakhala kapena mukuchiritsidwa ndi matenda ena a impso ndi dokotala wina.

Pulogalamu ya complera sichivomerezeka kwa odwala matenda a chiwindi kapena omwe ali ndi matenda aakulu a chiwindi (hepatitis B) (HBV) momwe angayambitsire kwambiri vuto la chiwindi. Amalangizidwa kuti anthu omwe ali ndi kachirombo ka HIV ayang'anire HBV musanayambe kukonza Compreera. Chonde dalitsani dokotala ngati muli ndi vuto la chiwindi ndi / kapena mbiri ya chiwindi.

Chilombo cha rilpivirine chotchedwa Complera chingayambitse matenda opatsirana pogwiritsa ntchito ochepa odwala, kawirikawiri ngati kutukumuka, diso lakuda (maso a pinki), kutupa kwa nkhope, malungo, kapena mayankho ena. Kawirikawiri, kusintha kwa hypersensitivity kumakhala masabata 1-6 pambuyo pa kuyamba kwa mankhwala. Limbitsani dokotala mwamsanga za zizindikiro zoterezi zikuwonekera. Pa milandu yoopsa, mankhwalawa amafunika kuti asiye.

Chithandizo cha Kuchiza

Maumboni atsopano a Complera adavomerezedwa ndi FDA pa March 1, 2016, ogulitsidwa pansi pa dzina la Odefsey . Kukonzekera kwatsopano kumeneku kumalowetsa gawo la TDF ndi mankhwala otchedwa tenofovir alafenamide (TAF), omwe amamaliza ntchitoyi amatchulidwa ngati mankhwala osokoneza bongo.

Mosiyana ndi TDF, TAF ilibe mankhwala osokoneza bongo koma amagwiritsa ntchito thupi lokha lomwe limasintha kuti likhale mawonekedwe ake. Momwemonso, mankhwalawa amaperekedwa bwino kwambiri ku maselo omwe ali otsika kwambiri, komanso ndi mankhwala ochepetsa kwambiri mankhwala osokoneza bongo (makamaka ponena za kuwonongeka kwa impso zogwirizana ndi ntchito ya TDF).

_Zotsatira:

_{US Food and Drug Administration (FDA_.) "Kuvomerezeka kwa Complera: emtricitabine / rilpivirine / tenofovir DF yakhazikitsa mgwirizano wa mankhwala." Silver Srping, Maryland; inatulutsa August 10, 2011.}

_{Sciences la Gileadi.} _{"Complera - Mfundo Zazikulu Zopereka Mauthenga."} _{Foster City, California;} _{inapezeka pa March 18, 2016.}

_Reuters. _{"KUKHALA - Sciences Gileadi Inati US FDA Yavomereza Odefsey" Inatuluka pa March 1, 2015.}