Ofufuza akupeza vuto lomwe lingathe kupititsa ku AIDS zaka zitatu
Ngakhale palibe njira yomwe HIV imayambira kuchokera kwa munthu mmodzi kupita ku yotsatira, pali zovuta (zosiyana) zomwe zimakhudzidwa ndi kupita patsogolo mofulumira. Zosinthazi zimachokera ku kusintha kwa majini komwe kumayambira kumadera ena, ndipo nthawi zambiri imafalikira kudera lomwelo kuti likhale lalikulu kwambiri.
Kafukufuku wofalitsidwa m'nyuzipepala ya zachipatala EBioMedicine wanena kuti mitundu yosiyanasiyana yotereyi yakhala ikupezeka ku Cuba, yomwe imadziwika kuti ikukhala AIDS m'kati mwa zaka zitatu zoyamba kutenga kachilombo ka HIV.
Malingana ndi lipotili, ofufuza a ku yunivesite ya Leuven ku Belgium adapeza kuti vutoli ndi CRF19 , kachilombo ka HIV kamene kamakhala ndi kachigawo kakang'ono ka HIV, A, D, ndi G.
Pamene kachilombo ka HIV kamapita patsogolo ku AIDS m'zaka zisanu kapena khumi popanda mankhwala, CRF19 ikuwonekera mofulumira kwambiri poika munthu payekha pangozi ya matenda ndi imfa asanayambe kulandira chithandizo .
Zofufuza Zophunzira
Odwala makumi asanu ndi awiri anadziwika ndi ochita kafukufuku mofulumira (RP), poyerekeza ndi kuchepa kwa CD4 kuchuluka kwa maselo 200 / mL kapena kuwonetsa matenda a Edzi (kapena onse).
M'badwo wamkati wa odwala unali 34, pamene chiŵerengero cha CD4 panthawi yomwe anachidziŵika chinali 276 maselo / mL. Mosiyana ndi zimenezi, gulu lofanana la odwala kachilombo ka HIV popanda kusiyana kwa CRF19 linali ndi CD4 ya pakati pa 522 ndi 577 panthawi yomwe anazindikira.
Komanso, obwera patsogolo mofulumira anali ndi kachilombo ka HIV kamodzi kapena katatu kupitirira kuposa omwe sali ofulumira-kupita patsogolo.
Chifukwa chake, odwala omwe ali ndi CRF19 adatsimikiziridwa anali ndi nthawi yapakati pakati pa seroconversion ndi Edzi ya zaka 1.4 zokha poyerekeza ndi zaka 9.8 chifukwa cha anzawo omwe sanali CRF19.
Ndemanga za Kukula Kwamsanga
Ofufuzawo adatha kusiyanitsa zinthu zambiri zomwe zingakhale zikufotokozera kuwonjezeka kwa AIDS. Ponena za chiwerengero cha anthu, panali zozizwitsa zowonjezereka zogonana mofulumira kusiyana ndi anthu osapitilira mofulumira (49% vs 28%). Kuonjezera apo, palibe kusiyana pakati pa kupeza kachilombo ka HIV pogonana (ana, chikazi).
Malingana ndi zomwe apeza, ofufuzawo amakhulupirira kuti kusintha kofulumira kwa mtundu wa CRF19 kungathe kufotokozera zochitikazo.
Kawirikawiri, pali mitundu iŵiri ya co-receptors pamwamba pa maselo oyera a magazi omwe amalola kuti kulowa mu selo: CCR5 ndi CXCR4 . CCR5 ndi yokhala ndi kachilombo kamene kachirombo ka HIV kawirikawiri kakugwiritsira ntchito pa matenda oyambirira, pamene CXCR4 ndi yomwe imagwiritsidwa ntchito pamapeto pake.
Ndi mitundu ya CRF19, kachilomboka kamasintha kuchoka pogwiritsa ntchito CCR5 mpaka CXCR4 mofulumira kwambiri kusiyana ndi mavuto ena a HIV . Pochita zimenezi, chiwerengero cha matendawa chimathamangidwanso, zomwe zimapangitsa kuti asanamwalire msanga.
Zomwe zapezazi zidzafuna kuti chiwerengero cha HIV chiziwonjezereke ku Cuba, chomwe panopa chiri ndi chiwerengero cha 0.2% (poyerekeza ndi 0.9% ku US) ndi zikwi zisanu ndi chimodzi zokha zomwe zatsimikiziridwa.
Zomwe zili zokhudzana ndikuti, ndi nthawi yochuluka kuchokera ku matenda odwala matenda a matendawa kuyambira miyezi 37 mpaka miyezi 55, akuluakulu a zaumoyo sangathe kuzindikira anthu omwe ali ndi chiwerengero cha CRF19 mwamsanga kuti athe kufalitsa kachilombo ka HIV.
Ngakhale kuti mailesi a zachipatala atha kukhazikitsidwa pakadali pano, maikowa anali atachoka ku Cuba kuyambira 2005 mpaka mwina kuyambira ku Central Africa, komwe ku Angola, Burkina Faso, Cameroun, ndi ku Togo kunabwerezedwa milandu.
Zotsatira:
Khouri, V .; Khouri, R .; Alemán, Y .; et al. "CRF19_cpx ndi Kusinthika koyenera kwa HIV-1 Kusinthasintha Kwambiri Kwambiri ndi Kupita Mwamsanga kwa Edzi ku Cuba." EBioMedicine. January 28, 2015; lembani: 10.1016 / j.ebiom.2015.01.015.
Casado, G ;; Thomson, M .; Sierra, M .; et al. "Kudziwa kwa Buku Lopatulika HIV-1 Kuzungulira ADG Intersubtype Formula Recombinant (CRF19_cpx) ku Cuba." Journal of Deficiency Immune Deficiency Syndromes (JAMA). December 15, 2005; 40 (5): 532-537.
Garrido, C .; Zahonero, N .; Fernandés, D .; et al. "Kusiyana kwa chiwerengero cha mankhwala, kuyankhulana kwapadera ndi kusakaniza mankhwala osokoneza bongo pamatenda owuma omwe amachokera kwa odwala kachilombo ka HIV pa mankhwala opatsirana pogonana ku Angola." Journal of Antimicrobial Chemotherapy. January 24, 2008; 61 (3): 694-498.
Tebit, D .; Ganame, J .; Sathiandee, K .; et al. "Kusiyana kwa kachilombo ka HIV m'madera akumidzi ku Burkina Faso." JAMA. October 1, 2006; 43 (2): 144-152.
Machuca, A .; Tang, S.; Kutumiza, D .; et al. "Kusiyana kwa mitundu yosiyanasiyana ya ma Genetic ndi Intersubtype Recombinants of HIV-1 mu Magazi a Magazi Ochokera ku Mzinda wa Urban Cameroon." JAMA. July1, 2007; 45 (3): 361-363.
Yaotsè, D ;; Nicole, V; Fabien Roche, N .; et al. "Kuwonetsa kwa mitundu ya HIV-1 ku Togo kumatithandiza kudziwa kuti pali zinthu zambiri zomwe zimachititsa kuti anthu asamakhale ndi kachilombo koyambitsa matendawa." Matenda, Genetics ndi Evolution. July 2009; 9 (4): 646-652.