Mlomo wa Flupirtine: Wafa M'madzi?
Kodi Sipadzakhalanso M'paipi?
Mankhwala otchedwa oral flupirtine anali kusonyeza lonjezo monga mankhwala atsopano a fibromyalgia kumbuyo kwa 2008, pamene zikuwoneka kuti mankhwalawa ayamba kuyendetsa njira yopita ku FDA. Komabe, kuyambira apo, zikuwoneka kuti wagwa pa radar.
Oral flupirtine yakhala ikupezeka ku Ulaya kuyambira m'ma 1980. Kumeneku, amagwiritsidwa ntchito pochiza ululu kuchokera ku magulu osiyanasiyana, kuphatikizapo opaleshoni, khansa, matenda ndi chiwindi.
Ili ndi mbiri yakale ngati mankhwala oyenera komanso ogwira mtima.
US FDA inapatsa Adeona Pharmaceuticals ntchito yofufuza ya mankhwala atsopano kuti ayambe kuyesedwa pa fibromyalgia. Dzina lakuti Effirma linalembetsedwa kwa izo.
Adeona ali ndi Pipex Pharmaceuticals kuti agwire ntchito yolemba fomu ya FDA, koma webusaiti ya Pipex yakale yatha. Adeona potsiriza anasintha dzina lake kukhala Synthetic Biologics, ndipo Effirma sanatchulidwe kulikonse pa webusaiti ya Synthetic. Palibe chomwe chinaperekedwa ndi FDA, ndipo palibe maphunziro atsopano atulutsidwa.
Pakalipano, zikuwoneka ngati mankhwalawa akufa m'madzi ku US Izi ndizosautsa, chifukwa ndi zosiyana ndi mankhwala ena opatsirana pogwiritsa ntchito mankhwala a fibromyalgia m'njira zosangalatsa komanso zothandiza.
Momwe Mlomo Wa Mlomo Umagwirira Ntchito
Mankhwalawa ndi opiate / mankhwala osokoneza bongo , ndipo si mankhwala opatsirana pogonana kapena anti-seizure , omwe amachititsa kukhala osiyana kwambiri ndi mankhwala ena ogwiritsira ntchito fibromyalgia .
Adeona adanena kuti akuyembekeza kusonyeza kuti mankhwalawa amachiritsidwa kuposa kupwetekedwa kwa fibromyalgia, komanso amachepetsa nkhawa, kutopa, mavuto amalingaliro, kusokonezeka kugona komanso ntchito zogwirira ntchito.
Mankhwalawa amasiyana mosiyana ndi mankhwala opweteka kwambiri chifukwa cha momwe amachitira zowawa m'maganizo.
Opiates , omwe kawirikawiri sagwira ntchito mwa anthu omwe ali ndi fibromyalgia, kwezani mlingo wanu wa dopamine, zomwe zimabweretsa chisangalalo. M'malo moletsa kupweteka, opiates amakupangitsani kusamalidwa kwambiri ndi ululu.
Kumbali ina, imakhala yofatsa pazinthu zina mu ubongo zotchedwa NMDA receptors ndipo, motero, zimachepetsanso ma glutamate . Glutamate ndi mitsempha ya ubongo yomwe imachititsa kuti ubongo wanu ukhale wogwira ntchito.
Zofukufuku zomwe zafalitsidwa mu 2008 ndi 2009 (Harris) zimasonyeza kuti anthu omwe ali ndi fibromyalgia akhoza kukhala ndi ma glutamate ambiri m'madera ena a ubongo komanso kuti pamene magulu a glutamate akugwa, chomwecho ndikumva kupweteka. Izi zimapangitsa kuti oral lipirtine akhale wokongola kwa ife.
Anthu omwe ali ndi fibromyalgia ali ndi nthawi yovuta kwambiri kulekerera mankhwala. Mankhwala omwe amagwiritsidwa ntchito potichitira ife, amakhala ndi ndandanda ya zotsatira zake ndipo zingakhale zovuta kupirira. Dokotala wotchedwa Oral flupirtine wa ku Ulaya monga mankhwala osokoneza bongo omwe ali ndi zotsatira zochepa amachititsanso chidwi. Simusowa kuti mukhale ndi mankhwala osokoneza bongo pang'onopang'ono, monga momwe mumachitira ndi mankhwala omwe amapezeka masiku ano.
Nanga Tsopano?
Zikuwoneka kuti chiyembekezo chathu chokha tsopano ndi chakuti Synthetic kapena kampani ina inayamba kuyamba kufufuza za mouth flupirtine.
Ngakhale ngati zili zovuta, zidzatipindulitsa - kuvomereza kwa FDA kungatanthawuze kuti zidzakhala pamsika ku US ndi madokotala angatipatse ife chizindikiro.
Komabe, zimenezi zimatenga zaka zambiri. Kotero ngati simukufuna kusamukira ku Ulaya, sizikuwoneka ngati mutha kutuluka pakamwa panthawi yomweyo.
Zotsatira:
Harris RE, et al. Arthritis ndi rheumatism. 2008 Mar; 58 (3): 903-7. Magulu amphamvu a glutamate mkati mwa insula akugwirizana ndi kusintha kwa malo ambiri opweteka mu fibromyalgia.
Harris RE, et al. Arthritis ndi rheumatism. 2009 Oct; 60 (10): 3146-52. Malembo amtundu wa glutamate m'kati mwa fibromyalgia amagwiritsidwa ntchito ndi ululu woyesera.