Ntchito Zomwe Amachita, Ndi Mavuto Otani Amene Amayambitsa
GABA ndi glutamate ndizomwe zimagwira ntchito mu ubongo wanu. Mmodzi akukhazika mtima pansi, imodzi imalimbikitsa, ndipo amayenera kukhala olingana wina ndi mzake. Ndiye chimachitika ndi chiani ngati mutayika bwino?
Kafukufuku wina amasonyeza kuti kusagwirizana kwa zinthu ziwirizi kungathandize kwambiri mu fibromyalgia (FMS). Kafukufuku sakhala wolimba pochita nawo nawo matenda otopa ( ME / CFS ), ndi maphunziro ena akutsutsa umboni wa kusemphana maganizo ndi ena osapeza kanthu.
Mu Ubongo Wanu
Ubongo waumunthu ndi wovuta kwambiri. Mphuphu iliyonse imagwira ntchito zosiyanasiyana, ndipo imayanjana ndi makina anu (ubongo) m'njira yovuta yomwe sitikumvetsa bwino.
Komabe, timaphunzira zambiri za ubongo ndi ofufuza athandiza kugwirizanitsa matenda enaake a matendawa ndi matenda ena kapena zizindikiro. Iwo apeze njira zothetsera ntchito ya neurotransmitter ndipo amatha kuona zotsatira zomwe zilipo pazofukufuku.
Ubongo ndi wokonzanso bwino, nthawi zambiri pogwiritsa ntchito neurotransmitter imodzi kuti apange china. Ntchitoyi imapangitsa kuti muzimvetsetsa kwambiri pamene mukukamba za odwala matendawa omwe ali ndi ntchito zosiyana, monga GABA ndi glutamate. Serotonin yotchuka kwambiri ndi awiriwa ndi chitsanzo china, monga norepinephrine ndi dopamine. Zonsezi zimakhulupirira kuti zimasokonezedwa muzinthu izi.
Pamene mphuno imodzi yokhala ndi mapuloteni muwiri iwiri yaying'ono, ikhoza kuponyera winayo, komanso.
Glutamate
Glutamate ndi mtundu wa ubongo wanu. Imodzi mwa ntchito zake zoyambirira ndikuti maselo ena a ubongo athamangitsidwe. Zimalimbikitsa iwo kuti athe kuchita zinthu zofunika monga kuphunzira zatsopano kapena kukumbukira zinthu zina zomwe glutamate zimakhudzidwa.
Komabe, wokondwa yemwe samaima kukupangitsani kuti muzinena zinthu amakhumudwa pakapita kanthawi. Zambiri zowonjezera si chinthu chabwino, monga aliyense amene aledzera kwambiri khofi angakuuzeni. Nthawi zina, glutamate ikhoza kukhala chomwe chimatchedwa "excitotoxin," kutanthauza kuti nthawi zina zimawoneka kuti zimapitirira-kukondweretsa mitsempha mpaka atadzipha.
Kukhoza kumayambitsa imfa ya maselo a ubongo ndichifukwa chake amakhulupirira kuti glutamate imakhudzidwa ndi matenda ena a ubongo monga Alzheimer's and amyotrophic lateral sclerosis (ALS kapena matenda a Lou Gehrig). (Dziwani: FMS ndi ME / CFS sakhulupirira kuti zikhoza kuwonongeka.)
Mu FMS, kafukufuku amasonyeza kuti anthu ambiri ali ndi ubongo wa glutamate m'mbali mwa ubongo wotchedwa insula kapena insular cortex. Ochita kafukufuku anapita kukayang'ana kumeneko chifukwa dera limeneli limakhudzidwa kwambiri ndi ululu ndi maganizo, zomwe ndizo zigawo zikuluzikulu za chikhalidwe. Chilumbachi chimakhudzidwanso ndi malingaliro, zamagalimoto, nkhawa, matenda odwala, ndi kuledzera.
Kafukufuku wathandizanso kugwirizanitsa makulu a glutamate ndi kupsinjika maganizo ndi ntchito yochepetsetsa kwa anthu omwe ali ndi matenda a shuga. (Glutamate ingachokere ku shuga, yomwe nthawi zambiri imakhala ndi anthu odwala matenda ashuga.) Kafukufuku umodzi wa FMS watsimikizira kuti kuchepetsa magulu a glutamate kungachepetse ululu.
Kuwonjezera apo ubongo glutamate amakhulupirira kuti amachititsa zizindikiro zambiri, kuphatikizapo:
- hyperalgesia (kupweteka kupweteka, chinthu chachikulu cha FMS)
- nkhawa
- kupuma
- Zizindikiro zofanana ndi ADHD, monga kusakhoza kuganizira
Mu ME / CFS, ofufuza ena amaganiza kuti ntchito ya glutamate ndi yochepa, zomwe zimatanthauza kuti ubongo sichikukakamiza mokwanira. Komabe, chikhulupiriro ichi sichinavomerezedwe ndi umboni.
Kulephera kwa glutamate mu ubongo kumakhulupirira kuti zimayambitsa zizindikiro kuphatikizapo:
- kusowa tulo
- mavuto
- kufooka maganizo
- mphamvu zochepa
GABA
GABA amaimira gamma-amino-n-butyric asidi. Ubongo wanu umagwiritsa ntchito glutamate kuti ukhale ndi GABA.
Ntchito yaikulu ya GABA ndikutontholetsa ubongo wanu.
Zimakhudzidwanso mu tulo, zosangalatsa, malamulo okhudzidwa ndi minofu.
GABA amakhulupirira kuti ndi yotsika kapena yosagwiritsidwa ntchito mosagwiritsidwa ntchito mu FMS. Pakadali pano, kufufuza sikukutanthauza kuti GABA kudetsedwa mu ME / CFS.
Chifukwa cha GABA ndi ubale wapamtima, zizindikiro za ubongo wa GABA zingafanane, kapena zimagwirizana ndi, za ubongo glutamate owonjezera.
Kupeza Kusamala
Ngati mukuganiza kuti GABA / glutamate dysregulation ikuyambitsa zizindikiro zina, lankhulani ndi dokotalayo za izo. Pali mankhwala, zowonjezereka, komanso kusintha kwa zakudya zomwe zingakuthandizeni kupeza bwino. Mukhoza kufufuza njirazi apa:
Zotsatira:
Hannestad U, Theodorsson E, Evengård B. Magazini ya International of chemisty chemisty. 2007 Feb, 376 (1-2): 23-9. Epub 2006 Jul 14. beta-Alanine ndi gamma-aminobutyric asidi mu matenda aakulu.
Harris RE, ndi. al. Arthritis ndi rheumatism. 2009 Oct; 60 (10): 3146-52. Malembo amtundu wa glutamate m'kati mwa fibromyalgia amagwiritsidwa ntchito ndi ululu woyesera.
Harris RE, ndi. al. Arthritis ndi rheumatism. 2008 Mar; 58 (3): 903-7. Magulu amphamvu a glutamate mkati mwa insula akugwirizana ndi kusintha kwa malo ambiri opweteka mu fibromyalgia.
> Lyoo IK, ndi. al. Archives of psychiatry. 2009 Aug; 66 (8): 878-87. Mitengo yowonongeka ya glutamate-glutamine-gamma-aminobutyric asidi komanso yogwirizana ndi chidziwitso chochepa cha matenda a shuga.
Murrough JW, et. al. NMR mu biomedicine. 2010 Jul; 23 (6): 643-50. Kuchulukitsa lactate m'mimba mwachilendo matenda olemetsa oyeza 1H MRS pa 3.0 T. II: kuyerekezera ndi matenda aakulu ovutika maganizo.