Kukambirana ndi Dr. Ben Lynch, Wodziwa pa MTHFR Polymorphisms
Kusintha kwa MTHFR - kusintha kwa jini lomwe likugwirizanitsidwa kwambiri ndi matenda osiyanasiyana - kuphatikizapo matenda a chithokomiro - akukhala nkhani yotentha kwambiri komanso yotsutsana. Kuti mudziwe zambiri za ziphunzitso ndi zochitika zokhudzana ndi MTHFR - chomwe chiri chidule cha jini wotchedwa methylenetetrahydrofolate reductase, ndinatembenukira kwa Dr. Ben Lynch, dokotala yemwe ali ndi naturopathic yemwe akuyang'anitsitsa kwambiri MTHFR polymorphisms ndi kusintha kwa majini, ndi kugwirizana kwa matenda ndi zikhalidwe. Dr. Lynch akuthamanga malo, Mthfr.net, omwe aperekedwa ku kafukufuku ndi kuzindikira za MTHFR, ndipo buku lake pa nkhaniyi linafalitsidwa mu 2014.
Funso: Kodi chonde mungafotokoze, kwa omwe sakudziwa kapena sanamvepo, zomwe zimapangitsa kuti polymorphism ya MTHF is?
Dr. Ben Lynch: Jini ya MTHFR imapanga mavitamini otchedwa methylenetetrahydrofolate reductase. Ntchito ya mthemayi ya MTHFR ndiyo kutembenuza mtundu umodzi wa zochitika mumtundu wambiri wogwira ntchito komanso wodalirika mthupi la munthu - mu selo iliyonse. MTHFR imatenga folic acid ndikuisintha kuti thupi ligwiritse ntchito. Folic acid pokhapokha ndi yopanda phindu - imakhala yopanda kanthu - mpaka imatha kupyolera mu michere yambiri mu thupi ndi kusandulika kukhala mitundu yosiyanasiyana yomwe thupi lingagwiritse ntchito - monga methyltetrahydrofolate, kapena kuchepetsedwa monga methylfolate.
Methylfolate ndi gulu lofunika lomwe limapanga ntchito ziwiri zovuta.
Choyamba, methylfolate imathandiza kupanga ubongo wa ubongo mu ubongo wanu. Ovomerezeka ndi omwe amalola ife kulingalira, kugona, kuthawa, kufotokoza maganizo ndi kuphunzira. Pamene magulu a methylfolate ali otsika, chomwechonso ndizomwe mumaziteteza.
Kuchepetsa odwala matendawa kumayambitsa mikhalidwe yoledzera, kupanikizika, nkhawa, ADHD, mania, kukhumudwa, kusowa tulo, vuto la kuphunzira ndi ena.
Awiri, methylfolate amatithandizanso kuti tizipanga mankhwala otchedwa s-adenosylmethionine - otchedwanso SAMe. SAMe ndi yofunika kwambiri chifukwa imathandiza kulamulira maantimenti oposa 200 m'thupi la munthu - izi ndizochepa kwa adenosine triphosphate (ATP), yomwe ndi mphamvu ya magetsi ya thupi.
Popanda ATP, moyo umatha. Popanda SAM, moyo umatha.
Ndi ma SAMe otsika, inu, kapena okondedwa anu, muli pachiopsezo chachikulu cha matenda monga khansa, kusabereka, kutuluka m'mimba, autism, Down syndrome, thrombosis, kuthamanga kwa magazi , mavuto oyankhula ndi zina.
Ndizofala kuti jini la MTHFR lisagwire ntchito komanso liyenera kutero. Chifukwa chiyani? Chifukwa mmodzi mwa anthu awiri ali ndi malo m'thupi la MTHFR yomwe ili ndi DNA yolakwika. Kusintha kwake kwa DNA kumatchedwa polymorphism. Tanthawuzo lotanthauza "ambiri" ndi matanthauzidwe omveka kuti 'mawonekedwe'. Pamene jini la MTHFR liri ndi polymorphism, michere yomwe imapanga ili ndi mawonekedwe osinthika. Maonekedwe osinthika amachepetsa mphamvu yothandizira ya mthemayi ya MTHF. Ntchito yosinthidwa imayambitsa kuchepa kwa ntchito ya neurotransmitter ndikuchepetsa kuchepa kwa SAM.
