Momwe zakudyazo zimathandizira Berberine imapereka chiyembekezo kwa amayi omwe akudwala PCOS.
Berberine ndi mankhwala enaake akale amene akhala akugwiritsidwa ntchito ku China kwa zaka masauzande monga mankhwala a shuga, kutsegula m'mimba, ndi kusabereka. Tsopano kafukufuku akuyamba kufufuza ntchito yake kwa amayi omwe ali ndi matenda a polycystic ovary ( PCOS ) mpaka pano, zotsatira zimalimbikitsa kwambiri.
Kodi Berberine N'chiyani?
Berberine ndi alkaloid yomwe imachokera ku zitsamba zachi China monga hydrastis cacadensis (goldenseal), berberis aquifolium (oregon mphesa), berberis vulgaris (barberry), berberis aristata (mtengo turmeric), ndi coptidis rhizome (huanglian).
Zingatengedwe monga kapsule kapena mawonekedwe a madzi.
Kutenga berberine kwasonyezedwa kuti kuthandizire pokonza mikhalidwe yambiri, ndi zotsatira monga zotsatirazi:
- Amapangitsa kuti magazi asatetezeke
- Testosterone yochepa
- Amachepetsa acne
- Mafuta a cholesterol otsika
- Kupititsa patsogolo uchimo wosakhala wothira mafuta
- Kuwonjezera mimba ndi kubala
- Amapereka chithandizo cham'thupi
- Amapereka zotsutsana ndi ma microbial
- Kutsika kwa magazi
- Zothandizira kulemera ndi kuwonongeka kwa thupi
- Kuthana ndi khansa
Berberine ndi PCOS
Berberine ikhoza kupereka madalitso ochuluka kwa amayi omwe ali ndi PCOS kuphatikizapo kulimbikitsa chonde, kuthandizira kulemera kwake, ndi kuchepetsa chiopsezo cha matenda opatsirana omwe amayambitsidwa ndi matenda monga shuga la mtundu wa 2, mkulu wa cholesterol, komanso matenda a chiwindi.
Sensitizer Yopatsa Mphamvu
Mwinamwake udindo wa Berberine waukulu ndi mphamvu yowonjezera insulini. Azimayi omwe ali ndi PCOS awonetsedwa kuti ali ndi maulendo apamwamba a insulini poyerekeza ndi amayi omwe ali ndi zofanana zofanana popanda chikhalidwe.
Metformin ndi mankhwala othandiza kuchepetsa shuga omwe nthawi zambiri amauzidwa kwa amayi omwe ali ndi PCOS kuti athe kuthandizira kusunga insulini ndi ma shuga. Komabe, amayi ambiri omwe ali ndi PCOS amakhala ndi zotsatira za m'mimba za metformin monga kutsegula m'mimba, kusunthira, ndi kupweteka m'mimba. Kugwiritsiridwa ntchito kwa metformin kwa nthawi yaitali kwawonetsanso kuti kumakhudza kutaya kwa vitamini B12 .
Berberine wasonyezedwa kuti ayambe kuchepetsa kutsegula kwa insulini mofananamo ndi metformin. Berberine imapangitsa kuti thupi likhale lopatsirana pogwiritsa ntchito mankhwala a shuga chifukwa chokhazikitsa njira ya protein kinase yokonzedwa ndi AMP.
Madalitso a berberine akhala akufanizidwa ndi metformin mwa amayi omwe ali ndi PCOS. Pa kafukufuku wofalitsidwa mu European Journal of Endocrinology , Wei ndi anzathu adasankha mwadzidzidzi amayi 89 ndi PCOS kulandira kapena berberine (500 mg katatu patsiku), metformin (500 mg katatu patsiku), kapena placebo kwa 3 miyezi.
Amayi onse adalangizidwa ndi odwala zakudya kuti athe kuchepetsa kudya ndi mafuta. Mtundu wa kalori sunaperekedwe. Akazi analangizidwanso kuti azichita masewera 30 tsiku lililonse ndi kuchita masewera olimbitsa thupi.
Patatha miyezi itatu, amayi omwe ali ndi PCOS omwe adatenga berberine adapeza kuchepa kwakukulu kwa kuwonongeka kwa thupi kusiyana ndi metformin kapena placebo. Berberine anatsitsa insulini ndi shuga m'magazi mofananamo ndi metformin.
Azimayi okhala ndi PCOS amene anatenga berberine anaona kuchepa kwa mafuta m'thupi lonse , LDL (ma cholesterol oipa), ndi triglycerides komanso kusintha kwakukulu kwa HDL (ma cholesterol wabwino), kusiyana ndi kutenga metformin kapena placebo.
Kuwonjezera pamenepo, kutenga berberine kutsika pansi ma testosterone onse mofanana ndi a metformin.
Kupititsa patsogolo Chonde
Ngakhale berberine ikuwonetsa phindu pokonza mavuto a kagayidwe ka maselo a PCOS, zingathenso kukonzanso chonde . Phunziro la oyendetsa ndege, amayi 98 opusa ndi PCOS anapatsidwa berberine. Kuchotsa mimba kumawonjezeka ndi pafupifupi 25 peresenti patatha miyezi inayi kutenga berberine.
Kafukufuku amene anafalitsidwa ku Clinical Endocrinology anasonyeza kuti akazi omwe ali ndi PCOS omwe amasankhidwa mwachangu kuti atenge berberine, anali ndi mimba yochulukirapo kusiyana ndi metformin kapena placebo ndipo ndi zotsatira zochepa pamene amatengedwa masabata 12 asanayambe kumwa mankhwala a IVF.
