Kusuta ndi kunenepa kwambiri kumapangitsa kulemera kwa kutupa
Nthawi zina anthu amaganiza kuti nyamakazi ya nyamakazi ndi osteoarthritis ndizofanana. Ngakhale mafupa a osteoarthritis amayamba chifukwa chogwiritsidwa ntchito kwa nthawi yaitali, nyamakazi ya nyamakazi imakhala matenda ovuta komanso ovuta kwambiri omwe chitetezo cha mthupi chimagonjetsa maselo ndi ziphuphu zake, kuphatikizapo ziwalo, khungu, ndi zina. ziwalo.
Mofanana ndi matenda ena, monga lupus ndi psoriasis, chomwe chimayambitsa matenda a nyamakazi sichimveka bwino.
Chimene tikudziwa ndi chakuti zinthu zina-kuphatikizapo kusuta ndi kunenepa kwambiri-zingakupangitseni kuti mukhale ndi chiopsezo chachikulu chothetsera matendawa komanso kukhala ndi zizindikiro zoopsa.
Zina mwazifukwa zomwe zimayambitsa matenda a nyamakazi zimasinthika (kutanthauza kuti tingazisinthe), pamene zina zosasinthika ndi malo omwe ali pangozi.
Zosasinthika Zosasinthika
Matenda a nyamakazi amawakhudza magulu ena kuposa ena. Zinthu zitatu zosasinthika zomwe zimagwirizanitsidwa ndi matendawa ndi zaka, chibadwidwe, komanso mbiri ya banja ya nyamakazi.
Zaka
Ngakhale nyamakazi ya nyamakazi ingagwire pa msinkhu uliwonse, kuyamba kwa zizindikiro kawirikawiri kumayambira pakati pa zaka 40 ndi 60. Komanso, chiopsezo chidzakulira okalamba omwe mumakula. Zowonjezera, vuto la nyamakazi ya nyamakazi lidzawonjezeka katatu pakati pa zaka 35 ndi 75, ndikuwonjezeka kuyambira 29 pa anthu 100,000 kufika pa 99 pa 100,000, malinga ndi kafukufuku wochokera ku Mayo Clinic.
Gender
Azimayi nthawi zambiri amakhala ndi nyamakazi kusiyana ndi amuna. Ngakhale kuti kufotokoza kwa kusamvetseka uku sikungatheke, mahomoni amakhulupirira kuti ali ndi gawo lalikulu.
Izi zikuwonekera mwa mbali mwa kafukufuku amene wasonyeza kuti amayi nthawi zambiri amakhala ndi matendawa pambuyo pa kusintha kwakukulu mu mahomoni awo.
Izi nthawi zina zimachitika pokhapokha atatenga mimba kapena poyambira ndi kuyamba kwa kusamba. Estrogen , kapena makamaka kutayika kwa estrogen, amakhulupirira kuti ndi amene amachititsa.
Koma mbali yowonjezera isrogen ikhoza kupereka chitetezo kwa amayi achikulire amene angakhale osatetezeka ku matendawa.
Phindu lomwelo lingaperekedwe kwa atsikana achichepere amene amatenga phokoso lachinsinsi (aka "mapiritsi"). Malinga ndi ofufuza a Karolinska Institute ku Stockholm, amayi omwe agwiritsira ntchito njira za kulera za estrogen kwa zaka zoposa zisanu ndi ziwiri, anapeza kuti pafupifupi 20 peresenti inachepetsa chiopsezo cha matenda a nyamakazi poyerekezera ndi amayi omwe sanayambe kumwa mapiritsi.
Genetics
Ngati muli ndi kholo kapena m'bale wanu ali ndi matenda a nyamakazi, chiopsezo chanu chokhala ndi matendawa chikuposa katatu kuposa chiwerengero cha anthu. Zachiwiri-zachibale zimakhala zocheperapo kaŵirikaŵiri. Zithunzizi zimathandiza kufotokoza mbali yaikulu yomwe ma genetic amachitira pa chitukuko cha matendawa .
Malinga ndi kafukufuku wa 2017 wofalitsidwa mu The Lancet, maina a chibadwa amathandiza pakati pa 40 peresenti ndi 65 peresenti ya milandu yonse yotsimikiziridwa. Ngakhale kuti zenizeni zenizeni zamoyo sizidziwikiratu, anthu omwe ali ndi matenda oponderezedwa amadzimadzi amakhulupirira kuti ali ndi kusintha kosintha komwe kumasintha njira yomwe chitetezo cha mthupi chimadziwira komanso chimapangitsa anthu omwe akudwala matendawa.