Funso: Kodi njira ya methylation ndi chiyani?
Dr. Ben Lynch: Tiyeni tiyambe tanthauzo la methylation . Methylation ndikutenga kaboni limodzi ndi atatu hydrogen, omwe ndi methyl gulu, ndipo amadzigwirizanitsa ndi ma enzyme m'thupi lanu. Pamene gulu la methyl limagwirizanitsa ndi enzyme, enzyme imachita kanthu. Chizoloŵezi chochitidwa ndi methylation yomwe mumayamikira tsiku ndi tsiku ndi kuwonongeka kwa mbiri ya histamine.
Gulu la methyl limapangidwa ndi njira ya methylation ndipo imayandama mpaka itapeza chitsimikizo chokhachi kuti chimangirire. Pankhani iyi, gulu la methyl limamangiriza ku histamine. Pamene gulu la methyl likumangiriza ku histamine, histamine imaphwanya ndipo imatha.
Mutha kuzindikira tsopano zomwe zimachitika ngati njira yanu ya methylation siimapanga magulu a methyl okwanira pa nkhaniyi. Histamine yanu siimaphwanyidwa ndipo motero mazenera anu a mbiriyakale akuchulukira, kuchititsa mphuno zanu kuthamanga ndi maso kuti awonongeke.
Kodi ntchito ya SAM ndi iti? Ntchito ya SAMe ndiyo kungotenga zomwe zimatchedwa 'methyl gulu' ndikuzipereka kwa mavitamini oposa 200 m'thupi kuti achite ntchito zosiyanasiyana zofunikira.
Ntchito zina zazikuluzikulu za gulu lotchedwa methyl gulu ndi:
- Tetezani DNA yanu. Izi ndi zofunika kwambiri. Mwachitsanzo, ngati DNA yanu siyitetezedwe, ndiye kuti akhoza kuwonongeka ndi mavairasi, mabakiteriya, zitsulo zamphamvu, solvents ndi ena. Pakapita nthawi, kuwonongeka kumeneku kumakhala kwakukulu ndipo kungayambitse kufalikira kwa maselo. -
- Kuchepetsa mazamu a histamine ! Kubwereza izi zimalowa mkati. Gulu la methyl loperekedwa ndi SAMe limathandiza kuchotsa histamine m'thupi. Anthu omwe ali ndi chifuwa chokhala ndi mitsempha yambiri akhoza kukhala ndi mbiri yapamwamba ya histamine ndi kuchepetsa magulu a methyl. -
- Tengerani chigawo chofunikira pa maselo anu omwe amatchedwa phosphatidylcholine. Gulu la methyl loperekedwa ndi SAMe limathandiza kupanga phosphatidylcholine yomwe imalowa mkati mwa makoma a maselo anu onse, omwe amadziwika kuti maselo. Ngati maselowa amatha kuwonongeka ndi ofooka, maselo amakhala ofooka, alola poizoni ndi zinthu zoipa mu selo, osakhala ndi zakudya zopatsa thanzi ndipo amafa. Kuchuluka kwa maselo a membrane kuwonongeka kungayambitse matenda aakulu monga multiple sclerosis ndi khansa kutchula ochepa.
Funso: Munadziŵa bwanji za MTHFR, ndipo nchiyani chinakulimbikitsani kuti mupange gulu lanu lachinsinsi?
Dr. Ben Lynch: Tsiku lina madzulo, mayi wina anandifunsa za njira zamankhwala zomwe zingasokoneze bipolar matenda. Ndinayamba kuyendetsa njira zonse zachibadwa zolimbitsa anthu omwe ali ndi matenda a maganizo ochititsa munthu kusinthasintha maganizo. Pazifukwa zina, ndinamva kuti yankho langa silinakwaniritsidwe, mwina chifukwa chakuti ndinali nditachoka sukulu ya zachipatala kwa zaka zingapo ndipo ndinkafuna kuona ngati kufufuza kunabweretsa chilichonse chatsopano.
