Ngakhale simunasonyezedwe kuti mukhale ndi matenda a polycystic ovary (PCOS), metformin ndiyo mankhwala omwe amalembedwa kawirikawiri kuthandiza amayi omwe akudwala matendawa. Kafukufuku watsopano akuwonetsa mgwirizano pakati pa ntchito ya metformin ya nthawi yaitali ndi kuchepa kwa vitamini B12, komabe ambiri operekera chithandizo chaumoyo samayang'ana kaye B12 kukhala ogwiritsa ntchito a metformin. Kuperewera kwa vitamini B12 kungabweretse mavuto aakulu a ubongo ndi mitsempha.
Nazi zomwe muyenera kudziwa zokhudza vitamini B12 ngati mutenga metformin.
Kodi Metformin Ndi Chiyani?
Metformin imagwira ntchito monga mankhwala othandizira kuchepetsa shuga ndipo imaperekedwa kwa anthu omwe ali ndi matenda a shuga chifukwa chaichi. Mayina ena a metformin amapezeranso glucophage, glucophage XR, glumetza, ndi fortamet.
Metformin imapangitsa kuti magazi azikhala ndi shuga ndi insulini m'njira zosiyanasiyana: Zimapangitsa kuti chiwindi chiwonongeke, chimapangitsa kuti chiwindi chanu, minofu, mafuta, ndi maselo anu azikhala ndi insulini ndipo thupi lanu limachepetsa.
Metformin yasonyezedwa kuti ayambe kuchepetsa insulini komanso ma piritsi (cholesterol) mwa amayi omwe ali ndi PCOS ndipo angathandize kusintha mavenda.
Matenda a Metformin ndi Vitamini B12 Imeneyi
Kupewa Kachilombo Maphunziro a Maphunziro Phunziro (DDPOS) ndilo limodzi mwa maphunziro akuluakulu ndiatali kwambiri a mankhwala a metformin omwe alipo. Kusanthula kwatsopano kwa DDPOS yofalitsidwa mu Journal of Clinical Endocrinology ndi Metabolism inayang'ana pa B12 magulu a anthu omwe ali ndi matenda a prediabetes amene anatenga 850 mg Metformin kawiri tsiku ndi tsiku ndi kuwayerekezera ndi iwo omwe ali ndi placebo.
Mavitamini a vitamini B12 anayesedwa zaka zisanu ndi zisanu ndi zitatu.
Zotsatira za DDPOS zasonyeza kuti kugwiritsa ntchito mankhwala a longformin kwa nthawi yaitali kunachulukitsa chiopsezo cha mavitamini B12. Pa zaka zisanu, 5.2 peresenti ya ogwiritsira ntchito metformin anali ndi masewera otsika a serasi B12. Pa zaka 13, 9.2 peresenti ya ogwiritsira ntchito metformin anali ndi malipiro otsika a B12. Pamene kulamulira kwa msinkhu, kugonana, ndi BMI, kunali 13 peresenti yowonjezera ngozi ya kusowa kwa B12 kwa chaka chilichonse cha ntchito yonse ya metformin.
Zimakhulupirira kuti metformin imatha kuwonongera mavitamini B12 mu leamu ya m'mimba. Sikuti magulu a vitamini B12 okha omwe adakhudzidwa ndi kufufuza kwa DDPOS, koma maseĊµero a homocysteine, chizindikiro cha matenda a mtima, anawonjezeka pa nthawi ya ogwiritsira ntchito metformin.
Kafukufuku wina wasonyeza kuti metformin ingakhudze mavitamini B12 m'miyezi itatu yogwiritsidwa ntchito. Kuwongolera mwatsatanetsatane ndi kufotokozera meta kunayang'ana pa anthu omwe ali ndi mtundu wa shuga 2 ndi amayi omwe ali ndi PCOS omwe anatenga metformin. Zotsatira zawo zapeza kuti mlingo wa metformin uli wapamwamba kwambiri, anthu osowa kwambiri anali ndi vitamini B12 ndipo metformin inachepetsa mavitamini B12 mu zaka ziwiri (zaka zitatu) ndi zochepa (<3 zaka) ntchito.
Kawirikawiri mlingo wa metformin kwa amayi omwe ali ndi PCOS ndi 1,500 mg mpaka 2,000 mg tsiku lililonse. Amayi ambiri omwe ali ndi PCOS amatenga mlingo waukulu wa metformin kuti agwiritse ntchito nthawi yaitali, kuwonjezera chiopsezo chawo chosowa vitamini B12.
Kufunika kwa vitamini B12
Vitamini, B12 ndizofunika kuti thupi liziyenda bwino, kugwiritsira ntchito malingaliro, DNA, komanso maselo ofiira a magazi. Vitamini B12 imapezeka makamaka m'zinthu zamtundu. Anthu omwe amadya zakudya zodyera ayenera kuwonjezera zakudya zawo ndi vitamini B12. Kuchuluka kwa vitamini B12 tsiku ndi tsiku kwa anthu ambiri akuluakulu ndi 2.4 mcg.
Zizindikiro za kuchepa kwa B12 zimaphatikizapo mitundu yambiri ya kuchepa kwa magazi, matenda a ubongo (kuwonongeka kwa mitsempha), kutopa kwanthawi yaitali, kukumbukira kukumbukira, kusokonezeka, kusinthasintha maganizo komanso ngakhale maganizo.
Kuperewera kwa vitamini B12 ndi koopsa kwambiri, kumakhudza maganizo ndi mphamvu ndipo zingayambitse matenda osokoneza bongo osatha. Nthawi zina kutenga multivitamin yomwe imakhala ndi vitamini B12 ikhoza kumabweretsa kusowa kwa ogwiritsira ntchito metformin. Anthu omwe amatenga metformin ayenera kukhala ndi mavitamini awo a vitamini B12 chaka ndi chaka ndikuwonjezera chakudya chawo moyenera. Mtundu wa vitamini B12 wa methylcobalamin mu mawonekedwe ofanana (pansi pa lilime) umakhala wabwino kwambiri ndi thupi.
Kodi Vuto la Vitamini B12 Lidziwika Bwanji?
Magazi amatha kuyesa mavitamini B12. Zakhala zikugwiritsidwa ntchito kuti malemba a ma labulo omwe ali ndi miyezo ya B12 yowonongeka imakhala yochepa kwambiri ndipo zizindikiro za kusowa kwazomwe zingathe kuwonetsera mmunsi mwa 400 pg / ml.
Kuyesa methylmalonic acid (MMA) ndi mayesero ovuta omwe angathenso kulondola mavitamini B12.
Chinthu chofunika: Ngati mutenga metformin, funsani dokotala wanu kuti ayang'ane mavitamini B12 anu pachaka ndikuwonjezera zakudya zanu ndi vitamini B12 kuti muteteze vuto la kusoweka.
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