Yang'anani pa Zosankha Zanu
Mankhwala am'thupi ambiri (amithenga am'kati mu ubongo) amatha kusokonezeka mu fibromyalgia (FMS) ndi matenda osatopa ( ME / CFS ). Pamene mukumva zambiri za serotonin ndi norepinephrine, ena angapo angakhalenso ochepa.
GABA ndi ma glutamate onse amadzimadzi amaoneka ngati akuphatikizidwa mu FMS ndi ME / CFS. Magulu a Glutamate kapena ntchito ikuwonekera kuti ndi yapamwamba, pamene miyezo ya GABA kapena ntchito ikuoneka kuti ndi yochepa.
Glutamate imayambitsa-ndipo ikhoza kugonjetsa-ubongo wanu, pamene GABA imawombera pansi. Kusiyanitsa kwawo kungakhale ndi udindo, makamaka mbali, chifukwa cha nkhawa yomwe ikugwirizana ndi izi ndi zizindikiro zina. (Kuti mudziwe zambiri, onani GABA & Glutamate: Part 1. )
Kusintha zochita kwa odwala matendawa kumathandiza kuchepetsa zizindikiro.
Zakudya ndi Zowonjezera kwa GABA / Glutamate Function
Zowonjezera kusintha kwa ntchito ya GABA ndi glutamate mu ubongo wanu sizinaphunzire mwachindunji kwa FMS ndi ME / CFS, koma tili ndi chidziwitso chodziwikiratu.
GABA yothandizira ya GABA ilipo ngati yowonjezera. Komabe, lingaliro lamakono lachipatala ndiloti siloloka malire a ubongo-ubongo (BBB) kotero sichichita kanthu kuti athetse kusamvana kwa chiwalo cha mpweya.
Chodabwitsa n'chakuti, mukhoza kuonjezera kupanga GABA mwa kuwonjezeka kwa glutamate, popeza thupi lanu limagwiritsa ntchito glutamate kuti likhale ndi GABA.
Kuonjezera kukulitsa kwa glutamate, kungakuthandizeni kuwonjezera zowonjezereka za glutamate (zomwe thupi lanu limagwiritsa ntchito kuti lizipange) ku zakudya zanu kapena zakudya zina.
Zina mwazitsulo zikuphatikizapo:
- 5-HTP : Thupi lanu limatembenuza 5-HTP kukhala serotonin, ndipo serotonin ikhoza kuyambitsa ntchito ya GABA. 5-HTP ndi mawonekedwe a tryptophan, omwe amapezeka mu Turkey. Komabe, malo opangira chakudya a tryptophan saganiziridwa kuwoloka BBB momwe 5-HTP imachitira.
- Glutamine: Thupi lanu limatembenuza amino acid mu glutamate. Glutamine amapezeka mu mawonekedwe owonjezera ndipo amakhala mu nyama, nsomba, mazira, mkaka, tirigu ndi masamba.
- Taurine: Amino acid awawonetsedwa mu makoswe kuti asinthe mavoti a ubongo a GABA ndi glutamate. Mutha kutenga izo mu mawonekedwe owonjezera ndikuzitenga mwachibadwa ku nyama ndi zodyera. Kawirikawiri Taurine imayikidwa ku zakumwa zakumwa.
- Theanine : Chotsatira cha glutamate chikuwoneka ngati kuchepetsa ntchito ya glutamate mu ubongo mwa kulepheretsa mapulogalamu obvomerezeka komanso kupititsa patsogolo magulu a GABA. Amapezeka mwachibadwa mu tiyi komanso amapezeka ngati chowonjezera.
Pulojekiti yotchedwa Lactobacillus rhamnosus ingasinthe ntchito ya GABA mu ubongo wanu, malinga ndi phunziro la 2011. Akatswiri amanena kuti mbewa zomwe zinadya mabakiteriya zinali ndi nkhaŵa zochepa poika m'masautso. Komabe, izi zimafuna kufufuza zambiri zisanachitike.
Musanayambe kudya zakudya zatsopano kapena kupanga zakudya zowonjezereka, kambiranani ndi dokotala ndi wazamankhwala za zoopsa zomwe mungagwiritse ntchito . Kuti mudziwe zambiri poyambitsa zowonjezereka, onani: 7 Zinthu Zomwe Muyenera Kudziwa Zokhudza Zowonjezera .
Mankhwala omwe amachititsa GABA ndi Ntchito ya Glutamate mu ubongo
Mankhwala ambili pakali pano pamsika amasintha zochita za ubongo za GABA ndi glutamate.
