Zomangamanga & Kulumikizana Kusintha
Lyrica (pregabalin) imasintha maonekedwe a ubongo ndi vutolo mwa anthu omwe ali ndi fibromyalgia , malinga ndi kafukufuku (Piui) wofalitsidwa kumayambiriro kwa 2016.
Lyrica ndi mankhwala oyamba a FDA ovomerezeka ku fibromyalgia. Ndi mankhwala osokoneza bongo, koma amapezanso kuti athetse ululu wa fibromyalgia, matenda a shuga , ndi opaleshoni.
Komabe, momwe izo zimachitira izo siziri bwino.
Kafukufuku watsopanoyi angathandize kufotokoza mmene Lyrica ikuthandizira kuthetsa ululu.
Chiyambi
Mu phunziroli, amayi 16 omwe ali ndi fibromyalgia adadutsa nthawi ziwiri zoyesedwa, zomwe zimagwiritsidwa ntchito mosavuta. Ofufuza anafufuza ubongo wawo pogwiritsa ntchito maginito opanga maginito (FMRI) chithandizo chisanayambe komanso pambuyo pa nthawi iliyonse yoyesedwa.
Iwo anali kuyang'ana mwachindunji pa:
- Vuto lalikulu;
- Kulumikizana pakati pa malo osiyanasiyana pamene ululu umachitika.
Mutu wa ubongo wanu - mitsempha ya neuroni yomwe imatumiza ndi kulandira zizindikiro zamagetsi - mwachibadwa imachepetsanso pamene tikukalamba. Malingana ndi kafukufuku ochepa, zikuwoneka kuti zimachepa mofulumira kwambiri kwa iwo okhala ndi fibromyalgia kusiyana ndi anthu abwinobwino. Pa nthawi yomweyi, kafukufuku wina wasonyeza kuti madera ena ndi aakulu kuposa owerengeka.
Kafukufuku akuwonetsanso zochitika zosazolowereka m'madera a ubongo omwe amachititsa ululu, komanso kugwirizanitsa pakati pa madera osiyanasiyana, zomwe zimasonyeza kuopsa (ndi chikhalidwe chenicheni) cha ululu wa fibromyalgia.
Ochita kafukufuku amakhulupirira kuti izi ndizo zoyamba kufufuza kuyang'ana kusintha kwa mutu wachisoni ndi kukhumudwa kwa anthu omwe amathandizidwa ndi Lyrica.
Zotsatira
Pambuyo pofufuza kafukufuku wam'mbuyomo ndi wam'tsogolo, ofufuza adawona zinthu zambiri zosangalatsa pambuyo pochiritsidwa mu gulu la Lyrica, kuphatikizapo:
- Kuchepetsedwa kwa voliyumu m'madera omwe amakhulupirira kuti ndi ofunikira kupangidwira kupweteka - malo otchedwa posterior insula. Chilumbachi chimakhudzanso kutengeka, homeostasis, ndi zinthu zina zambiri.
- Kuchepetsa mavotolo mu gyrus yomwe ili mkati mwa anthu omwe amawonetsa zowawa zochepa. Dera limeneli likugwirizana ndi ntchito zopambana monga kupanga.
- Kuchepetsa kugwirizanitsa pakati pa zigawo zambiri pamene ululu unalengedwa kupyolera mu kukakamizidwa. Kupeza kumeneku kunayanjananso ndi mauthenga a kuchepetsa kupweteka kwa mankhwala pambuyo pake.
Akatswiri ofufuza anapeza kuti mankhwala a Lyrica afupikitsa amachepetsa kupweteka, mwina mbali imodzi, mofulumira kusintha maonekedwe a ubongo ndi kuyanjanitsa panthawi ya ululu.
Phunziroli likutipatsanso kumvetsetsa bwino kumene malo omwe "vuto" angakhale mu ubongo wa fibromyalgia kotero kuti chithandizo chamtsogolo chidzawathandize.
Zochitika zanga ku Lyrica
Ndinatenga Lyrica kwa miyezi ingapo chaka chimodzi nditapezeka kuti ndine ndi fibromyalgia. Ndiyenera kunena, zotsatirazi zaphunzirira zanga chifukwa cha chinthu china chimene chinachitika nditatha mlingo wanga woyamba.
Pafupifupi maola awiri nditatha kumwa mapiritsi oyambirira, ndimalumbirira kuti ndinamva kumva ngati chinachake chomwe chinali kudutsa mu ubongo wanga. Icho chinali chinthu chodabwitsa kwambiri! Ndisanayambe kumva zimenezi, ndinali ndi ululu wambiri, wouma, komanso wosaganizira.
Pambuyo kumverera kosamvetsetseka, ndinali ndi ululu wochepa kwambiri ndipo ndinakhala wogalamuka kwa nthawi yoyamba muyaya. Usiku umenewo, ndinakhala ndikumva kugona koyenera kwambiri pamoyo wanga, ndipo ndinadzuka ndikutsitsimula. Yatsitsimutsidwa! Izo siziri zachilendo kwa ine. Ndinayamba kuyenda patapita kadzutsa. Zinkawoneka ngati chozizwitsa.
N'zomvetsa chisoni kuti sindinathe kulekerera Lyrica. Zotsatira zoyipa zinagwera mkati ndipo ndinayenera kuyirako pambuyo pa milungu ingapo. Komabe, sindingathe koma ndikudabwa ngati ndamva kusintha komwe ochita kafukufuku adawona, kapena chinachake chofanana ndi iwo.
(Poyankhula za mankhwala, nthawi zonse kumbukirani kuti aliyense wa ife ali ndi mayankho ake apadera kwa iwo komanso kuti zondichitikira zanga zisakhale ngati zanu.
Musaganize kuti mutha kukhala ndi zofanana kapena zolephera ngati wina.)
Dziwani zambiri
- Lyrica kwa Fibromyalgia
- Mankhwala Osokoneza Bongo kwa Fibromyalgia
- Kodi Mitundu ya Fibromyalgia Ndi Yabwino Kwambiri?
Zotsatira:
Kuchinad A, et al. Journal of neurocience. 2007 Apr 11; 27 (15): 4004-7. Kuthamanga kwa ubongo kumatenda kuwonongeka kwa matenda a fibromyalgia odwala: kukalamba msanga kwa ubongo?
Puiu T, et al. Arthritis ndi rheumatology. 2016 Jan 27. Kusinthika kwa mutu wa imvi kumawoneka ndi kuchepetsa kupweteka kosavuta kutsatila motsatira zotsatira zoyipa za pregabalin administration.
Schmidt-Wilcke T, et al. Ululu. 007 Nov; 132 Suppl 1: S109-16. Nkhani yakuda imayamba kuwonjezeka kwa odwala fibromyalgia-kufufuza kwa voxel-based morphometry.
Talati A, Hirsch J. Journal ya chidziwitso cha sayansi. 2005 Jul; 17 (7): 981-93. Kugwiritsidwa ntchito mwachindunji mkati mwa gyrasi yapakati podziwa kuti apite / osapita zisankho zokhudzana ndi "zomwe," "pamene," ndi "komwe" zowonjezereka zowonjezera: kufufuza kwa fMRI.