Ngati mukukhala ndi kunyezimira kotentha , mukudziwa kuti kutengeka sikusangalatsa monga momwe mwakhalira ndikuwonetsera. Mzimayi wina yemwe adafotokoza kuwala kotentha monga "kukhala nacho yekha chilimwe" ayenera kuti anayiwala za milu ya zovala yomwe ikupita ndi drenchings izi periodic. Komabe ife tikuphunzira kuti kutentha kotentha sikuli koipa nthawi zonse. Ndipotu, iwo akhoza kukhala ovala zasiliva, akulosera kuti khansa yanu ya m'mawere ikugwira ntchito kapena kuti muli pangozi yochepa kusiyana ngati simunayambe kutentha ndi mankhwalawa.
Zofufuza zimatiuza kuti "zovuta" zomwe zimatentha kwambiri-makamaka ngati zimakhala zoopsa ndipo zimachitika nthawi zambiri kuti zitha kupulumuka kwa anthu omwe amachiritsidwa ndi mankhwala opatsirana pogwiritsa ntchito khansa ya m'mawere monga tamoxifen kapena aromatase inhibitor exemestane. Ndipo kwa iwo omwe sanaonepo khansa ya m'mawere koma akulimbana ndi kutentha, nthawi izi zimagwedeza (kapena kuthira) zingakhale chizindikiro chabwino.
Tiyeni tiwone zomwe tikuphunzira zokhudza kutentha kwa moto ndi zochitika zina zovuta zokhudzana ndi chithandizo cha khansa ya m'mawere, ndi momwe mungagwiritsire ntchito chidziwitso ichi m'njira yomwe ingakuthandizeni kuthana ndi zotsatirazi zowopsya.
Estrogen, Kutentha Kwambiri, ndi Khansa Yamtundu
Mwanjira, n'zomveka kuti mazira otentha angagwirizane ndi chiopsezo chachikulu cha khansa ya m'mawere kapena kubwereza khansa ya m'mawere. Timadziŵa bwino kuti estrogen imathandiza kwambiri mu khansa ya m'mawere ndi kutentha kwambiri nthawi zambiri pamene mazira amasiya kupanga estrojeni panthawi yopuma.
Ndi khansa ya m'mawere, estrogen imakhala ngati mafuta a jet, mofulumira kukula kwa khansa ya m'mawere yotchedwa estrogen . Pamene estrogen imatsekedwa (kapena ngati androgens atatha kusamba saloledwa kutembenuzidwa ku estrogen), maselo a kansa ya m'mawere amatha kutuluka mwa mafuta.
Mankhwala a mahomoni omwe amagwiritsidwa ntchito pa khansa ya m'mawere amachititsa kuti kutentha kumatentha, koma kutentha kotentha sikuli kofanana kwa munthu aliyense.
Anthu ena amadandaula kwambiri chifukwa cha kutentha kwa nthawi zambiri komanso kutuluka kwa usiku, pamene ena amawona "pang'ono" kapena "palibe." Podziwa izi, n'zomveka kuti ochita kafukufuku angafune kudziwa ngati amayi omwe amawotcha kwambiri (omwe amatchulidwa ndi madokotala kuti ndi " zizindikiro zakufa ") amayankha bwino mankhwalawa.
Kutentha Kwambiri, Kuchiza Khansa ya M'thupi, ndi Kupulumuka
Maphunziro angapo pakati pa 2012 ndi 2016 adayang'ana ngati kutentha kotentha kungakhale chizindikiro chakuti wina angayankhe bwino mankhwala enaake, komanso ngati amayi omwe ali ndi kutentha kwakukulu amatha kuyamba khansa ya m'mawere.
Ngakhale tikudziwa kuti kutentha kwa moto kumagwirizana ndi kuchepa kwa estrogen m'thupi, sitikudziwa momwe zimakhalira kapena chifukwa chake. Mwa kuyankhula kwina, sitikudziwa ngati mazenera otsika a estrogen amathandiza kuzimitsa kutentha komanso kukula kwa khansa ya m'mawere, kapena ngati pali njira zina zomwe zimayendera njira ziwirizo.