Mmene thupi limatetezera, chitetezo cha mthupi chimatulutsa maselo ake kuchokera kwa anthu othawa kwawo. Ndi matenda a nyamakazi ndi zovuta zina zomwe zimayambitsa matenda, zizindikiro zina za HLA zimatha kutumiza mauthenga olakwika ku chitetezo cha mthupi, kuwuza kuti iwononge maselo ake ndi matenda. Chimodzi mwa zosinthika zomwe zimagwirizanitsidwa ndi izi ndi HLA-DR4 .
HLA-DR4 imagwirizananso ndi matenda ena, monga lupus , polymyalgia rheumatica , ndi matenda a chiwindi. Zina zimapangidwanso kuti zimasintha.
Zochitika Zowopsa Kwamoyo
Zomwe zimachititsa kuti moyo ukhale woopsa ndizo zosinthika. Kusintha zinthu izi sikungowonjezera kuopsa kwa matenda anu, mwina kungachepetse chiopsezo kuti matendawa ayambe kutero. Kusuta ndi kunenepa kwambiri ndi zinthu ziwiri zofunikira kwambiri.
Kusuta
Kusuta kuli ndi mgwirizano-ndi-zotsatira ndi nyamakazi ya nyamakazi. Ndudu sizingowonjezera chiopsezo chotenga matendawa, zimatha kupititsa patsogolo zizindikiro zanu, nthawi zina.
Kafukufuku wambiri wa kafukufuku wopangidwa ndi ochita kafukufuku ku Sunivesite ya Kobe University of Graduate School of Medicine anapeza kuti kukhala wosuta kwambiri (kutanthauza kuti kusuta phukusi la ndudu kwa zaka zoposa 20) kumawonjezeranso kaŵirikaŵiri chiopsezo cha nyamakazi. Amuna amakhala okhudzidwa kwambiri kawiri kuposa amayi ndipo nthawi zambiri amakhala ndi zizindikiro zoopsa kwambiri.
Komanso, anthu osuta fodya amene amawoneka kuti ali ndi kachilombo ka HIV (RF) amakhala ndi mwayi wambiri wopeza nyamakazi kusiyana ndi awo osasuta, kaya alipo kapena akusuta fodya. Chifukwa chodzipangira okha, kusuta fodya kumadziwika kuti kulimbikitsa imfa, kuwonjezereka, ndipo kumapangitsa kuti anthu azikhala ndi ufulu wochita zinthu zomwe zingawononge minofu yomwe yayamba kale.
Ngakhale mutakhala ndi mankhwala ochizira matendawa, kusuta kungasokoneze ntchito yawo ndikuwapangitsa kukhala opanda mphamvu. Izi zikuphatikizapo mankhwala oyambira monga methotrexate ndi atsopano TNF-blockers monga Enbrel (etanercept) ndi Huma (adalimumab) .
Kunenepa kwambiri
Matenda a nyamakazi amadziwika ndi kutupa kosatha komwe kumachepetsa ndi kuwononga minofu ndi mafupa. Chilichonse chomwe chimapangitsa kutupa uku kumangopangitsa zinthu kukhala zovuta.
Kunenepa kwambiri ndi chikhalidwe chimodzi chotere chimene chingayambitse kutupa, chifukwa cha kusungunuka kwa maselo a mafuta (adipose) ndi kuchulukitsa kwa mapuloteni otupa otchedwa cytokines . Ma cell adipose kwambiri omwe muli nawo m'thupi lanu, amatha kukhala ndi ma cytokines.
Choncho, n'zosadabwitsa kuti anthu olemera kwambiri amatha kuwonongeka mofulumira kwa mapepala awo poyerekeza ndi anthu omwe ali ndi kulemera kwabwino komanso amakhala ndi mavuto ambiri okhudza matenda, kuphatikizapo pericarditis (kutupa kwa membrane ya mtima), pleuritis (kutupa kwa chipinda cha mapapu), ndi vasculitis (kutupa kwa mitsempha ya magazi).
