FDA-Yavomerezedwa Kuyambira 2009
Savella (milnacipran) anali a FDA -vomerezedwa mu January 2009 monga mankhwala fibromyalgia . Pa nthawi imeneyo, inali mankhwala atsopano kumsika wa US. Chifukwa ndi zatsopano, palibe mawonekedwe achibadwa omwe alipo.
Savella ndi serotonin-norepinephrine reuptake inhibitor, kapena SNRI. Mwakutanthauzira, SNRIs ndi othetsera nzeru. Komabe, Savella sakuvomerezedwa kuvutika maganizo ku US Pakalipano, fibromyalgia ndizovomerezeka kugwiritsidwa ntchito mmayikowa.
Komabe, milnacipran imagulitsidwa ku Ulaya pansi pa mayina osiyanasiyana, kuphatikizapo Dalcipran, Ixel, ndi ena. Mankhwala a Milnacipran akhala akupezeka m'misika kunja kwa zaka zoposa khumi ndipo amavomereza kuti akuvutika maganizo m'mayiko oposa 50.
Zimene Savella amachita
Savella imachulukitsa mphamvu za serotonin ndi norepinephrine , zomwe zingakhale zochepa kwa anthu okhala ndi fibromyalgia. Izi zimaika m'kalasi yomweyi monga Cymbalta , yomwe ndi FDA-yovomerezeka ku fibromyalgia, kupweteka kwaukali, kupsinjika maganizo, ndi zinthu zina zochepa.
Savella, komabe, ndizolembedwa kuti ziwonjezere norepinephrine kuposa Serotonin.
Ntchito Yatsopano ya Drug ya Savella, yomwe idatumizidwa mu December wa 2007, inafotokoza deta kuchokera ku mayesero awiri a Phase III okhudzana ndi odwala oposa 2,000. Kampaniyo inati deta inasonyeza Savella inali yothandiza kwambiri kuposa placebo ndipo inalekerera bwino. Panalibe imfa pakati pa maphunzirowo ndipo zotsatira zake zambiri zidalinso zofatsa.
Maphunziro amtsogolo athandiza zotsatira zoyambirira, kusonyeza kusintha kwakukulu kwa zizindikiro, kuphatikizapo ululu, kutopa, ndi kugona. Komabe, ndemanga ya 2015 inatsimikizira kuti izi ndi zothandiza kwa pafupifupi 40 peresenti ya iwo omwe amatenga izo. (Zomwezo ndi zofanana ndi za Cymbalta komanso mankhwala ena a FDA omwe amavomerezedwa ndi fibromyalgia, Lyrica .)
Savella Mlingo
Mlingo woyenera wa Savella ndi 100 mg kapena 200 mg pa tsiku, kugawidwa muwiri. Ndizoyambira kuti muyambe pa mlingo waung'ono ndipo pang'onopang'ono mugwiritse ntchito ndalama zonse.
Sizitetezeka kusiya mwachangu kutenga Savella. Ngati mukufuna kuchoka ku mankhwalawa, onetsetsani kuti mukuyankhula ndi dokotala wanu za njira yoyenera yoyeretsera .
Savella Side Effects
Monga mankhwala onse, Savella angayambitse zotsatira zina zoipa. Sikuti aliyense amawapeza, koma muyenera kudziwa zomwe ali nazo mutayamba kumwa mankhwalawa. Zina mwa zotsatira zake zingakhale zovuta.
Pezani thandizo lachipatala nthawi yomweyo ngati muli ndi zizindikiro zotsatirazi:
- kuopsa kwa kupweteka, kupweteka kupuma, kukanika pachifuwa, kutupa kwa nkhope, milomo kapena lilime)
- khalidwe lodabwitsa
- zamagazi zamagazi kapena zakuda
- chisokonezo
- mitsempha yamdima
- thukuta kwambiri
- kutaya
- kufulumira kapena kusagwirizana kwa mtima
- malungo
- zovuta
- kupweteka kosalekeza
- malingaliro
- kusamalidwa
- mavuto a kukumbukira
- kupweteka kwa minofu kapena kufooka
- kukhumudwa kwatsopano kapena kuwonjezereka, nkhawa, kukhumudwa, mantha, mantha, kupsa mtima, kukwiya, kupsa mtima, kapena kusakhoza kukhala chete
- malo otayika
- zofiira, zotupa, kunyezimira kapena kupukuta khungu
- kugwidwa
- kupweteka kwa mutu kapena chizungulire
- kunyoza kwakukulu kapena kosalekeza
- kusanza kapena kutsekula m'mimba
- vuto lalikulu kapena lolimbikira kugona
- ululu wamimba
- kudzipha kapena malingaliro
- kunjenjemera
- zovuta kukodza
- kupweteka kapena kupuma kwachilendo
- zovuta zachilendo kapena zovuta kusintha
- zofooka zachilendo
- khungu la maso kapena maso (jaundice)
Zotsatira zomwe sizikusowa kuchipatala ndi izi:
- kudzimbidwa
- kuchepetsa chilakolako chogonana kapena ntchito
- chizungulire
- Mlomo wouma
- mutu
- zothamanga
- thukuta lalikulu
- kusowa kwa njala
- kunyoza
- vuto logona
N'zotheka kuti mankhwalawa azitha kuyanjana wina ndi mzake. Lankhulani ndi dokotala wanu / kapena wamankhwala za matenda anu onse ndi kuthekera koyanjana ndi mankhwala ena omwe mungakhale mukuwatenga.
Kodi Savella Ndi Woyenera Kwa Inu?
Sitikudziwa chomwe mankhwala kapena mankhwala omwe angatithandize kufikira titayesera. Ngati mukufuna kuyesa Savella, kambiranani ndi dokotala wanu za ubwino ndi zokhumudwitsa ndikupanga chisankho pamodzi.
Zotsatira:
Ahmed M, et al. Journal za mankhwala ogona ogona. 2015 Sep 14. pii: jc-00381-14. Zotsatira za milnacipran pa vuto la kugona mu fibromyalgia: kuphunzira kosavuta, kawiri kawiri, kosaoneka bwino, komwe kumakhala kozungulira.
Cording M, et al. Msonkhano wa Cochrane wa ndemanga zowonongeka. 2015 Oct 20; 10: CD008244. Milnacipran chifukwa cha ululu wa fibromyalgia mwa akuluakulu.
Mease PJ, Palmer RH, Wang Y. Journal of clinical rheumatology. 2014 Jun, 20 (4): 195-202. Zotsatira za milnacipran pazochitika zambiri za kutopa ndi ubale wa kutopa kupweteka ndi ntchito: kufufuza kofufuzidwa kwa mayesero atatu a fibromyalgia.
Staud R, et al. Journal wa ululu. 2015 Aug; 16 (8): 750-9. Zotsatira za milnacipran pa ululu wa matenda ndi hyperalgesia ya odwala fibromyalgia: zotsatira za mayesero asanu ndi limodzi omwe amayesedwa mwachangu.
Vitton O, et al. Psychopharmacology yaumunthu. 2004 Oct; 19 Suppl 1: S27-35. Chiyeso chosagwiritsidwa ntchito chokhazikika pamtundu wa milnacipran pochiza matenda a fibromyalgia.