Kodi PARP inhibitors ingathandize bwanji pa khansa ya m'mawere? Mankhwala angapo otchedwa PARP inhibitors apangidwa posachedwapa pofuna kuchiza khansa ya m'mawere. Kodi mankhwalawa ndi otani, ndipo angakhale nawo otani pakuyang'anira anthu omwe ali ndi kansa ya m'mawere?
About PARP and DNA Repair
PARP ndichidule cha polymerase ya poly (ADP-ribose).
PARP ndi mapuloteni omwe ali ndi maudindo angapo m'maselo, makamaka mwa DNA kukonza ndi pulojekiti imfa (apoptosis). Maselo a thanzi angagwiritse ntchito PARP kukonza okha ndikukhala moyo wawo wabwino. Koma maselo a khansa angagwiritsenso ntchito PARP kukonzanso kuwonongeka kwa DNA, motero kukulitsa kukula kwawo kosalamulirika. Mankhwalawa akhoza kukhala osagwira ntchito. Pali mapuloteni osiyanasiyana a PARP, ndipo aliyense ali ndi udindo wake pazochitika m'maselo.
PARP Inhibitors ndi Chithandizo cha khansa ya m'mawere
PARP inhibitor ndi mankhwala omwe amaletsa mapuloteni a PARP pakuchita ntchito zawo pokonzanso maselo a khansa yowonongeka. Chemotherapy ndi ma radiation pogwiritsa ntchito DNA ya maselo kuti asabereke. Mitundu ina ya maselo a kansa amagwiritsa ntchito michere ya PARP kuti ikonzekerere DNA yawo ndi kubwezeretsedwa ku chiopsezo cha khansa. Mayesero angapo akuchipatala akuchitidwa kuti awone ngati PARP inhibitors, kuphatikizapo mankhwala ena a khansa, akhoza kuletsa mapuloteni a PARP ku maselo a khansa yowonongeka.
Zotsatira pa Maselo a Khansa ya M'bwere
Ngati PARP inhibitor ikuwonjezeredwa kuchipatala cha m'mawere, akatswiri amayembekezera kuti maselo a khansa omwe amatsutsa mankhwala osokoneza bongo amatha kuwonongeka chifukwa cha kuwonongeka kwa DNA. Nthawi zina, PARP inhibitor ingagwiritsidwe ntchito yokha , m'malo mogwirizanitsa ndi chemo ndi ma radiation.
Ngakhale nkhani yabwino ndi yakuti PARP inhibitors sizimawoneka kuti imakhudza maselo abwino, osakhala ndi khansa. Izi zikutanthauza kuti zochepa zimakhala zovuta kwa odwala komanso mofulumizitsa kuchipatala kuchokera kuchipatala.
Chiyembekezo cha Odwala Matenda Achiwerewere
PARP inhibitors angakhale othandiza makamaka kwa odwala omwe ali ndi khansa ya m'mawere. Anthu omwe ali ndi BRCA1 ndi BRCA2 kusintha kwa chibadwa chawo ali pachiopsezo chachikulu chokhalira ndi khansa ya m'mawere. Zamoyo zabwino za BRCA zimapanga mapuloteni omwe amatha kuponderetsa mapangidwe a ziwalo ( amatchedwa tumor suppressor genes ), koma majeremusi a BRCA alibe mutha kupanga mapuloteni ameneĊµa olimbana ndi maselo a kansa. PARP inhibitors angagwiritse ntchito zofooka zomwe zili ndi khansa ndi BRCA yosinthika. Njira imodzi yomwe mungagwiritsire ntchito PARP inhibitors ikhoza kukhala yothandiza kupewa khansa ya m'mawere . Mwina PARP inhibitors idzakhala njira yothandizira amayi omwe ali ndi chiopsezo chachikulu ndipo zikhoza kuthetsa vutoli.
Kulimbikitsa Nkhani Za Khansa Zachiwerewere Zitatu Zosasamala
Mayesero angapo a chipatala cha PARP inhibitors apeza kuti ena amapindula mwa kuwonjezera PARP inhibitor kuchipatala china cha khansa ya khansa ya katatu yosalala . Mu maphunziro awa, PARP inhibitors anali olekerera bwino. Panthawiyi, mankhwala okhaokha omwe amavomerezedwa ndi khansa ya m'mawere ndi bevacizumab, koma mankhwalawa alibe phindu lapadera kwa anthu omwe ali ndi khansa ya m'mawere itatu.
Ntchito zina za PARP Inhibitors
Mankhwala opangidwa ndi PARP inhibitors akuyesedwa pa mitundu ingapo ya khansa: mawere ndi mazira, uterine, ubongo, ndi pancreatic. Mu 2015, PARP inhibitor inavomerezedwa kuti ayambe kulandira khansa ina ya mazira.
Kufunika Kwambiri kwa PEP Inhibitors
Kuwonjezera kwa PARP inhibitors ku zida zankhondo zotsutsana ndi khansa ya m'mawere zikuwoneka bwino kwambiri. PARP inhibitors imapangitsa kuti mankhwala a chemotherapy apindule kwambiri ndi khansa yachiwawa komanso yachitatu ya khansa, mwina popanda kuwonjezera zotsatira zoyipa zambiri. Mankhwalawa amawonekera kuti apangitse umoyo wabwino komanso kupititsa patsogolo odwala.
Kulimbana ndi khansa ya m'mawere pamlingo wa DNA yake ikuwoneka ngati mtsogolo.
> Zotsatira:
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