Kotero ine ndinagwira kafukufukuyo ndipo ndinapeza kuti ofufuza anali kufufuza za kusinthasintha maganizo ndi zamoyo, makamaka MTHFR. Sindinadziwe kuti MTHFR inali yotani ndipo ndinalowa mu "MTHFR" ku deta yafukufuku wa zachipatala, PubMed, yomwe ndi deta ya US National Library of Medicine. Ndinadabwa zomwe zinabwerera kwa ine. Mapepala oposa 3,000 panthawiyo. Tsopano ndi mapepala okwana 5,200 pa MTHFR yekha - ndikuwonjezeka.
Pamene ndinkasanthula ma pepala a zofufuzidwa ndi MTHFR mmenemo, ndinadabwa ndi zikhalidwe zingati zomwe zinapezeka. Mankhwala ochotsera odwala , odwala matenda opatsirana kwambiri, thrombosis , schizophrenia, myocardial infarction ( matenda a mtima ), acysiblastic leukemia , kutaya mimba mobwerezabwereza - ndipo izi zinali patsamba 1 !! (Mungathe kudziwonera nokha!)
Ndinadabwa kwambiri kuti sindinamvepo za izi kuti 'tweeted' za MTHFR - ndipo sindinathe konse 'tweet'. Tsiku lotsatira, ndinakankhidwa ndi anthu omwe anali kufunafuna dokotala wodziwa za MTHFR. Mosakayikira, chidziwitso changa sichinali koma ndinalonjeza kuti ndidzaphunzira. Mpaka lero, ndikupitiriza kuphunzira zovuta za MTHFR ndikudutsa nzeru zanga kwa madokotala.
Mapuloteni amtunduwu amapezeka kwambiri ndipo amawononga mamiliyoni ambirimbiri. Komabe, pozindikira, omwe ali ndi ma poymmphisms a MTHFR amatha kuwonjezera moyo wawo wathanzi ngati atadziwa kuti moyo wawo, zakudya zawo komanso zachilengedwe zimachepetsa kwambiri chiopsezo cha matenda.
Funso: Ndi thanzi liti lomwe lingapindule kwambiri pozindikira za MTHFR?
Dr. Ben Lynch: Mwachidule - omwe ali ndi ma genetic polymorphism m'thupi lawo la MTHFR - zomwe zimakumbukira, ndi mmodzi mwa ife. Ngakhale iwo omwe alibe MTHFR polymorphisms amapindula kudziŵa za iwo monga okondedwa awo kapena abwenzi angakhale nawo ndipo ngati adziwa, angakhudze miyoyo yawo mozama.
Izi ziyenera kutchulidwa kuti madokotala ayenera kuzindikira kuti MTHFR ndi yofunika chifukwa ndi omwe amayang'anira thanzi la wodwalayo. Choncho, ndi kwa dokotala kuti adziwe wodwalayo ndi kuwasindikiza ma polymorphisms a MTHFR.
Funso: Ndani ayenera kuyesedwa kwa MTHFR ndi kuti / kodi angayesedwe bwanji?
Dr. Ben Lynch: Aliyense ayenera kuyesedwa. Chifukwa chiyani? Chifukwa chakuti anthu amodzi (1) mwa anthu awiri (2) aliwonse amakhudzidwa ndipo ngati wina akudziwa kuti ali ndi polymorphism ya MTHFR, amadziwa kuti amayenera kukhala otetezeka kwambiri kuti azisamalira okha.
Kuyesera kwa MTHFR kumafunika kuwonedwa ngati kuyesa kuyesera. Ngati wina akufuna kutenga mimba, amayesa MTHFR. Ngati wina akufuna kuchepetsa zizindikiro za matenda omwe ali ndi kachilombo ka HIV ndikuwongolera thanzi lawo, amayesa MTHFR. Ngati wina akufuna kudziwa chifukwa chake banja lawo likuwoneka kuti liri ndi chiopsezo chachikulu cha matenda a mitsempha, matenda a mtima , khansa, kuvutika maganizo kapena autism kutchula ochepa, iwo amayesa MTHFR.
Mukapita kwa dokotala wanu ndikukupempha kuti akuwonetseni MTHFR, zinthu ziwiri zidzachitika. Mmodzi, sakudziwa chomwe chiri ndi ziwiri, adzanena kuti MTHFR si chinthu chachikulu ndipo palibe chodandaula nacho - zonsezi ndi fad.
