Kodi Glutamate ndi chiyani?
Tanthauzo:
Glutamate ndi mtundu wa mankhwala a ubongo wotchedwa neurotransmitter , kutanthauza kuti zimathandiza kutumiza mauthenga ozungulira ubongo. Nthawi zambiri zimaphatikizapo kuphunzira ndi kukumbukira. Glutamate imakhudzanso matenda ambiri a ubongo.
Komanso: L-glutamic acid, glutamic acid, L-glutamate
Kawirikawiri Kusokonezeka Ndi: Glutamine
Glutamate amachita ntchito zina zofunika mu ubongo wanu.
Zimatengedwa kuti ndizodzipatula, zomwe zikutanthauza kuti zimayambitsa malo mu ubongo kapena mbali zina za mitsempha. Kulimbikitsa kotereku ndi mbali yofunikira pa kuphunzira, moteronso, glutamate ndi chinthu chabwino.
Komabe, zambiri za glutamate sizinthu zomwe mukufuna. Nthawi zina, ikhoza kukhala chomwe chimatchedwa excitotoxin. "Toxin" sichitha kukhala mawu abwino, ndipo ndithudi sizowoneka bwino. Mu udindo wake monga excitotoxin, glutamate ikhoza kugonjetsa maselo a ubongo wanu.
Ngati miyezo yapamwamba ikusasinthika, khungu la khunyu limatha kupitirira maselo awo mopitirira muyeso mpaka atachita mwamphamvu ndikupanga kudzipha kwa maselo kuti ateteze maselo owazinga. (Taganizirani izi ngati kutenga dzino lovunda kotero kuti kuvunda sikufalikira kwa mano pafupi ndi icho.)
Maselo m'thupi lathu amafa nthawi zonse, ndipo ambiri mwa iwo amatha kuwongolera. Komabe, omwe glutamate amachititsa kuti adziphe, ndiwo neurons.
Ubongo wanu sungapange zatsopano m'malo mwa zomwe zatayika, choncho ndizofunika kuti azisunga thanzi lawo.
Udindo wa Glutamate monga excitotoxin umakhulupirira kuti umakhudzidwa ndi matenda osiyanasiyana monga matenda a multiple sclerosis, Alzheimer's disease ndi amyotrophic lateral sclerosis (yotchedwa ALS kapena Lou Gherig).
Kugwilitsika kwa Glutamate kumagwirizananso kuti ndi mbali ya fibromyalgia ndi matenda otopa , ngakhale kuti izi sizingaganizidwe kuti ndizovuta.
Glutamate & Fibromyalgia
Kafukufuku amasonyeza kuti anthu omwe ali ndi fibromyalgia amakhala ndi malo otchuka a glutamate m'dera la ubongo wotchedwa insula kapena insular cortex. Chilumbachi chimakhudzidwa kwambiri pakukonza ululu ndi zowawa zonse. Magulu okwera a glutamate ndi chizindikiro chakuti dera lino la ubongo lingakhale lopitirira kwambiri mu chikhalidwe ichi.
Nkhalangoyi imathandizanso:
- malingaliro
- nkhawa
- luso lamagetsi
- zikhumbo
- vuto la kudya
- kuledzera
Mu fibromyalgia, zowonjezereka zowonjezera zingakhale zowonjezereka, zomwe zimapangitsa kuwonjezereka . Nkhawa ndi chizindikiro chofala / chikhalidwe chofala. Maluso amatha kukhala osokonezeka, omwe amachititsa kuthetsa mavuto ndi kugwa . Matenda odya angakhale ofala kwambiri kwa anthu omwe ali ndi fibromyalgia, komanso.
Glutamate alipo m'madera a thupi kunja kwa dongosolo la mitsempha, kumene limagwira ngati hormone. Pa ntchito imeneyi, ikhoza kupweteka.
Phunziro la 2016 limasonyeza kuti kuchita masewera olimbitsa thupi kungachepetse ululu wokhudzana ndi glutamate kwa anthu omwe ali ndi fibromyalgia, zomwe zingathandize kufotokoza kugwirizana kosamvetsetseka pakati pa vutoli ndi kuyesayesa .
Glutamate mu Chronicle Fatigue Syndrome
Kafukufuku akugawanitsa ngati matenda a glutamate amachititsa kuti munthu asatope matenda aakulu, zomwe zimaphatikizaponso mavuto okhudzidwa, nkhawa, ndi mavuto .
Koma mosiyana ndi fibromyalgia, kafukufuku amasonyeza kuti ma glutamate angakhale otsika m'madera ena a ubongo. Izi zimakhala zomveka mukamaganizira za ubongo wa ubongo zomwe zikugwirizana ndi matendawa, zomwe zimaphatikizapo mavuto ndi kuphunzira.
Tili ndi umboni wina wosonyeza kuti kutopa kwa matenda aakulu kumaphatikizapo majini omwe ali ogwirizana ndi glutamate dysregulation.
Monosodium Glutamate
Monga amino acid, glutamate ndi mbali ya monosodium glutamate (MSG), yomwe imagwiritsidwa ntchito m'ma mankhwala ena monga chakudya chowonjezera.
Zingakhale zokhudzana ndi mavuto ena oipa.
Madokotala ena amakhulupirira kuti MSG ikhoza kuvulaza anthu omwe ali ndi fibromyalgia, pamene ena amakhulupirira kuti si. Anthu ena amanena kuti kuchotsa MSG ku zakudya zawo zathandiza kuchepetsa zizindikiro za matenda a fibromyalgia ndi matenda otopa, koma izi sizitsimikiziridwa ndi sayansi ya zamankhwala.
Glutamate & Other Neurotransmitters
Mwinamwake mumadabwa mmene ubongo wanu umayendera ndi glutamate. Ili ndi njira yothetsera vutoli-winanso wotchedwa neurotransmitter wotchedwa GABA. Ntchito ya GABA ndikutonthoza ubongo wanu mutatha kulemera kwa glutamate.
Ndikofunika kuti GABA ndi magulu a glutamate akhale olingana wina ndi mzake, koma nthawi zambiri sizili choncho mu matenda okhudzana ndi glutamate.
Othandizira ena ogwira ntchito m'maganizo amenewa akuphatikizapo:
Hannestad U, Theodorsson E, Evengård B. Magazini ya International of chemisty chemisty. 2007 Feb, 376 (1-2): 23-9. beta-Alanine ndi gamma-aminobutyric asidi mu matenda aakulu otopa.
Harris RE, ndi. al. Arthritis ndi rheumatism. 2009 Oct; 60 (10): 3146-52. Malembo amtundu wa glutamate m'kati mwa fibromyalgia amagwiritsidwa ntchito ndi ululu woyesera.
Kuratsune H, Yamaguti K, Lindh G, et al. NeuroImage. > 2002 Nov; 17 (3): 1256-65. Madera a ubongo omwe amawathandiza kuti asatope: amachepetsa ubongo wa acetylcarnitine mu ubongo.
> Martins DF, Siteneski A, Ludtke DD, et al. Matenda a m'magazi. 2016 Sep 13. [Epub patsogolo pa kusindikiza] Kuchita masewera olimbitsa thupi kumachepetsanso njira zowonongeka za glutamate mwa kuyambitsa mapuloteni a g-mapuloteni omwe amaletsa phosphorylated protein kinase a.
Smith AK, Fang H, Whistler T, ndi al. Neuropsychobiology. > 2011; 64 (4): 183-94. Maphunziro okhudza kusintha kwa thupi amadziwika kuti bungwe la GRIK2 ndi NPAS2 lomwe liri ndi matenda aakulu.