Matenda a Hormone Opatsirana ndi Estrojeni Opatsa Khansa Yabwino Yamatenda
Tisanayambe kunena za kufunika kwa kutentha kwa khansa ya m'mawere, ndizothandiza kutchula mankhwala omwe timayankhula, omwe amachitidwa ngati mankhwala oopsa a khansa ya m'mawere.
Mwachidule, pali mitundu iwiri yoyamba ya mankhwala a mahomoni omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere yotchedwa estrogen.
- Kusankha estrogen receptor modulator (SERMs) monga tamoxifen -Tamoxifen amagwira ntchito poletsa kuteteza isrogen kukhala ndi maselo a kansa ya m'mawere ndikuwathandiza kukula. Azimayi omwe ali ndi matendawa amayamba kupanga estrogen ndipo mankhwala ngati tamoxifen amafunika.
- Aromatase inhibitors (AIs) - AI ndi mankhwala omwe amagwiritsidwa ntchito m'mayi am'mawopeni (kapena amayi omwe ali ndi amayi omwe amachiritsidwa ndi mankhwala ochotsera ovari kapena omwe amachotsa mazira awo) kuti asatengere maantirogen m'thupi. Amachita zimenezi mwa kuletsa kutembenuka kwa androgens kwa estrogen, zomwe zimayambitsidwa ndi mavitamini otchedwa aromatases. Mankhwala osokoneza bongo omwe amagwiritsidwa ntchito ngati aromatase, amachititsa kuti aziphatikizapo Arimidex (anastrozole), Aromasin (exemestane) ndi Femara (letrozole).
Kutentha, Kutentha Kwambiri, ndi Kuteteza kwa Khansa Yamatenda
Kafukufuku amene adachitika mu 2012 akuyang'ana akazi omwe akudwala mthempha ya mthendayi adapeza kuti iwo omwe anali kutentha kwambiri pakapita kuchipatala anawonjezereka kwambiri. Kuphunzira kwina mu 2016 kuyang'anitsitsa amayi omwe ali ndi vuto lopatsidwa chithandizo ndi exemestane analandira zotsatira zofanana. Azimayi omwe anali ndi zotsatira zotha kupweteka kwambiri (kutentha ndi kutuluka kwa usiku) amatha kuchitapo kanthu pochita chithandizo cha mpweya kuposa awo omwe analibe zizindikiro (70 peresenti ndi 40 peresenti.) Mosiyana, panalibe kusiyana pakati pa mlingo woyankha mankhwala pakati pa iwo omwe anali kapena analibe minofu ya minofu kapena ululu wamodzi. Mu phunziro ili, yankho la chiwombankhanga likufotokozedwa ngati 30 peresenti kapena kuchepa kwakukulu pa kukula kwa chifuwa pa maphunziro a kujambula.
Tamoxifen (kapena Exemestane), Kutentha Kwambiri, ndi Kupulumuka kwa Khansa ya M'bwere
Kuphunzira kwa 2013 kunayang'ana akazi opitirira 9,000 amene anachitidwa ndi tamoxifen kapena mpikisano. Anthu omwe anali ndi kutentha kwambiri anali ndi moyo wabwino kwambiri wopulumuka matenda (ndi 27 peresenti), moyo wonse (45 peresenti yapamwamba) ndi zochepa zochepa za metastases (19 peresenti yosachepera kuti khansa zawo za m'mawere zikhoza kufalikira ku ziwalo zakutali monga ubongo, mapapo, chiwindi , kapena mafupa.)
Mu phunziroli (mosiyana ndi phunziro ili pamwambapa), amayi omwe anali ndi minofu ndi ophatikizana, komanso omwe anali ndi zizindikiro zowonongeka anali opulumuka kusiyana ndi amayi omwe analibe zizindikiro izi.
