SSRI / SNRI Kuponderezedwa kwa Fibromyalgia, Chronic Fatigue Syndrome

by Adrienne Dellwo; Yofotokozedwa ndi Grant Hughes, MD

Sikuti Akungokhala Kuvutika Maganizo

Pa mankhwala onse a fibromyalgia (FMS) ndi matenda otopa aakulu ( ME / CFS ), kupanikizika kumakhala kovuta kwambiri kwa anthu kuti amvetse. Ziri zachilendo kuti anthu asokonezeke chifukwa chake mankhwalawa amalembedwa kuti azikhala ndi zinthu zina osati kuvutika maganizo.

Komabe, umboni wochulukirapo umasonyeza kuti odwala matenda opatsirana pogonana ndi mankhwala othandiza kwa FMS, ndipo mpaka pang'ono, ME / CFS.

Kuvutika maganizo kumasintha momwe njira zina za ubongo zimagwirira ntchito mu ubongo wanu, ndipo m'maganizo mwanu mumagwirizananso ndi ma Furo, ME / CFS, ndi vuto lalikulu lachisokonezo.

Mitundu iŵiri ya antidepressants yomwe imasonyezedwa kuti ikugwira bwino ntchito zolimbana ndi zizindikiro za FMS ndi:

Serveonin Reuptake Inhibitors (SSRIs)
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

SSRIs ndi SNRI ndi chiyani?

Serotonin ndi norepinephrine onse amadzimadzi a ubongo m'maganizo omwe amafalitsa mauthenga ochokera ku neuron imodzi (brain cell) kupita ku wina. Aliyense amagwira ntchito zosiyanasiyana.

Ntchito za Serotonin zimaphatikizapo kupweteka kwapweteka komanso mbali yowonongeka. Ubongo wanu umagwiritsa ntchito serotonin kupanga melatonin, zomwe zimakuthandizani kugona.

Norephinephrine imakhudzidwa ndi kukhumudwa kwa thupi, kusamala, ndi kukumbukira. Ubongo wanu umagwiritsa ntchito norepinephrine kuti apange neurotransmitter dopamine yomwe imakhudza maganizo, zolinga, ndi kugwirizana.

Zizoloŵezi za serotonin ndi norepinephrine zimakhulupirira kuti zimagwirizana ndi zina za FMS ndi ME / CFS. SSRIs / SNRI zimapanga zambiri mwazokha pochepetsa kuchepetsa kubwezeretsa, zomwe zimakhala ngati zimagwiritsidwa ntchito pambuyo poti zitha kugwiritsidwa ntchito. (Pezani zambiri zambiri: Kumvetsa Reuptake .)

Mwa mankhwala ovomerezeka a FDA a FMS, awiri mwa atatu ali SNRIs.

(Palibe mankhwala omwe ali a FDA-omwe amavomerezedwa ku ME / CFS.) Iwo ndi:

Ma SNRI ena ali pamsika ndipo akhoza kulamulidwa kuchoka pamalopo chifukwa cha matendawa. Zikuphatikizapo:

Effexor (venlafaxine)
Pristiq (desvenlafaxine)

SSRI, zomwe nthawi zina zimatchulidwa kuchoka pa label, zimaphatikizapo:

Celexa (citalopram)
Lexapro (escitalopram)
Luvox (fluvoxamine)
Paxil / Pexeva (paroxetine)
Prozac / Sarafem / Selfemra / Rapiflux (fluoxetine)
Zoloft (sertraline)

Zoopsa: Serotonin Syndrome

SSRIs, SNRIs, ndi mankhwala ena omwe amachulukitsa serotonin amatha kukhala ndi chikhalidwe choopsa chomwe chimatchedwa serotonin syndrome. Vuto limakula pamene mutenga mankhwala owonjezera a serotonin omwe angaphatikizepo mankhwala opatsirana, mankhwala osokoneza bongo komanso zowonjezereka.

Kuti muchepetse chiopsezo cha matenda a serotonin, ndizofunika kuti muuze dokotala ndi wazamankhwala za chirichonse chomwe mukuchita.

Mukhoza kudziwa zambiri zokhudza matenda a serotonin, kuphatikizapo mankhwala ndi zakudya zina zotani zomwe zimakhudza serotonin ndi zizindikiro ziti zomwe muyenera kuziyang'anira, apa: Serotonin Syndrome

Ngozi: Kudzipha

SSRIs, SNRIs, ndi zina zonse zowonongeka zimapatsidwa udindo ndi FDA kuti azitsatira chenjezo lakuda-bungwe lochenjeza kwambiri - pangozi yowonjezereka yodzipha kapena malingaliro odzipha ndi makhalidwe.

Ndikofunika kuti wina aliyense atenge mankhwalawa kuti adziŵe za chiopsezo, komanso ndizofunikira kuti abwenzi ndi achibale adziwe za izo. Iwo akhoza kukhala omwe amawona zizindikiro zochenjeza.

Ngati mukupeza kuti muli ndi maganizo odzipha, funsani nthawi yomweyo. Kuchokera kulikonse ku United States, mukhoza kuitana 1-800-273-8255.

Ndiyo payline ya VA, koma aliyense ali olandiridwa kuyitanidwa. Muyeneranso kuyankhula ndi dokotala wanu za malingaliro awa komanso ngati mukuyenera kumwa mankhwala.

