Kuchiritsa Kwambiri Kumasonyeza Lonjezo
Mwachidule
Naltrexone ndi mankhwala omwe, pa mlingo wokwanira wa 50 mpaka 100 mg, amaletsa zotsatira za opioids. Komabe, pamadzi otsika kwambiri, ofufuza ena amakhulupirira kuti mankhwalawa angakhale opindulitsa kwa anthu omwe ali ndi fibromyalgia ndi matenda operewera ; Matenda omwe amatha kupweteka / kuphwanyiranso kuphatikizapo ziwalo zambiri zowawa, matenda ovuta a m'madera ammudzi, ndi Crohn's disease; ndi matenda ena okhudzana ndi chitetezo cha mthupi, monga HIV / AIDS .
Mlingo wochepa wotchedwa naltrexone (LDN) ndi mankhwala osakwera mtengo omwe ali kale pamsika, zomwe zachititsa kuti zisangalalo zogwiritsidwa ntchito. Kafukufuku akuyenda pang'onopang'ono, komabe chifukwa chakuti palibe ndalama zambiri zolimbikitsa.
Kodi LDN Zimagwira Ntchito Bwanji?
Ochita kafukufuku samvetsetsa momwe ntchitoyi ikugwirira ntchito. Akatswiri ena amanena kuti LDN imateteza mapulogalamu ena m'matenda omwe amachititsa kuti zizindikiro za fibromyalgia ndi matenda otopa zikhale zovuta.
Umboni wina umasonyeza kuti LDN imagwira ntchito ngati anti-inflammatory pakatikati ndi pena njira zamanjenje, mwinamwake pochepetsa ntchito ya maselo apadera otchedwa microglia.
Kafukufuku akuwonetsanso kuti LDN ikhoza kuthandizira kuonetsetsa kuti chitetezo cha m'thupi chimasintha, zomwe zingakhale chifukwa chake zikuwoneka kuti zathandiza anthu omwe ali ndi matenda omwe amateteza thupi lawo.
Phunzirani zambiri za kutupa ndi kudzimitsa thupi mu fibromyalgia ndi matenda otopa aakulu:
Kwa Fibromyalgia
Kafukufuku wa Sunivesite ya Stanford wasonyeza zotsatira zabwino-pafupifupi kuchepa kwa makumi atatu pa zizindikiro poyerekeza ndi placebo. Ochita kafukufuku amanena kuti zotsatira ndi zabwino kwa anthu omwe ali ndi chiwerengero chokwanira kwambiri, chomwe chimasonyeza kupweteka kwa thupi m'thupi.
(A high sed rate angasonyeze chikhalidwe chogwedezeka chifukwa sichikwera pamwamba pa fibromyalgia.)
Zotsatira zimasonyezanso kuti mankhwalawa amalekerera.
Komabe, maphunzirowa akhala akuchepa ndipo ntchito zambiri ziyenera kuchitika tisanadziwe kuti LDN ndi yotetezeka bwanji.
LDN si FDA yomwe imavomerezedwa ku fibromyalgia koma nthawi zina imatumizidwa kuchoka pamalopo.
Kuchokera Kwambiri Kutopa
Pakalipano, LDN siinaphunzirepo za matenda osatopa. Komabe, madokotala ena ndi odwala amanena kuti agwiritsa ntchito bwino.
Ndi umboni wam'mbuyo umene ukuwonetsa kuti kuthekera kwa matenda osokoneza bongo ndi matenda a LDN amachititsa kuti kutupa mu dongosolo lamanjenje, tikhoza kuona chifukwa ichi ndi chithandizo chabwino kwa ena.
Monga momwe amagwiritsira ntchito fibromyalgia, nthawi zina LDN imatumizidwa kuchoka ku-label chifukwa cha kutopa kwa matenda aakulu.
