HER2 , yomwe imatchedwanso HER2 / neu ndi HER-2, ndichidule cha mtundu wa epidermal kukula factor receptor 2. Kudziwa malo anu HER2 ndi gawo lofunika kwambiri lanu.
HER2 ndi jini yomwe imayimira mapuloteni omwe alipo pamwamba pa maselo. Selo labwino la m'mawere lili ndi makope awiri a HER2 gene. Pafupifupi 30 peresenti ya khansa ya m'mawere, maselo a khansa ya m'mawere ali ndi makope oposa awiri a jini, ndipo izi zimayambitsa kupanga puloteni ya HER2.
Zotsatira zake, maselo okhudzidwa amakula ndikugawana mofulumira kwambiri.
Kufotokozera zambiri kapena kupititsa patsogolo kachilombo ka HER2 kunasonyezedwa kuti kumathandiza kwambiri pakukula ndi kupita patsogolo kwa mitundu ina ya khansa ya m'mawere ndi mitundu ina ya khansa.
Kodi Ndicho Cholowa?
Vuto lachibadwali silinatengedwe kuchokera kwa makolo anu. Zosavuta za jini izi zimagwirizana ndi ndondomeko ya khansa.
Zotsatira Zabwino ndi Zowononga Zotsatira
Ngati khansa yako ya m'mawere imayesedwa pa HER2, zotsatirazo zidzasinthidwa ngati zabwino kapena zoipa. Ngati zotsatira zanu zikulumikizidwa ngati HER2 zabwino, zikutanthauza kuti majeremusi anu a H2 ali operewera kwambiri popanga mapuloteni a HER2. Ngati zotsatira zanu zili ndi HER2 zosalongosoka, ndiye kuti majeremusi a HER2 sakukulitsidwa.
Zochiritsidwa Zilipo
Herceptin (trastuzumab) ndi mankhwala omwe akugwiritsidwa ntchito pochiza khansa yabwino ya HER2. Ndi mankhwala othandizidwa ndipo amatchedwanso kuti chitetezo cha mthupi.
Mankhwala awa adzaperekedwa mwachangu, kamodzi pa masabata awiri kapena atatu. Ukadakhala m'dongosolo lanu, Herceptin amawopera mapuloteni a HER2 omwe ali ochulukirapo pamwamba pa maselo a khansa ya m'mawere. Izi zimathandiza kuletsa kukula kwa maselo a kansa abwino a HER2.
Zotsatira zina za mankhwala a Herceptin ndi awa:
- amachepetsa HER2 zabwino zotupa, asanachitidwe opaleshoni
- amachotsa maselo a khansa abwino a HER2 omwe afalikira kupyola chilakolako choyambirira.
- Amathandizira kupewa kubwereza (kubwerera) kwa khansa yabwino ya HER2
Mayesero a HER2
Dokotala wanu angapemphe mayeso angapo:
- NTHAWI: Fluorescence In Situation Hybridization -chiyesochi chimagwiritsa ntchito mapuloteni a fulorosenti kuti ayang'ane chiwerengero cha makope a majeremusi a H22 mu selo lotupa. Ngati pali makope oposa awiri a HER2, ndiye kuti khansara ndi HER2 zabwino.
- IHC: ImmunoHistoChemistry -yesoyi ikuyesa kupanga puloteni ya HER2 ndi chotupacho. Zotsatira za mayesero ndizoyikidwa monga 0, 1+, 2+, kapena 3+. Ngati zotsatira ziri 3+, khansara yanu ndi HER2-positive. Ngati zotsatirazo ziri 2+, mudzafunika mayeso a FISH kudziwa ngati khansara ndi HER2-positive.
Mfundo Yofunika Kwambiri
HER2 khansa yabwino ya m'mawere imapezeka ndi HC kapena FISH test test. Zotsatira za HER 2 zabwino ndizofunikira, monga zikuwonetsa kuti khansara ikhoza kuchiritsidwa ndi Herceptin, komanso Perjeta ndi Kadcyla. Ngati kansa yanu imapezeka ngati HER2 zabwino, zimakhala zowawa kwambiri. Kutenga chithandizo mwamsanga kungathandize kusintha moyo wanu, komanso kuthandizira kupewa kubwereza.