Nazi njira zowonongolera kudzipha:

Information za FDA kwa Othandizira Zaumoyo
Mavuto a Kudzipha (US): 1-800-784-2433 kapena 1-800-273-8255

Zizindikiro Zozipha Zodzipha
Mmene Mungathandizire Munthu Wodzipha

Zoopsa: Kutaya

Kutuluka kwa SSRIs / SNRIs kumadzetsa zoopsa zake. Kuthamanga mofulumira kungayambitse zomwe zimatchedwa syontrome syndrome, kotero muyenera kulankhula ndi adokotala za njira yolondola kuti pang'onopang'ono mutaya mankhwala.

Zizindikiro za matenda osokonekera ndi awa:

Kutopa
Kupweteka kwa minofu
Nausea
Kupweteka kwa minofu
Kusagona
Nkhawa ndi kusokonezeka
Chizungulire
Hallucinations
Masomphenya obisika
Kukhumudwa
Kusinkhasinkha
Maloto omveka
Kutuluka thukuta kwambiri
Kusokonezeka kwa magetsi

Zizindikiro zotsalira zikhoza kukhala zochepa mpaka zofooketsa. Chifukwa chakuti zizindikiro zambirizi ndizofala mu FMS ndi ME / CFS, mukhoza kuwasocheretsa zizindikiro za matenda anu omwe akukula pamene mukusiya mankhwala. Lembani dokotala wanu ngati muli ndi nkhaŵa iliyonse.

Zinthu zina zingathandize kuchepetsa zizindikiro zotsalira. Mukhoza kuphunzira za iwo m'nkhaniyi kuchokera ku malo ovutika maganizo: Zokuthandizani Kuthetsa Zizindikiro Zotsutsa

Ngozi: Zotsatira Zowopsya & Kuyanjana

Mankhwala awa amabwera ndi mndandanda wautali wa zotsatira zake. Zina mwazoopsa kwambiri ndi monga kugwidwa, kulumikiza ndi kuchita zolaula.

SSRIs / SNRIs ikhoza kugwirizana mosagwirizana ndi mankhwala ena osati omwe amachulukitsa serotonin. Izi zingaphatikizepo anti-inflammatories (NSAIDs), ochepa magazi, ndi ena ambiri.

Zotsatirapo ndi kuyanjana zimasiyana ndi mankhwala. Kuti muwone mankhwala enaake, mukhoza kuwoneka pa Drugs.com kapena RxList.com. Amakhalanso ndi mauthenga ambiri.

Kuchepetsa Vuto Lanu

Njira yabwino kwambiri yochepetsera kuopsa kwa SSRIs / SNRIs ndiyo kutsatira mosamala malangizo a dokotala ndi a madokotala kwa mlingo wonse ndi kuyeretsa. Ngati mwadzidzidzi mungathe kulemba mndandanda wa mankhwala anu m'chikwama chanu.

Zikhoza kusindikiza mndandanda wa zotsatira zowonongeka ndikuziika kwinakwake powonekera, makamaka mukayambitsa mankhwala atsopano. Mwanjira imeneyo, mudzatha kuona mwamsanga ngati zizindikiro zatsopano zomwe mukukumana nazo zingakhale zomangirizidwa ku mankhwala.

Kodi SSRI / SNRI Ndi Zolondola Kwa Inu?

Kusankha kutenga SSRIs kapena SNRIs kumapangidwa bwino ndi inu ndi dokotala wanu, mukuganizira za matenda anu, zizindikiro, thanzi lanu lonse, ndi moyo wanu.

Mungafunike kuyesa mankhwala osiyanasiyana mu kalasiyi musanayambe kupeza zomwe zimakuyenderani bwino komanso zomwe mungathe kuzipirira. Izi zingatenge nthawi yochuluka. Onetsetsani kuti mukulankhulana ndi dokotala mutseguka panthawiyi.

_Zotsatira:

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_{Choy EH, et al.} _Kachipatala. _{2009 Sep; 28 (9): 1035-44.} _{Doloxetine ndi zotetezeka komanso zolekerera pochiza odwala omwe ali ndi fibromyalgia: kufotokozera deta kuchokera ku mayesero asanu.}

_{Derry S, et al.} _{Msonkhano wa Cochrane wa ndemanga zowonongeka.} _{2012 Mar 14; 3: CD008244.} _{Milnacipran chifukwa cha ululu wa mtima ndi fibromyalgia mwa akuluakulu.}

_{NIH Publication NO.} _04-5326.

_{Nishiyori M, et al.} _{Kupweteka kwa m'mimba.} _{2011 Sep 21; 7: 69.} _{Mpumulo wamuyaya wa kupsinjika kwachisokonezo-chomwe chimapangitsa fibromyalgia-ngati ululu wosadziwika ndi kachitidwe kawiri kawiri kosokoneza maganizo.}

_{Saxe PA, ndi al.} _{Kafukufuku wamakono ndi maganizo.} _{2012 Mar 19. Nthawi Yochepa (2-Sabata) Zotsatira za kuchoka Milnacipran kwa Odwala ndi Fibromyalgia.}

_{US Food and Drug Administration.} _{"Kukhala ndi Fibromyalgia" Kumapezeka mu March 2012.}

_{Warner, Christopher H, et al.} _{American Family Physician.} _{2006 Aug 1; 74 (3): 449-56.} _{Kugonjetsa Kuchokera Kwachilendo.}