Ubwino ndi Zoipa Zowirikiza Kaŵirikaŵiri Zochiritsira
Chemotherapy ikhoza kuyambitsa selo lanu loyera kuti ligwetse, zomwe zimakuika pangozi ya matenda. Neutropenia (mlingo wochepa wa mitundu ina ya maselo oyera a magazi) amachiritsidwa ndi Neulasta kapena Neupogen, koma ndi kusiyana kotani, ndipo dokotala wanu amasankha bwanji pakati pawo?
Kusiyanasiyana pakati pa Neulasta ndi Neupogen
Neulasta ndi Neupogen zonse zimapangidwa ndi mapuloteni achilengedwe omwe amadziwika ngati granulocyte -colony stimulating factor (kapena "G-CSF").
Pegfilgrastim (Neulasta) ali ndi polyethylene glycol, "PEG," yomwe imagwiritsidwa ntchito, yomwe imapangitsa molekyulu kukhala yaikulu kotero kuti imakhalabe mu system yanu yaitali kuposa filgrastim (Neupogen).
Kodi Zing'onoting'ono Zambiri Zotani pa Chemo Pakati Panga Ndimasowa?
Neulasta imapatsidwa kamodzi pa kawiri kawiri ya mankhwala apamwamba a mankhwala, pafupifupi maola 24 mutapatsirana mankhwala a chemotherapy, ndipo pasanathe masiku 14 musanalowetsedwe. Neupogen imaperekedwa mu jekeseni zingapo tsiku ndi tsiku mpaka chiwerengero chanu cha neutrophil chibwererenso kumagulu abwino. Mungafunike ma shoti atatu kapena anayi a Neupogen, kapena ochuluka khumi, malinga ndi momwe dongosolo lanu limayendera mankhwala.
Mphamvu ndi Zotsatira Zotsatira
M'mayesero am'chipatala, mankhwalawa onse amafaniziridwa ndi:
- Kugwira ntchito popanga neutrophil
- Kulekerera ndi odwala
- Chitetezo cha ntchito
Ngakhale kuti mankhwala onsewa ndi othandiza kwambiri, phunziro la 2015 linapeza kuti neutropenia yoopsa (yowerengeka kwambiri ya neutrophil) inali yochepa kwambiri kwa anthu omwe anachitidwa ndi Neulasta pa mankhwala a kansa ya m'mawere.
Anthu omwe amalandira Neulasta sakanatha kuchepetsa kumwa mankhwala a chemotherapy kapena kuchepetsa pakati pa matenda opatsirana.
Zotsatira zoyipa zili zofanana. Kupweteka kwa kupweteka ndiko kupweteka kwa mankhwala onsewa, omwe amapezeka ndi 31 peresenti mpaka 26 peresenti ya anthu ku Neulasta ndi 24 peresenti ya anthu ku Neupogen.
Anthu omwe amavutika kwambiri ndi kupweteka kwa mafupa nthawi zina amatha kusankha Neupogen pa Neulasta chifukwa chaichi (ngakhale zili zosavuta kuzigwiritsa ntchito).
Ndalama ndi Kuwonongeka kwa Neulasta ndi Neupogen
Neulasta ndi yokwera mtengo kuposa Neupogen, koma chiwerengero cha mlingo wa Neupogen chofunika chingachepetse kusiyana pakati pa mtengo wa mankhwalawa. Ndikofunikira kukumbukira mtengo wa chipatala cha matenda a neutropenia (ndi chiopsezo chotere cha matenda) chomwe chikufala kwambiri pakati pa omwe alandira Neupogen.
- Katemera umodzi wa 6 mg Neulasta udzawononga pakati pa $ 5,000 mpaka $ 7000, malingana ndi wogulitsa.
- Jekeseni imodzi ya 300 microgram ya Neupogen idzapakati pa $ 300 mpaka $ 350.
- Mmodzi wa jekeseni wa 6 mg wa Neulasta amafanana ndi 10.4 300 microgram jekeseni ya Neupogen.
- Amgen amapereka ndondomeko yoyamba yothandizira kuchepetsa ndalama zothandizira mankhwalawa kwa omwe ali ndi inshuwalansi yathanzi.
Kodi inshuwalansi idzaphimba ndalamazo?
Osati inshuwalansi ya zaumoyo iliyonse yomwe imapereka mankhwala osokoneza bongo adzatengera mtengo wa Neulasta. Musanayambe mankhwala a chemotherapy, funsani ofcologist ngati mungafune Neupogen kapena Neulasta. Mungafunsidwe kuti mulembe fomu yomwe imakulimbikitsani kuti mupeze mtengo wa mankhwalawa ngati inshuwalansi yanu isayilipire.