Kuwathandiza Ndi Kutaya Kwambiri
Pafupifupi amayi omwe ali ndi PCOS angakuuzeni kuti kutaya thupi n'kovuta kwa iwo omwe ali ndi vutoli. Ndipo kulemera kwake kumakhala kovuta pa zifukwa zambiri kuphatikizapo kuwonjezereka kwa insulini kukana, zikhumbo zolimba za chakudya, ndi kufooka kwa chilakolako cha kudya.
Berberine angapereke chiyembekezo kwa amayi omwe ali ndi PCOS omwe amavutika ndi kulemera kwawo. Berberine yasonyezedwa kuti kuchepetsa kutsekemera kwa chilakolako chothandiza hormone leptin . Berberine yasonyezeranso kuti ili othandiza pothandiza kuchepetsa thupi ndi kutayika kwa thupi mwa kulepheretsa puloteni lipoprotein lipase, yomwe imayambitsa mafuta osungirako. Zomwe zimakhudza kutenga berberine mu maphunziro ambiri ndi kulemera, makamaka pakati pa gawo la thupi, ndi chiwerengero chochepa cha thupi (BMI).
Kuchepetsa Chiwindi Chakudya
Azimayi omwe ali ndi PCOS ali ndi chiopsezo chowonjezereka chodwala matenda a chiwindi chifukwa cha ubale ndi ma insulini otetezeka. Berberine wasonyezedwa kuti ndi njira yabwino yothetsera chiwindi cha mafuta. Kuwongolera mayesero asanu ndi limodzi omwe amachititsa kuti anthu azitha kulamulira matendawa, amawoneka kuti berberine yachepetsa kwambiri chiwindi cha mafuta mwa iwo omwe ali ndi matenda osokoneza bongo (NAFLD). Berberine inachepetsa TG ndi chiwindi cha ntchito zamagazi, ndipo zimapangitsa kuti chiwindi chizigwira bwino ntchito. Zapezeka kuti berberine imalimbikitsa NAFLD mwa kupewa mafuta a chiwindi kumanga komanso kulimbikitsanso mavitamini a ma asidi m'matumbo.
Zomwe Muyenera Kudziwa Pokhudza Kutenga Berberine
Kwenikweni, berberine imalekerera koma nthawi zina imayambitsa mavuto a m'mimba kuphatikizapo kunyoza ndi kudzimbidwa, makamaka ngati kugwiritsidwa ntchito mopitirira muyeso.
Mlingo wa mankhwala a berberine kuti upangitse insulini ndi zina zowonjezereka za umoyo ndi 500 mg, katatu pa tsiku (mofanana ndi metformin dosing). Pofuna kupewa GI kukwiya, zingakhale bwino kupititsa mpaka 1,500 mg tsiku lililonse ponyamula 500 mg sabata yoyamba, kuwonjezera 500 mg sabata yachiwiri, mpaka kufika 1,500mg pa sabata lachitatu.
Berberine sichimagwiritsidwa ntchito kwa nthawi yaitali. Palibe deta yomwe ilipo pokhudzana ndi chitetezo cha Berberine pakati pa atsikana kapena mimba yoyambilira. Berberine sivomerezedwa pa nthawi ya mimba kapena lactation.
Berberine angasinthe mankhwala enaake a chiwindi. Chenjezo limalimbikitsidwa ngati mutenga mankhwala ena oyenera monga anti-depressants , MAO oletsera, ochepa magazi, ndi beta-blockers. Kuwunika kawirikawiri kachitidwe ka ntchito ya chiwindi ndikofunika kwa iwo omwe amatenga berberine. Popeza berberine ndi mankhwala othandiza kuchepetsa shuga, imayambitsa shuga wotsika kwambiri, makamaka pamene imagwiritsidwa ntchito ndi mankhwala ena otsika insulini monga metformin kapena supplements monga inositol kapena n-acetylcysteine. Afunseni dokotala musanatenge berberine.
> Zotsatira:
> Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. Kugwiritsidwa ntchito kwa berberine kwa amayi omwe ali ndi matenda a polycystic ovary omwe akudwala mankhwala a IVF. Clin Endocrinol (Oxf). 2014 Mar; 80 (3): 425-31.
> X X ndi al. Lipid kufotokozera za mankhwala ochiritsira a berberine odwala omwe alibe nthenda ya chiwindi cha mafuta osakaniza. 2016 Sep 15; 14: 266.
> Lin L et al. Pulogalamu Yoyamba Yoyendetsa Bwalo la Zotsatira za Berberine pa Mchitidwe Wokha Msinkhu, Kuyeza kwa Ovulation, Mbiri ya Hormonal ndi Metabolic M'madera Ophwanya Akazi Achi China omwe ali ndi Polycystic Ovary Syndrome. PLoS One. 2015; 10 (12): e0144072.
> Wei W, et al. Maphunziro a zachipatala pa zotsatira zafupipafupi za berberine poyerekeza ndi metformin pa zochitika zamagetsi za amayi omwe ali ndi matenda a polycystic ovary. Eur J Endocrinol. 2012 Jan; 166 (1): 99-105.
> Yang J et al. Berberine imapangitsa insulini kukhala wokhudzidwa mwa kulepheretsa mafuta kusungirako ndikusintha ma adipokines maonekedwe a anthu omwe ali ndi matendawa. Evid Based Based Complement Alternat Med. 2012: 363845.