Monga momwe sayansi ya zamankhwala imamvetsetsa zambiri za matenda a fibromyalgia (FMS), makampani a mankhwala akuyesa kuti FDA ivomereze mankhwala ambiri a fibromyalgia. Madokotala amapereka mankhwala omwe amavomerezedwa ndi mankhwala ambirimbiri omwe alibe mankhwalawa chifukwa awapeza kuti akuwathandiza.
FDA-ANASANKHA MAFUTA A FIBROMYALGIA
Lyrica (pregabalin) : Mu June 2007, Lyrica anakhala mankhwala oyamba a FDA-approved a fibromyalgia.
M'mayesero am'chipatala , anthu omwe ali ndi FMS adasintha kwambiri kupweteka, kugona, kutopa, ndi khalidwe la moyo . Yopangidwa ndi Pfizer, Lyrica nayenso amavomerezedwa kuti athetse ululu wa matenda a shuga ndi neuralgia . Amagwiritsidwanso ntchito, kuphatikiza ndi mankhwala ena, kuti asatengeke pang'ono pang'onopang'ono kwa odwala akhunyu.
Zingamveke zosamvetseka, koma Pfizer sakudziwa bwino chifukwa chake Lyrica amagwira ntchito. Izi ndi zomwe zikunena pa webusaiti ya FDA:
Mchitidwe wa ntchito siudziwika, koma pali deta yomwe imasonyeza kuti zimakhudza kutulutsidwa kwa opaleshoni ya ubongo mu ubongo. Mapulogalamu a m'mimba ndi mankhwala m'maganizo omwe amatulutsa chizindikiro kuchokera ku neuroni kupita ku chimzake.
Cymbalta (duloxetine) : The FDA approved Cymbalta mankhwala fibromyalgia mu June 2008. Cymbalta amadziwika monga SNRI, kapena serotonin-norepinephrine kubwezeretsa inhibitor. Serotonin ndi norepinephrine ndizozidzidzimadzi zomwe zimakhala ndi anthu omwe ali ndi fibromyalgia.
SNRI amapanga zina zambiri zomwe zimapezeka ku ubongo.
Cymbalta kale idali ndi FDA-yovomerezedwa kuti athetse kuvutika maganizo ndi matenda a shuga .
Savella (milnacipran) : Mankhwala osokoneza bongo ku msika wa US, Savella adavomerezedwa mu Januwale 2009 ngati mankhwala osokoneza bongo. Wopangidwa ndi Forest Laboratories, Inc. ndi Cypress Bioscience, Inc., Savella ndi wodetsa nkhaŵa wofanana ndi Cymbalta kupatula kuti ndi mankhwala oyamba m'kalasi kuti apititse norepinephrine kuposa Serotonin.
Ntchito Yatsopano ya Drug , yomwe idatumizidwa mu December 2007, idaphatikizapo deta kuchokera ku mayesero awiri a Gawo III omwe akuphatikiza odwala oposa 2,000. Kampaniyo inati deta inasonyeza Savella inali yothandiza kwambiri kuposa placebo ndipo inalekerera bwino. Panalibe imfa ndipo zotsatira zake zambiri zidalinso zofatsa.
Milnacipran imagulitsidwa ku Ulaya pansi pa mayina a Dalcipran ndi Ixel. Yakhala pa msika kwa zaka khumi ndipo amavomerezedwa kuvutika maganizo m'mayiko oposa 50.
KUFUNA KUYANKHA NJIRA ZA FIBROMYALGIA
JZP-6 (sodium oxbate) : Mavuto a chipatala a JZP-6 (chogwiritsira ntchito ku Xyrem) chinasonyeza kuti zimakhala bwino kwambiri kugona tulo komanso kuchepa kwa odwala fibromyalgia . JZP-6 ndi dongosolo lalikulu la mitsempha lopweteka ndipo limalingalira kuthandiza wodwala kufika pa siteji yowonjezera 3 ndi masitepe 4 ogona. Chigamulo cha matenda a Phase III chomwe chinapangidwa mu Sept. 2008 ndi Jazz Pharmaceuticals chinapereka New Application drug to FDA mu December 2009. Zotsatira za mayesero ena a Phase III akuyembekezereka, koma kampaniyo inapeza kuti zotsatilazi zathandizidwa kale.
Xyrem ndi FDA-yovomerezeka kuti ikhale yopweteka (kutaya mwadzidzidzi kwa kupsinjika kwa minofu) ndi kugona kwa tsiku ndi tsiku kwa odwala omwe ali ndi vutoli.