Kuwotcha Kwambiri ndi Kuopsa kwa Kukula Khansa ya M'bwere
Ngakhale ziri zomveka mwanjira yomwe anthu omwe amawotcha sangathe kukhala ndi kansa ya m'mawere; Sipanakhale posachedwapa kuti maphunziro adapeza kuti izi ndi zoona.
Kafukufuku wa 2011 anapeza kuti akazi omwe anali ndi kutentha kwambiri anali pafupi theka lakale kwambiri kuti akhalitse khansa ya m'mawere kusiyana ndi akazi omwe sankawotche. Azimayi omwe anali ndi kutentha kwambiri anali 50 peresenti yocheperapo kuti azikhala ndi khansa yotentha ya m'mawere ndipo 50 peresenti yochepetseka yochepetsetsa lobular carcinoma ya m'mawere . Kuwonjezera apo, anapeza kuti nthawi zambiri kutentha kunkachitika, ndipo mozama kwambiri, anali kuchepetsa kwambiri chiopsezo cha khansa ya m'mawere.
Phunziro lina loyamba mu 2013 linapeza kuti amayi omwe adakumana ndi mazira otentha (ndi zizindikiro zina za mimba) anali ndi hafu yokha yopanga khansa ya m'mawere yoyamba yomwe imatchedwa kuti khansa ya m'mawere isanafike zaka 50) kuposa amayi omwe sanadziwepo izi zizindikiro.
The Link Between Hot Flashes ndi Khansa ya M'bwere
Ngakhale kuti maphunziro onsewa apeza kugwirizana pakati pa kutentha kwa moto ndi njira yabwino yothandizira mankhwala opatsirana khansa ya m'mawere (kapena chiopsezo chochepa cha khansa ya m'mawere) sitidziwa bwinobwino momwe izi zilili zogwirizana kapena momwe izi zimachitikira.
Thandizo la Mafuta Otentha
Kuwotcha kwa moto sikusangalatsa ndipo samapanga zambiri kuti apititse patsogolo umoyo wa amayi ambiri omwe ali ndi khansa ya m'mawere. Mwamwayi, kafufuzidwe ikuyang'ana njira zowonjezera zizindikiro izi (pamene ndikupewa estrogen.)
Chenjezo ndilo kuti iwo amene akulingalira njira zochiritsira zosagwiritsidwa ntchito monga mankhwala a zitsamba kuti athe kulimbana ndi zotentha. Zina zowonjezerapo monga soya zili ndi " phytoestrogens ," isrogens yopanga zomera ndi malo otchedwa estrogen. Popeza estrogen imagwiritsidwa ntchito ngati mafuta a khansa ya m'mawere kwa anthu omwe ali ndi zotupa zotchedwa estrogen, asayansi ambiri amalimbikitsa kuti asawonongeke mowonjezereka mpaka tidziwa zambiri.
Effexor ndi matenda othetsera nzeru omwe angathandize ndi kutentha kwa akazi ena, ndipo mosiyana ndi ena a anti-depressants, samaoneka kuti ali ndi mgwirizano womwewo ndi tamoxifen. Neurontin (gabapentin) ndi mankhwala okhwima omwe angathandize kuchepetsa kutentha. Amagwiritsidwanso ntchito pochiza matenda a ubongo ndi kupweteka kwa ubongo zomwe anthu ena amapanga pa mankhwala a kansa ya m'mawere.
Ngakhale kuti vitamini E yakhala ndi ena, mtundu wa vitamini E ndi wofunikira kwambiri, monga mitundu ina ya vitamini E ingathetsere zotsatira za chemotherapy. Mosiyana, mawonekedwe amodzi omwe amatchulidwa kuti tocotrienols angathe kukhala ndi zotsatira za tamoxifen pa maselo a khansa ya m'mawere a estrogen.