Mwadzidzidzi mutakhala ndi dokotala wodalirika, wamakono, akuyesani kuti muyambe kuyesa ma polymorphisms. Chenjezo apa.
Makampani ambiri a inshuwalansi samaphimba kuyesa kwa MTHFR ndipo ngati akunena kuti akutero, iwo angabwererenso ndikukulipirani ndalama zambiri.
Izi zinati, pali makampani ena oyesayesa kunja komwe amayesa kuyerekezera mosamalitsa komanso mokwanira ndipo angakhale ataphimbidwa ndi inshuwaransi.
Makampani awiri omwe akutsogolera MTHFR akuyesera ndi Spectracell Labs ndi Lab Lab Test Now.
Ngati mulibe inshuwalansi, simungathe kuwononga ndalama za mthumba, makamaka mutapereka zotsatira zomwe zingasinthe moyo wanu.
Kuti mudziwe zambiri zokhudza mayeso a MTHFR - kuphatikizapo mfundo zamakhalidwe abwino - phunzirani zambiri pa siteti ya MTHFR.
Funso: Kodi malingaliro anu apamwamba kwa anthu omwe ali ndi ma polymorphisms a MTHF ndi ati?
Dr. Ben Lynch: MTHFR polymorphisms yakhala ikuzungulira kwa mibadwomibadwo ndi mibadwo - ndipo ikufalikira mofulumira kwambiri chifukwa cha folic acid supplementation. )
Ndimakhulupirira kuti zosankha zabwino pa chakudya, malo osasamala, moyo wachangu, ogwirizanitsa ntchito ndi mankhwala opatsirana pogwiritsa ntchito mankhwala amachititsa kuti MTHFR ikhale ndi mapuloteni.
Izi zati, ndizofunikira kwambiri kuti anthu asatulukemo ndipo amasiya kumvetsera malonda osokoneza bongo pa TV akuyesa 'Funsani dokotala ngati mankhwalawa ndi abwino kwa inu.' Ndikutha kukuuzani pakalipano, ayi.
Malangizo apamwamba mu mawonekedwe a zipolopolo - ndikudziwitsani kuti ndimatsatira zomwe ndikulalikira - ndi awa:
- Idyani lonse, organic, osati GMO, ufulu wautali, zakudya zakutchire.
- Lekani kuyika zowonjezera mavitamini a folic acid ndi folic acid opindulitsa zakudya. Gwiritsani ntchito zinthu zachilengedwe monga folinic acid ndi / kapena methylfolate.
- Idyani zakudya zomwe zili ndi zinthu zachilengedwe monga masamba omwe samasamba. (Inde - muyenera kudya saladi tsiku ndi tsiku.)
- Imwani madzi opopera otchinga - onetsetsani madzi omwe ali ndi pulasitiki mu pulasitiki omwe ali ndi bisphenol A (BPA).
- Pewani zakudya zam'madzi ndi mkaka.
- Kulepheretsa kuwonetsa mankhwala m'thupi (ie formaldehyde mu zovala zatsopano, ma carpets, mipando ndi zomangamanga zatsopano, ndi ozimitsa moto mu zovala, mabedi, mipando, ma carpets).
- Kupuma bwino kwa mimba.
- Maganizo abwino.
- Kuseka.
- Tulukani mu chilengedwe. Ndife, pambuyo pake, zinyama. Musaiwale zimenezo. Tikusowa zochitika zachilengedwe.
- Kondani ntchito yanu - ngati simukukonda, sintha.
- Ubale - ukwati wokondwa kapena ubale wabwino,
- Banja - kambiranani ndi okondedwa anu ndipo muzisangalala nazo.
- Amzanga - gawani ndikuchita nawo ntchito.
- Tengani maulendo.
- Kuchita masewera olimbitsa thupi - kosangalatsa - osati mopitirira muyeso. Kambani nawo masewera a timu, makampu.
- Sauna.
- Limbani gulu lachipatala lokhala patsogolo, kutsogolera kuganiza za MD, NDs, DO ndi ena azaumoyo.
Funso: Kodi pali kugwirizana pakati pa thanzi labwino ndi MTHFR?
Dr. Ben Lynch: Inde alipo. Tonsefe tikudziwa kuti hypothyroidism yochuluka bwanji .