Zindikirani: Chifukwa cha kuchitidwa nkhanza, Xyrem ndi katundu wa dongosolo la III.
Adeona Pharmaceuticals akuyembekezera kuti Effirma adzivomerezedwe ku United States kwa nthawi yoyamba, ndipo mu April 2008 kampaniyo inalengeza kuti US FDA inapereka ntchito yofufuza ya New Drug Application. Izi zimapatsa kampani chilolezo choyesa mayesero achimake omwe amachititsa kuti Pulezidenti Wachiwiri Wachiwiri Wachiwiri wa Edzi apitirize kuchita kwa Effirma monga chithandizo cha FMS.
Mankhwalawa amavomereza ku Ulaya kwa zaka zoposa 25. Kumeneku, amagwiritsidwa ntchito pochiza ululu kuchokera ku magulu osiyanasiyana, kuphatikizapo opaleshoni , khansa, matenda ndi chiwindi.
Adeona, akuyembekeza kusonyeza kuti amachitira zambiri osati kupweteka kwa FMS, koma amachititsa kuti azikhala osangalala, atenge, mavuto ozindikira, kugona tulo komanso ntchito zonse.
ZINTHU ZINA ZA FIBROMYALGIA
Kudetsa nkhawa: Antidepresants amachititsa kuti mitundu yambiri ya ubongo mu ubongo, kuphatikizapo neurotransmitter serotonin komanso mahomoni opwetekedwa norepinephrine - onse ali otsika kwambiri kwa anthu omwe ali ndi nkhawa kapena FMS.
- Dual Reuptake Inhibitors: Kalasiyi ikuphatikizapo Cymbalta ndi Savella. Zitsanzo zina za mankhwalawa ndi: venlafaxine ndi nefazodone.
- Matenda a Tricyclic Oponderezedwa : Ngati atengedwa usiku, mankhwalawa angathandize anthu omwe ali ndi FMS kupeza ubwino wokhala ndi ubwino. Amaonjezeranso zotsatira za endorphins yopha kupweteka komanso kuthandiza kupumula kwa minofu . Matenda ena omwe amagwiritsidwa ntchito pochiza FMS ndi awa: amitriptyline, doxepin ndi nortriptyline.
- Mankhwala a Serotonin Reuptake Inhibitors ( SSRI s): Mankhwalawa amachititsa kuti ubongo kumasulire serotonin yambiri, yomwe imathandiza kuchepetsa kugona, ndipo nthawi zina amathandiza anthu omwe ali ndi FMS kuti asamakhale otopa ndikupeza mpumulo ku zizindikiro zina. Komabe, amatha kusokoneza tulo. Zitsanzo za SSRIs ndi: fluoxetine, paroxetine ndi sertraline.
Mankhwala onse omwe atchulidwa pano ali ndi zotsatira zoyipa ndipo angayambitse vuto lalikulu la mankhwala ngati mutasiya kuwatenga mwadzidzidzi. Ndikofunika kuti muzilankhulana ndi dokotala kuti mukambirane mavuto alionse kapena kusintha kwa mlingo.
OPIATES / NARCOTICS AS FIBROMYALGIA ZOTHANDIZA
Kafukufuku amasonyeza kuti opiates sagwirizana ndi ululu wa FMS. Komabe, anthu ambiri amanena kuti akuthandiza, ndipo mankhwalawa nthawi zambiri amaperekedwa kwa iwo.
Opiates / mankhwala osokoneza bongo ndi awa:
- Vicodin (hydrocodone acetaminophen)
- Percocet (oxycodone acetaminophen)
- OxyContin (oxycodone)
Pofuna kuthetsa mantha a kuchitiridwa nkhanza ndi oledzera, American Pain Society yatulutsa malangizo kwa madokotala.
ZOKHUDZA NKHONDO & SAFETY RESOURCES
- Onetsetsani kuti dokotala amadziwa za mankhwala onse ndi zakudya zowonjezera zomwe mukuzitenga. Lankhulani ndi dokotala wanu kapena wamankhwala zokhudzana ndi zotsatira zake ndipo zingakhale zovuta kuti muthane.
- Kuti muwone mndandanda wa zotsatira zolakwika ndi kuyanjana kwa mankhwala , pamodzi ndi zambiri zambiri, onani Drugs.com kapena RxList.com.
- Ngati muli ndi zotsatira zovuta kwa mankhwala, onetsetsani kuti mwawawuza kudzera mu FDA Safety Information and Adverse Event Reporting Program.
Chitsime:
NIH Publication NO. 04-5326.
US Food and Drug Administration. "Kukhala ndi Fibromyalgia"