Musanayambe kuwonjezera chowonjezera, onetsetsani kuti mungalankhule ndi dokotala wanu. Tikudziwa kuti pali mavitamini ndi amchere omwe angakonzekere mankhwala ochepetsa khansa .
Anthu ena apeza kuti mankhwalawa amathandiza ndi kutentha, koma kachiwiri, kambiranani ndi dokotala wanu. Zina mwa njira zabwino zothetsera kutentha ndizosavuta. Onetsetsani njira 10 zomwe mungathe kupirira ndi kutentha kwa khansa ya m'mawere .
Mawu Ochokera
Chofunika kwambiri pa maphunziro omwe akuyang'ana pa kutentha kwa khansa pamatenda a khansa ya m'mawere (mankhwala osakaniza ndi mankhwala a mahomoni) ndikuti zotentha zotentha zimakhala ndi siliva. Kudziwa izi sikungapangitse kuti kutentha kwanu kukhale kovuta, koma izi zikhoza kukhala njira yogwiritsira ntchito reframing kukuthandizani kupirira.
Reframing ndi ndondomeko yomwe mumayang'anitsitsa mkhalidwe wosiyana. Mwachitsanzo, mmalo moganizira za kutaya tsitsi lanu pa mankhwala a chemotherapy komanso momwe zimakuchititsani kumva, mungathe kupeza ndalama zasiliva-simusowa kumeta miyendo kwa miyezi yambiri. Zoonadi, izo zikutambasula pang'ono, koma nthawi yotsatira mukakhala ndi kutentha kwambiri mungathe kufotokozera kutentha kwachangu kuthamangitsa maselo ena a khansa ya m'mawere omwe angakhalebe m'thupi lanu. Mwanjira imeneyo, osachepera "chilimwe chanu" chili ndi siliva.
> Zotsatira:
> Desai, K., Mao, J., Su, I., Demichele, A., Li, Z., Xie, S., ndi P. Gehrman. Zowopsa ndi Zowopsya Chifukwa cha Kusagwirizana Pakati pa Khansa ya M'bwere Odwala pa Aromatase Inhibitors. Thandizo Lothandiza ku Khansa . 2013. 21 (1): 43-51.
> Fei, C., DeRoo, L., Sandler, D., ndi C. Weinberg. Zizindikiro za Manopausal ndi Kuopsa kwa Khansa Yoyamwitsa Yoyamba. European Journal ya Cancer . 2013. 49 (4): 798-804.
> Fontein, D., Charehbili, A., Nortier, J. et al. Zochitika Zowonongeka Zenizeni Zimayanjanitsidwa ndi Kuyankha kwa Exemastane Medical in Postmenopausal Cancer Patients: Zotsatira kuchokera ku TEAMIA Study (BOOG2006-04). European Journal of Oncology Opaleshoni . 2016 Dec 10.
> Fontein, D., Houtsma, D., Hille, E. et al. Kugwirizana Pakati pa Zochitika Zoipa Zoipa ndi Zogwira Mtima za Opaleshoni ya Exemastane M'matenda Oyamba a Amuna Omwe Amatha Kudwala Khansa ya Amuna Akumbuyo. Annals of Oncology . 2012. 23 (12): 3091-7.
> Fontein, D., Seynaeve, C., Hadji, P. et al. Zochitika Zowonongeka Zenizeni Zimalongosola Kupulumuka Kwa Odwala Odwala Omwe Amagwiridwa ndi Tamoxifen kapena Aromatase Inhibitors: Kufufuza Kwachidule kwa International Tamoxifen Exemestane Adjuvant. Journal of Clinical Oncology . 2013. 31 (18): 2257-64.
> Huang, Y., Malone, K., Cushing-Haugen, K., Daling, J., ndi C. Li. Chiyanjano pakati pa Zizindikiro za Mwamuna ndi Mavuto a Khansa ya M'thupi Yam'mawere. Khansa Epidemiology Zida ndi Kupewa . 2011. 20 (2): 379-88.