Amuna ndi abambo amatha kukhala ndi mafupa ambiri chifukwa cha ukalamba, ndi amayi achikulire omwe amatha kudwala matendawa . Mukakhala ndi mafupa okwanira komanso osauka bwino mafupa kuti mupeze matenda odwala matenda a mitsempha, thanzi lanu lonse ndi thanzi lanu liri pangozi.
Ngati mwapezeka kuti muli ndi matenda otupa mafupa, dziwani kuti sikuchedwa kwambiri kuti muthe kupititsa patsogolo mafupa anu ndi kuteteza kuphulika kumene kungayambitse kupweteka kosatha ndikulephera kuyenda nokha.
Njira zambiri zothandizira chithandizo zilipo, ndipo kafukufuku akuthandizira njira zatsopano monga Tymlos (abaloparatide).
Musanamvetse momwe mankhwala amathandizira, kufotokozera mwachidule za chithandizo kungakhale kothandiza.
Mankhwala Oseoporosis Amachokera pa Thupi Lanu Ntchito
Mankhwala ochizira matenda a m'mimba amagwiritsira ntchito ntchito yamtundu wanu. Mwinamwake mukudziwa kuti mafupa anu amagwira ntchito kuti mupereke thupi lanu. Chodabwitsa n'chakuti angathe kupereka chithandizochi kwa thupi lanu pamene akusintha nthawi zonse-ndondomeko yotchedwa remodeling.
Pali mitundu iwiri yapadera yamagulu m'mapfupa anu: amodzi amapanga fupa lanu (osteoblasts) ndipo lina limataya mafupa anu (osteoclasts). Thupi labwino lili ndi mgwirizano pakati pa ntchito za mitundu iwiriyi. Mankhwala ambiri odwala matenda a mitsempha amagwira ntchito poyang'anira ntchito ya maselowa pfupa lanu.
Mafupa anu ndi komwe thupi lanu limagwiritsira ntchito calcium, mineral yomwe ili yofunikira pa ubongo wanu ndi minofu, kuphatikizapo mtima wogwira ntchito.
Ngati ma calcium anu sali oyenerera muli pachiopsezo chachikulu cha mankhwala.
Monga machitidwe ambiri ofunika m'thupi lanu, pali hormone yotchedwa parathyroid hormone (PTH) imene imayesetsa kuti muyambe kuyendetsa thupi lanu. Kumvetsetsa mbali yaikulu ya hormone ya parathyroid yomwe ikuyenda mukutuluka kwa mafupa anu kumapangitsa ochita kafukufuku kukhala ndi mtundu wina wa mankhwala opatsirana osteoporosis.
Njira Yabwino Yothetsera Osteoporosis Yamphamvu
Gululi la mankhwala, malinga ndi ntchito ya PTH, amatchedwa PTH1 ligands. Abaloparartide (Tymlos) ndi mankhwala atsopano m'kalasi ili kupeza mgwirizano wa FDA wochizira matenda odwala matenda odwala matendawa.
Kodi Zimagwira Ntchito Bwanji?
Tymlos amachita ngati PTH, kumangiriza kwa imodzi ya mapulogalamu a PTH mu fupa lanu. Mtundu wa receptor womwe umamangiriza ndi momwe umamangiririra umalimbikitsa kupangidwira mafupa ndi kuchepetsanso ntchito zina za PTH, kutanthauza kupumitsa mafupa, ndi kutuluka kwa calcium.
Kodi Imachita Chiyani?
Tylmos yasonyezedwa kuti yowonjezera kukula kwa fupa lanu ndi fupa la mchere komanso kuti thupi lanu likhale lamphamvu mukatha kuchipatala.
Ndani Angatenge?
Ndi mankhwala othandiza, koma amakhala ndi zotsatira zoyipa. Phindu la Tylmos liyenera kukhala lolingana ndi zoopsa zake.
Pakalipano, mankhwalawa akusungira gulu la odwala omwe angakhale ndi phindu lalikulu, mokwanira kupitirira kuopsa kwa mankhwala. Tylmos ali ndi FDA akuvomerezedwa kuti athe kuchiza matenda odwala matenda odwala matenda odwala matenda a m'mimba mwa amayi omwe ali ndi matendawa:
- Mbiri ya kupasuka kwa osteoporotic
- Zowonjezera zowonjezera zomwe zimapangidwira fracture
- Mbiri yakale ya kumwa mankhwala ena omwe sanawathandize kapena omwe sangalekerere
Simungathe kutenga Tymlos ngati muli ndi vuto lina la mfupa kapena mavuto omwe mumakhala nawo.
Kodi Mumazitenga Bwanji?
Tymlos ayenera kutengedwa tsiku ndi tsiku. Amapezeka ngati jekeseni yomwe imatengedwa pansi pa khungu lanu. Mlingo woyenera tsiku lililonse ndi 80mcg. Muyenera kukhala otsimikiza kuti mukupeza calcium ndi vitamini D zokwanira mu zakudya zanu. Ngati simuli, muyenera kutenga zowonjezera .
Kodi Zotsatira Zilipo?
Mofanana ndi mankhwala onse, Tymlos ali ndi zotsatirapo. Zina mwa zotsatirazi ndi zofatsa pamene zina ndizovuta kwambiri. Zotsatira za Matendawa zimakhudzana ndi kusamvana kwa calcium ndipo zimaphatikizapo:
- Kashiki yowonjezera mu mkodzo wanu yomwe imayambitsa miyala ya impso
- Chizungulire
- Nausea
- Mutu
- Kukukwa kwa mtima kofulumira
- Kutopa
- Kupweteka kwa m'mimba kwambiri
Maphunziro oyambirira a ziweto za Tymlos anasonyeza kuwonjezeka kwa mtundu wa khansa ya mafupa yotchedwa osteosarcoma mu makoswe a labu. Motero, Tymlos amabwera ndi chenjezo lakuda. Kuwonjezeka kumeneku kunapezeka kuti kudalira kuchuluka kwa mankhwala omwe amapezeka ndi makoswe. Ngakhale sizikudziwika ngati chiopsezochi chilipo mwa anthu, Tymlos amagwiritsidwa ntchito pochizira matenda odwala matenda a m'mimba kwa zaka zoposa ziwiri.
Mawu Ochokera
Kawirikawiri, matenda a mitsempha ndi matenda omwe amayamba pa moyo wanu wonse. Izi zimakupatsani mwayi wambiri wosintha moyo wanu kapena kuyesa mankhwala kuti muteteze. Koma ngati mwapezeka kuti muli ndi matenda a osteoporosis, simuyenera kunyalanyaza matenda. Lankhulani ndi dokotala wanu kuti mudziwe zomwe mungachite komanso mankhwala omwe alipo kuti akuthandizeni kukhala bwino ndi vutoli.
> Chitsime:
> Gonnelli, S., & Caffarelli, C. (2016). Abaloparatide. Matenda a Kachipatala mu Metabolism Zamchere ndi Zamtundu , 13 (2), 106-109. http://doi.org/10.11138/ccmbm/2016.13.2.106