Komanso, kuwonjezeka kwa thupi sizingathandize koma kuwonjezera kupsinjika kwa ziwalo zomwe zakhudzidwa, makamaka za mawondo, chiuno, ndi mapazi, zomwe zimapangitsa kuti anthu ambiri asathenso kuyenda komanso kupweteka.
Kunenepa kwambiri kungakuchititseni kukupatsani mphamvu zothetsera vutoli, vuto la matenda otsika omwe kutupa kumakhala kochepa. Malingana ndi kafukufuku wochokera ku Weill Cornell Medical College, anthu omwe ali ndi chiwerengero cha mthupi (BMI) oposa 30-kutanthauzira kwa thupi la kunenepa kwambiri-ndi ofooka 47 peresenti ngati kuti apindule poyerekeza ndi anthu omwe ali ndi BMI pansi pa 25.
Kupsinjika Maganizo ndi Zamtima
Ngakhale kuti zizindikiro za nyamakazi zimakhala zovuta chifukwa palibe chifukwa chomveka, pali zinthu zomwe zingayambitse zizindikiro zadzidzidzi.
Kugonjetsa thupi ndi chimodzi mwa izi. Ngakhale kuti njirayi siimvetsetseka, zimakhulupirira kuti kutuluka mwadzidzidzi kwa ma hormoni opanikizika, monga cortisol ndi adrenaline, kungakhale ndi kugogoda kumene kumawonjezera yankho lokhalokha. Ngakhale kuti izi sizikuphatikizapo phindu lalikulu la kuchita masewero olimbitsa thupi, zimasonyeza kuti zochitika zolimbitsa thupi ziyenera kukhala zoyenera, makamaka ngati ziwalozo zikukhudzidwa.
Mmene thupi limayankhira kupsinjika maganizo kumagwirizanitsidwa ndi momwe akuyankhira m'maganizo. Ngakhale asayansi asanapeze mgwirizano woonekera pakati pa zipsinjo ndi matenda a nyamakazi ya nyamakazi , anthu omwe amadwala matendawa nthawi zambiri amawauza kuti nthawi yomweyo amayamba kuda nkhaŵa, kuvutika maganizo, kapena kutopa.
Zina zomwe zimayambitsa matendawa ndi matenda, kuphatikizapo chimfine kapena chimfine, zomwe zimakhudzana ndi kutsegulira mthupi. Kuwombera kumatha kukhalanso chifukwa cha zakudya zina zomwe mumadya, zomwe zimakhulupirira kuti zimagwirizanitsidwa ndi zomwe zimachitika kuti chitetezo cha mthupi chitengeke mosavuta.
Zonsezi zimapangitsa kuti thupi likhale ndi nkhawa zambiri, nthawi zina zimakhala zovuta.
Zotsatira:
> Alpizar-Rodriquez, D .; Pluchino, N .; Canny, G. et al. "Udindo wa mahomoni azimayi pakukula kwa nyamakazi ya nyamakazi." Rheumatology. 2017; 56 (8): 1254-63. DOI: 10.1093 / rheumatology / kew318.
> Doran, M ;; Pond, G ;; Crowson, C. et al. "Zotsatira za chiŵerengero ndi kufa kwa matenda a nyamakazi ku Rochester, Minnesota, kwa zaka zoposa 40." Arthritis Rheum. 2002; 46: 625-3. DOI: 10.1002 / art.509.
> Orellana, C; Saevarsdottir, S .; Klareskog, L. et al. "Mimba zapakhomo, kuyamwitsa komanso chiopsezo cha matenda a nyamakazi: zotsatira za maphunziro a EIRA a Sweden." Annal Rheumatic Dis. 2017; 76: 1845-52. DOI: 10.1136 / annrheumdis-2017-211620.
> Schulman, E ;; Bartlett, S .; Schieir, O. et al. "Kunenepa kwambiri ndi kunenepa kwambiri kumachepetsera mwayi wokhala ndi chikhululukiro chokwanira m'matenda oyambirira a nyamakazi. Nyamakazi: Zotsatira za Phunziro la Mgulu la Amayi a Atsikana a ku Canada . 2017. DOI: 10.1002 / acr.23457.
> Sugiyama, D .; Nishimura, K .; Tamaki, K. et al. "Zotsatira za kusuta zimayambitsa matenda a nyamakazi: nyota yofufuza zofufuza. " Annals Rheum Dis. 2010; 69 (1): 70-81. DOI: 10.1136 / ard.2008.096487.