Ambiri ayesedwa ndipo / kapena amagwiritsidwa ntchito monga mankhwala a FMS, koma a ME / CFS osachepera.
Mankhwala awa amatchedwa agonists. Sizimayambitsa mapiritsi a mphuno koma amachititsa kuti ntchito zikhale zolimbikitsa. Kwenikweni, amachititsa ubongo wanu kugwiritsira ntchito zambiri zomwe zilipo kale.
GABA agonists ndi awa:
- Benzodiazepines: Mankhwalawa amachititsa kuti thupi liziyenda bwino. Ambiri a benzodiazepines ndi Ativan (lorazepam), Klonopin (clonazepam), Valium (diazepam) ndi Xanax (alprazolam). Nthawi zina Benzodiazepines amalembedwa kwa FMS, makamaka pamene kugona ndi nkhawa zilipo.
- Xyrem (sodium oxbate) & GHB (Gamma-Hydroxybutyric asidi): Mankhwalawa ogwirizana kwambiri amachititsanso kuti asokonezeke kwambiri. Dzina la msewu wa GHB ndi " mankhwala operekera kugwiririra tsiku ." Xyrem imavomerezedwa zizindikiro zina za matenda osokoneza bongo, ndipo maphunziro asonyeza kuti ndi othandiza monga chithandizo cha FMS; Komabe, US Food and Drug Administration (FDA) adaikana ndi FMS chifukwa cha nkhawa.
- Non-Benzodiazepine Hypnotics: Kalasi imeneyi imaphatikizapo mankhwala ogona ogona Ambien (zolpidem), Sonata (zaleplon) ndi Lunesta (eszopiclone). Mankhwalawa ndi osiyana ndi benzodiazepines koma amagwira ntchito mofananamo. Kafukufuku wina (kuphatikizapo Gronblad ndi Moldofsky, m'munsimu) asonyeza kuti mankhwalawa amachititsa kuti tulo tigone bwino komanso mwina ululu mu FMS. Palibe mankhwala awa omwe apita pamaso pa FDA kuti avomereze.
Kodi Yoga Ingapangitse GABA?
Yoga kaŵirikaŵiri amakhulupirira kuti akukhazika mtima pansi. Kodi zikhoza kuwonjezera GABA mu ubongo? Phunziro limodzi laling'ono likusonyeza kuti zingatheke. Ochita kafukufuku anafotokoza kuti 27 peresenti yawonjezeka m'magulu a GABA apakati pa yoga m'magulu asanu ndi atatu.
Izi ndi phunziro limodzi, komabe tikufunikira kufufuza kwina kuti yoga ikulitse ubongo wa GABA komanso ngati ichita zambiri kuposa ntchito zofanana.
Neurotransmitter Dysregulation
Ngati mukukhulupirira kuti muli ndi GABA / glutamate dysregulation, muyenera kulankhula ndi adokotala za njira zomwe mungasankhe. Kumbukirani kuti ngakhale mankhwala achilengedwe angakhale ndi zotsatira zoyipa.
Dziwani zambiri:
Zotsatira:
Bravo JA, ndi. al. Proceedings of the national academy of sciences ya ku United States of America. 2011 Sep 20; 108 (38): 16050-5. Kusakaniza kwa vuto la Lactobacillus kumayendetsa khalidwe la maganizo komanso pakati pa GABA pemphisiti mu mouse pogwiritsa ntchito vagus nerve.
Jacobs GE, ndi. al. Kupititsa patsogolo pa neuro-psychpharmacology ndi matenda a matenda a maganizo. 2010 Apr 16; 34 (3): 486-91. Masamba a gluthalamic glutamate akutsatira mphamvu ya serotonergic.
Malemud CJ. Zolemba zachipatala ndi zoyesera. 2009 Sep-Oct; 27 (Suppl 56): S86-91. Ganizirani njira zopweteka komanso mankhwala opatsirana pogwiritsa ntchito matenda a fibromyalgia.
Molchanova SM, Oja SS, Saransaari P. Zomwe zikuchitika m'madera akumadzulo akumayiko ena. 2007; 50: 95-7. Zotsatira za taurine pamtundu wa glutamate, GABA, glutamine ndi alanine mu khola lopweteka ndi hippocampus.
Spitzer AR, Broadman M. Pain Practice. 2010 Jan-Feb; 10 (1): 54-9. Kuchiza kwa matenda a sleeping narcoleptiform mu matenda aakulu otopa ndi fibromyalgia ndi sodium oxbate.