Ngati wina ali hypothyroid, kutanthauza kuti chithokomiro chawo chikugwira ntchito pang'onopang'ono, ndiye kuti munthuyo adzakhala ndi luso lopweteka la MTHFR komanso - ngakhale munthuyu alibe mankhwala a MTHFR polymorphism.
Chifukwa chiyani?
Chifukwa chithokomiro chimapanga chimene chimatchedwa T4, chomwe chimatchedwanso thyroxine . Thyroxine imathandiza kupanga vitamini B2, thupi la flavin adenine dinucleotide (FAD).
Vitamini B2 iyenera kusandulika kukhala FAD yogwira ntchito ndi thyroxine kuti thupi lizitha kugwiritsa ntchito bwino vitamini B2.
Kulumikizana pakati pa FAD ndi MTHFR ndikuti mazira a MTHFR ayenera kukhala ndi chakudya chokwanira cha FAD kuti agwire ntchito. Ngati miyendo ya FAD ndi yochepa chifukwa cha kuchepa kwa thyroxine, ndiye kuti mapuloteni a MTHFR amachepetsanso, zomwe zimapangitsa kuti ma methylfolate akhale otsika. Tsopano tikudziwa kuchokera pamwamba kuti mankhwala otsika a methylfolate amapititsa otsika kwambiri m'mimba komanso otsika SAMe.
Funso: Kodi odwala hypothyroid angachite chiyani, mwachitsanzo, zakudya zopatsa thanzi komanso kusintha kwa moyo, kuti athe kulimbana ndi matendawa?
Dr. Ben Lynch: Odwala a hyperothyroid ayenera kuti adokotala awone mawonekedwe awo a TSH, T4, T3, ndi tizilombo toyambitsa matenda nthawi zambiri kuti athandize chithokomiro . Ngati imodzi mwazimenezo sizichotsedwa, ndiye kuti chithokomiro chidzasokonezeka ndipo motero chinyontho cha MTHFR chidzakhala chimodzimodzi.
Ndikofunika kwambiri kuti madokotala aziwunika zonsezi ndi osati TSH . Kuyeza kwa TSH palokha kulibechabechabe. Zili ngati wina wakufunsani kumene makiyi amachokera ndipo mumayankha mmbuyo, "Kumeneko." 'Kumeneko?' mufunsanso. Iwo amayankhira mmbuyo, "Kumtunda uko." Zosathandiza kwenikweni kupatula ngati munthuyo akuwonekeratu kuti 'pali' kapena kukufotokozerani bwinoko.
Zakudya zofunika kwambiri pa chithokomiro ndi magnesium, ayodini, selenium, zinki ndi tyrosine - zomwe zimachokera ku kudya - ndikudya - mapuloteni okwanira.
Methylfolate, yopangidwa ndi mthemayi ya MTHFR, ikufunikanso kuthandiza kutembenuza tyrosine kukhala mankhwala otentha a chithokomiro.
Kusintha kwa moyo wanu kuti muyambe kutulutsa chithokomiro kungakhale kuchepetsa chlorine, bromine (bromide), ndi fluoride - makamaka ma halo ena. Chifukwa chiyani? Chifukwa chakuti ziwalo zinazi zimatsanzira mazira a halogen, ndipo izo zimalepheretsa ayodini kuti asamangidwe kwa khungu lanu la chithokomiro.
Ngati muli ndi ziwalo zina pa chithokomiro chanu, kodi ayodini imayenera kukhala yani? Zovuta - makamaka ngati imodzi ndi yowonjezeka ya ayodini ndipo amayi ena a ku America alibe vuto la ayodini .
Lankhulani ndi dokotala wanu za momwe mungayang'anire mayendedwe a ayodini ndi kuwonjezera bwino ngati pakufunikira.
Ndikupangira kukhazikitsa mafayironi otentha a chlorine osamba, kusuta madzi anu akumwa, kuchepetsa kutuluka kwa fluoride, ndi kuchepetsa kapena kupewa kumwa soda, monga mankhwala ambiri a citrus ali ndi mafuta a masamba a brominated.