Ngati simukudziwa ngati inshuwalansi yanu imakhala ndi Neupogen kapena Neulasta, foni foniyo musanayambe mankhwala a chemotherapy kuti mupeze ndondomeko yawo. Iwo angathandize pa mtengo wa Neupogen, koma osati Neulasta. Mutha kulandira chithandizo, koma mukuyenera kukhala ndi Neupogen (jekeseni yambiri) ngati inshuwalansi yanu isaphimbe Neulasta. Ngati oncologist wanu akuwona kuti mankhwala amodzi akhoza kugwira ntchito bwino kuposa ena omwe sali ophimbidwa, angakhale okonzeka kugwira ntchito ndi kampani yanu ya inshuwalansi kuti akonzekeze kufalitsa. Ndikofunika kukhala wothandizira wanu pa chisamaliro chanu cha khansa . Funsani mafunso, ndipo funsani ngati mukufunikira.
Nthawi zina wotsogolera wodwala angakuthandizeni kuthetsa mavuto ngati akuyenera kuwuka.
Kodi Chisankho Ichi Chinapangidwa Bwanji?
Chisankho chogwiritsa ntchito Neulasta kapena Neupogen chimayendetsedwa ndi zofunikira zachipatala. Mankhwalawa samangokhala "icing pa keke" kapena chinthu china chowonjezera; pamene muli ndi neutropenia, muyenera kuchiritsidwa. Funsani dokotala wanu kuti akuthandizeni kulimbikitsa inu ngati kampani yanu ya inshuwalansi sagwirizana kuti igwirizane ndi mankhwala alionse omwe mukuwafuna.
Mlungu uliwonse Chemotherapy ndi Neupogen
Ngati mukukhala ndi mankhwala ochepa a mlungu ndi mlungu, Neulasta sizosankha. Popeza Neulasta ayenera kupatsidwa maola 24 pambuyo pa chemo ndi masiku 14 isanayambe, sizingagwire ntchito limodzi ndi masabata onse. Neupogen idzagwira ntchito bwino ndi sabata iliyonse ya chemo chifukwa imathetsa dongosolo lanu mofulumira ndipo ingaperekedwe nthawi zonse momwe mukulifunira pakati pa miyendo ya chemo.
Sungani pa Zolemba, Zopereka, ndi Zamtengatenga
Ngati mukukhala ndi chemo sabata iliyonse ndikusowa Neupogen shots, mukhoza kusunga njira zingapo. Funsani namwino wanu ngati mungathe kutenga Neupogen shots kunyumba, ndipo ngati zili choncho, aphunzitseni inu kapena wachibale mwanjira yoyenera kupereka jekeseni.
Onetsetsani kutsatira mosamala malangizo osungirako, kukonzekera, ndi jekeseni. Izi zidzakupulumutsani ndalama zothandizira, komanso mapepala a maulendo a maofesi, komanso ndalama zothandizira zowonongeka. Mudzasowa kukachezera kuchipatala chanu ku CBC yowonongeka, kuti muwone kuwerengera kwa magazi anu, mosamala kwambiri pazitsulo zanu za neutrophil .
Kuteteza Matenda
Ndikofunika kukumbukira kuti, ngakhale mutalandira Neulasta kapena Neuopogen, mukhoza kukhala pachiopsezo chachikulu cha matenda. Chemotherapy ikhoza kuchepetsa chiwerengero cha maselo oyera m'magazi anu (cholinga chogwiritsira ntchito mankhwalawa), koma maselo oyera a magazi omwe alipo alipo sangagwire ntchito komanso maselo oyera. Kuphunzira momwe mungachepetsere chiopsezo chotenga kachilombo ka mankhwala a chemotherapy n'kofunika kwambiri chifukwa anthu ambiri sadziwa zinthu zosavuta zomwe angachite kuti athetse chiopsezo chawo.
Pansi pa Neulasta kapena Neupogen
Neulasta ndi Neupogen amatha kuchepetsa chiopsezo chotenga kachilombo ka mankhwala pa mankhwala a chemotherapy, ndipo mankhwalawa tsopano amalola anthu kulandira mankhwala osokoneza bongo kuposa momwe zinalili poyamba. Pali kusiyana kochepa, kuphatikizapo msinkhu waukulu wa neutropenia ndi Neupogen (omwe ali ndi khansa ya m'mawere) komanso kuvutika kwakukulu kwa mafupa a Neulasta.
> Zotsatira:
> Brett Hauber, A., Mange, B., Price, M. et al. Njira Zogwiritsira Ntchito Pegfilgrastim Prophylaxis: Maphunziro Oleza Mtima ndi Odwala Kuchokera Pambuyo Pachigawo. Thandizo Lothandiza ku Khansa . 2018. 26 (1): 251-260.
> Kourlaba, G., Dimopoulos, M., Pectasides, D. et al. Kuyerekezera Filgrastim ndi Pegfilgrastim Poletsa Kuteteza Neutropenia ndi Kusunga Dose Kukula kwa Adjuvant Chemotherapy kwa Odwala Matenda a Kachiwerewere. Thandizo Lothandiza ku Khansa . 2015. 23 (7): 2045-51.