Mlingo
Kuti agwiritsidwe ntchito pochiza fibromyalgia kapena matenda otopa matenda, naltrexone kawirikawiri amapatsidwa mlingo wa 4.5 mg kapena zochepa. Kawirikawiri, mutha kuyamba pa 1.5 mg, kugwiritsira ntchito 3 mg, ndikuwonjezeka ku 4.5.
Zotsatira zomwe zimayesedwa ndi mlingo wotsikawu sichikuwoneka pa mlingo waukulu.
Zotsatira Zotsatira
Ngakhale kuti LDN ikuwoneka bwino, zotsatira zake za naltrexone zikuphatikizapo:
- chizungulire & syncope (kutaya)
- mutu
- kusowa tulo
- nkhawa ndi mantha
- kugona & kutopa
- kunyozetsa, kusanza, kutsekula m'mimba, kupweteka m'mimba / kuponda, kuchepa kwa njala
- jekeseni ya jekeseni ndi kutupa
- ululu wamkati
- kupweteka kwa minofu kwambiri
- matenda opatsirana apamwamba
- chikhure
Mu maphunziro a Stanford, zotsatirapo zinawoneka ngati zosawerengeka, zofatsa, ndi zosakhalitsa.
Anthu omwe ali ndi impso kapena matenda a chiwindi angafunike mayeso apadera kapena mayesero kuti atenge LDN bwinobwino. Mankhwalawa akhoza kukhala owopsa kwa mwana wosabadwa. Sitikudziwabe ngati chikudutsa mkaka wa m'mawere.
LDN ndi Opioid Painkillers
Pakamwa kwakukulu, naltrexone imagwiritsidwa ntchito kwa anthu okalamba omwe amachokera ku opiate (mankhwala osokoneza bongo) omwe amachititsa kuti azimayi asokonezeke ngati Vicodin (hydrocodone acetaminophen) ndi OxyContin (oxycodone) chifukwa amalepheretsa ubongo.
Zotsatira zake zogwiritsira ntchito opiate pazitsitsi zochepa sizidziwikabe, koma zimaonedwa kuti ndizolakwika kugwirizanitsa mankhwalawa. Onetsetsani kuti mungalankhule ndi dokotala wanu za nthawi yayitali bwanji musanayambe LDN.
Kodi N'koyenera kwa Inu?
Ngati mukufuna kuyesa LDN, lankhulani ndi dokotala wanu za zomwe zingatheke komanso zoyipa. Ngakhale madokotala ena amapereka LDN kwa anthu omwe ali ndi matendawa ndi ena ambiri, iwo akuwonekeratu kuti akuchiritsidwa, kotero dokotala wanu sangakhale wofunitsitsa kuziganizira.
Zotsatira:
Ablin JN, Buskila D. Maganizo a akatswiri okhudza mankhwala osokoneza bongo. 2010 Sep; 15 (3): 521-33. Mankhwala othandiza a fibromyalgia: chosinthika.
Plesner KB, Vaegter HB, Handberg G. Ugeskrift kwa laeger. 2015 Oct 9; 177 (43): V03150248. Mlingo wochepa umapangitsanso mankhwalawa. [Chithunzi chofotokozedwa. Nkhani mu Danish.]
Wachichepere J, Mackey S. Mankhwala opweteka. 2009 May-Jun; 10 (4): 663-72. "Zizindikiro za Fibromyalgia Zimachepetsedwa ndi Naltrexone Yoperewera: Phunziro Lophunzira."
Mnyamata J, et al. Arthritis ndi rheumatism. 2013 Feb; 65 (2): 529-38. Mankhwala ochepa amachititsa kuti mankhwala a fibromyalgia asamangidwe: kupeza zochepa, zosaoneka bwino, ziwiri, zam'katimbiri, zoyenerera, zoyenerera, zoyesa kupweteka kwa tsiku ndi tsiku.
Wachichepere J, Parkitny L, McLain D. Clinical rheumatology. 2014 Apr; 33 (4): 451-9. Kugwiritsa ntchito mlingo wotsika naltrexone (LDN) monga mankhwala atsopano oletsa-kutupa kwa kupweteka kosatha.