Kusintha kwa chilengedwe kuteteza chithokomiro chanu kungakhale kupeŵa zitsulo zolemera monga mercury. Mercury ndi zitsulo zina zolemera ndizoopsa kwambiri kwa chithokomiro. Mercury amalgams amafufuzidwa kuti akhale chinthu choopsa chochititsa matenda a Hashimoto.
Chakudya chofala chomwe chimakhudza kansholo yanu ndi gluten. Kutulutsa gluten kwathunthu ku zakudya zanu kungakuthandizeni kwambiri kuti mukhale ndi chithokomiro . Izi zikutanthauza kutetezedwa 100% - osati kusanganiza kamodzi pa sabata kapena kamodzi pa mwezi - kupeŵa kwathunthu. Izi ndi zofunika kwambiri ngati muli ndi matenda a celiac.
Funso: Kodi mungatiuze za webusaiti yanu ya MTHFR.net?
Dr. Ben Lynch: Ndimachita homuweki. Ngati ndikanena chinachake, ndikupenda kufufuza kapena ine ndikufotokoza momveka bwino kuti ndi chiphunzitso chogwira ntchito. Sindikudziyerekezera kuti ndikudziwa chinachake chimene sindikuchita. Ngati sindikudziwa kanthu, sindikulemba kapena kupanga yankho, ndimangonena mawu atatu - "Sindikudziwa."
Ngati anthu angayime ndi kumvetsa kuti "Sindikudziwa" ndi zabwino komanso zothandiza, ndiye mankhwala ndi madera ena a moyo adzakhala bwino kwambiri.
Ndimawerenga nthawi zonse - ndikufufuza mozama - mapepala ofufuzira pa MTHFR, methylation, nutrigenomics, imodzi ya carbon diabetes, ntchito ya mitochondrial ndi epigenetics. Ndimakonda zomwe ndikuchita ndipo ndimakhudzidwa kwambiri ndikukhudzidwa nazo. Chifukwa chiyani? Chifukwa ndikudziwa kuti izi zidzasintha momwe mankhwala amachitira.
Njira yachipatala lero ndi yomwe imayenera kugwedezeka pazenera. Chizindikiro-matenda otengera chitsanzo ndi operewera kwambiri ndipo madokotala amadziwa izi. Iwo akutembenukira ku mankhwala osokoneza bongo ndi othandiza. Vuto ndi madotolowa omwe akupitiriza kuchita chidziwitso chomwecho-matenda ochigwiritsa ntchito pogwiritsira ntchito zowonjezeretsa, zitsamba ndi zina zina m'malo mwa mankhwala ndi opaleshoni. Inde, izi ndizowonjezera nthawi zambiri koma sizikulimbana ndi chifukwa chachikulu chomwe chimachititsa kuti wodwalayo adwale.
Ndikuphunzitsa madokotala ena za mtundu watsopano umene ukuchokera kuzinthu zonsezi komanso kuti ndi zakudya zam'madzi. Dokotala akamaganizira za moyo wa wodwala, zakudya, zozungulira, zosangalatsa, maganizo, chilengedwe, majini, ndi majini, ndiye zinthu zodabwitsa zimachitika. Ingokufunsani madokotala amene adapezekapo ku misonkhano yanga. Kuphunzirira kumakhala kovuta komanso kosautsa, koma kopindulitsa kwambiri chifukwa mutaphunzira, mumapitiriza kuchita bwino ndipo odwala anu amathamanga mofulumira komanso mofulumira.
Palibe chabwino kwa dokotala ndiye kuti ayenera kuika chizindikiro pa khomo lakumaso - "Odwala amafunikira. Ena onse anga ndi abwino. "
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Dr. Ben Lynch ndi dokotala wotchedwa naturopathic yemwe wagwiritsa ntchito kafukufuku wake ndi kuphunzitsa pa MTHFR polymorphisms ndi kusintha kwa majini, ndi kugwirizana kwa matenda. Webusaiti ya Dr. Lynch ya http://mthfr.net ili ndi kafukufuku, nkhani, mauthenga ndi mauthenga okhudzana ndi kusintha kwa chibadwa cha MTHFR ndi ma polymorphisms. Bukhu lake pa mutu uwu lidzapezeka nthawi ya masika a 2014 pa webusaitiyi, ndi malo ogulitsira malonda. Mutha kupeza Dr. Lynch pa Facebook.