Kufufuza Umboni Pothandiza Kuteteza
Intravenous immunoglobulin (IVIG) ndi mtundu wa mankhwala omwe amachititsa kuti thupi limatetezedwe m'thupi. Ma antibodies ndi mapuloteni oteteza thupi lomwe limatulutsa matenda.
IVIG imakhulupirira kuti imagwira ntchito m'maganizo a ubongo chifukwa cholimbikitsa ziwalo zina za chitetezo cha mthupi komanso kupondereza ena.
Palibe amene akudziwa bwino lomwe momwe zimagwirira ntchito, ndipo, motero, IVIG imatchulidwira kunja-chizindikiro (popanda chidziwitso cha FDA) kwa matenda omwe chitetezo cha mthupi cha munthu chimatayika kwambiri.
Izi zikhoza kuphatikizapo seonis, ma ARV, ndi zina za HIV . Amagwiritsidwanso ntchito ngati chithandizo cham'chigawo chachiwiri kuchipatala pobwezeretsanso-remitting multiple sclerosis (RRMS) .
Zochita za IVIG mu Multiple Sclerosis
IVIG imagwiritsidwa ntchito mu multiple sclerosis (MS) kuti pang'onopang'ono matendawa apitirire komanso kuchepetsa kufooka kumene kumayambitsa matendawa. Ngakhale kuti palibe mgwirizano woonekeratu wa momwe IVIG ilili yoyenera, yasonyeza malonjezano kumadera osiyanasiyana:
- Kulepheretsa kubwezeretsa kachilombo ka HIV mimba yobereka
- Kuwathandiza anthu omwe alephera kulandira mankhwala oyamba a RRMS ndipo sangathe kulekerera mankhwala osokoneza bongo
- Kuchiza MS njira yachiwiri yopita patsogolo (ngakhale pali kutsutsanako za momwe izo zimagwirira ntchito)
Kafukufuku wina adanenanso kuti IVIG yoperekedwa pa nthawi yoyamba ya matenda a ubongo wa MS (yotchedwa matenda okhaokha, kapena CIS ) ingachepetse mwayi wa munthu kuti atembenuzidwe bwinobwino ndi MS. Zambiri mwa kufufuza kumeneku zakumananso ndi kusakayikira kapena kukayikira.
Mphamvu ya IVIG
Panthawiyi, palibe amene amadziwa momwe HIV imathandizira pakuthandizira kapena kuchepetseratu zotsatira za MS.
Umboni wambiri wakhala wokhudzana ndi zotsatira za matenda ena a ubongo, monga Guillain-Barré matenda ndi myasthenia gravi s. Zofukufuku zinangoyang'ana pa IVIG ndi MS zakhala zosakanikirana bwino.
Kafukufuku wina wa ku Australia adasonyezera kusintha kwakukulu koma kodasintha kwambiri kulemala monga kuyerekezedwa ndi kukula kwa chilema cha EDD) . Ena asintha pang'ono pang'ono kukula kapena nambala ya zilonda za ubongo pa MRI.
Ena, panthawiyi, sanasonyeze kusiyana kwa mphamvu ya IVIG poyerekeza ndi maloboti pochiza RRMS.
Mwina mbali imodzi ya lonjezano ndiyo kugwiritsa ntchito IVIG pokhapokha atabala, zomwe zasonyeza kuti kuchepetsa kuchepetsa kubwerera kwa amayi atsopano.
Mlingo ndi Utsogoleri
Ngakhale kuti mlingo wa mlingo wa mlingo wa mlingo ndi mlingo wafupipafupi sunakhazikitsidwe kwa RRMS, olemba ambiri amalangiza mlingo wa gramu imodzi pa kilogalamu ya kulemera kwa thupi kamodzi pamwezi. Ena amapereka njira ya 400 mg / makilogalamu pa tsiku masiku asanu.
Zotsatira Zotsatira
Zotsatira zofala kwambiri za IVIG ndizopweteka mutu (zomwe kawirikawiri zimachitiridwa ndi chifuwa chachikulu chotchedwa Tylenol). Zina mwa zotsatira zake zimaphatikizapo malungo, kupweteka pamodzi, kupweteka pachifuwa, ndi kusanza. Kawirikawiri, kutupa kwa mankhwala osokoneza bongo kungayambe.
Zoopsa zina zosavuta koma zosawerengeka zakhala zikudziwika, kuphatikizapo aseptic meningitis , matenda a mtima, kupwetekedwa, mitsempha yambiri ya mitsempha, kupweteka kwa impso, ndi kupunduka kwa impso.
Kuyanjanitsa ndi Kutsutsana
IVIG sayenera kugwiritsidwa ntchito kwa anthu omwe ali ndi vuto la impso kapena kusowa kwa IgA (matenda omwe amachititsa kuti munthu asatenge kachilombo kamene kamateteza matenda opatsirana pakamwa, pamtunda, ndi m'mimba). A
Pakalipano, IVIG iyenera kugwiritsidwa ntchito mosamala kwa anthu omwe ali ndi:
- Matenda a mtima
- Matenda a shuga
- Kusamalitsa kwa immunoglobulins
- Kusamalitsa kwa maltose kapena sucrose (zosakaniza zomwe zimagwiritsidwa ntchito m'mawu ena a IVIG)
Njira yokhayo yodziwika bwino ndi IVIG imaphatikizapo katemera wamoyo. Mankhwala a Immunoglobulins angathe kupereka katemera popanda ntchito komanso chitetezo chilichonse chomwe katemera angakwanitse.
Mtengo wa Chithandizo
IVIG yakhala yotsika mtengo kwambiri pa $ 100 pa gramu. Kwa munthu wolemera makilogalamu 70, mlingo womwe umalimbikitsidwa mwezi uliwonse ukhoza kumalipira ndalama zokwana madola 7,000 pa kulowetsedwa, osaphatikizapo ndalama zothandizira ndi kuyamwitsa.
Makampani ena a inshuwalansi angapange ndalamazo, koma nthawi zambiri zimakhala zovuta kuwalimbikitsa kuchipatala ndipo kawirikawiri zimafuna njira yothandizira kuti pakhale chivomerezo. Ngati atavomerezedwa, ndalama za inshuwaransi zingakhale zapamwamba kwambiri. Komabe, opanga ena a IVIG amapereka mapulogalamu othandizira odwala (PAPs ) kuti asamalire kapena kutseka mtengo wa mankhwala.
Mawu Ochokera
Ngati IVIG ikulimbikitsidwa, mungafunikire kudzidandaulira nokha kuti muvomereze ndi inshuwalansi yanu. Pomwe zikunenedwa, ndizofunika kumvetsetsa ubwino ndi zoperewera za chithandizochi - makamaka chomwe kafukufukuyo akutiuza ndipo satiuza.
Ngati simukudziwa bwino izi, musazengereze kufunafuna lingaliro lachiwiri kuchokera kwa katswiri wodziwa bwino.
> Zotsatira:
> Bayry, J ;; Hartung, H ;; ndi Kaveri, S. "IVIg pa kubwezeretsa-kutsekula m'mimba zambiri: malonjezo ndi kusatsimikizika." Miyambo ya Pharm Sci. 2015; 36 (7): 419-421.
> Gilardin, L .; Bayry, R .; ndi Kaveri, S. "Kutenga immunoglobulin monga chithandizo chamankhwala chamagetsi." CMAJ. 2015; 187 (4): 257-264.