Chifukwa Chake Tili ndi Mphamvu Zochepa ndi Mmene Tingamenyerere
Chinthu china chotchedwa fibromyalgia (FMS) ndi matenda otopa ( ME / CFS ) omwe ali ofanana ndi kusowa kwa mphamvu. Izi ndi zosiyana ndi kutopa kapena kusowa mtima komwe kungabwere ndi kupsinjika maganizo. Titha kufuna kuchita chinachake koma sitingakwanitse.
Choyamba, sizili ngati kutopa komanso kufunikira kugona. Ndizovuta kwambiri, sizikhoza kusuntha kumverera kwa minofu.
Ngati munayamba mwakhalapo mpaka simungathe kuchita, ziribe kanthu momwe mukufunira, ndicho chimene tikukamba. Ngati mwatuluka ndi anesthesia ndi miyendo yanu yokhala yolemetsa kwambiri, mumayipeza. Mwina mungafunike kugona, koma mumayenera kupuma minofu musanachite china chilichonse.
Ndili ndi FMS ndi ME / CFS, komabe kusowa kwa mphamvu kungagwire mwadzidzidzi kwa nthawi yaitali, mosasamala kanthu kuti timapuma kotani. Zitha kuchitika pakati pa ulendo wopita kuntchito, kuntchito, kapena mphindi khumi mutadzuka. Zingakhalenso pomwepo mmawa mmawa ndikukulepheretsani kudzuka.
Sitikumvetsetsa bwino chizindikiro ichi kapena chifukwa chake ndi mbali ya matendawa, koma kafukufuku amasonyeza kuti, makamaka mbali, chifukwa cha zinthu zochepa zomwe zimatchedwa adenosine triphosphate, kapena ATP.
Kodi Adenosine Triphosphate N'chiyani?
ATP imagula mphamvu m'thupi lanu.
Akatswiri a sayansi ya zamoyo nthawi zambiri amachitcha kuti "ndalama zamoyo." Ndilo gwero lalikulu la mphamvu mu maselo onse amoyo. Ndicho chimene mphamvu ya chakudya chanu chasandulika kuti ikhale yowononga thupi lanu lonse.
ATP imapangidwa ndi mitochondria m'maselo anu. Maselo anu amafunikira kuti izigwire ntchito, minofu yanu ikufunika kuti ikhale yogwirizana, chirichonse mu thupi lanu chimafunikira icho kuti chichite monga momwe ziyenera kukhalira.
Adenosine imachitika mwachibadwa m'thupi lanu, ndipo pakati pazinthu zina, imayendera malamulo a magazi kupita ku ziwalo zina. Pankhani ya ATP, ndilo gawo la triphosphate lomwe ndilofunika kwambiri.
Kuti apange ATP, adenosine akuphatikizana ndi magulu atatu a phosphates. Pamene mphamvu ikufunika penapake ndipo ATP imatumizidwa, imodzi mwa phosphates imasweka, kumasula mphamvu. Kenako thupi lanu limalowetsa phosphate kuti likonzenso ATP. Ndi njira yokonzanso yosatha.
Pamene ATP silingapeze thupi lanu kapena chinachake chikulepheretsa njira yobwezeretsanso, ma level ATP akhoza kukhala otsika ndipo amachititsa kufooka kwa mphamvu.
Kutha kwa ATP mu Fibromyalgia
Sitikupeza kafukufuku wochuluka pa udindo wa ATP mu FMS, ndipo maphunziro omwe tili nawo ndi ofunika kwambiri. Mwamwayi, iwo ndi okongola kwambiri poti ma ATP ali otsika mu chikhalidwe ichi.
Kafukufuku wina wa ku Ulaya wofalitsidwa mu 2013 anasonyeza kusagwirizana pakati pa kuchepetsa kupweteka kwa minofu m'manja ndi mapazi mu FMS komanso kuchepa kwakukulu kwa ATP ndi phosphocreatine, yomwe ili ngati thumba la phosphate lomwe thupi lanu limagwiritsa ntchito kuti njira yobwezeretsamo ikhale ikuyaka .
Ntchito yam'mbuyomo inapezeka kwambiri pa ATP m'magulu a anthu omwe ali ndi FMS pamodzi ndi zovuta zina zomwe zimasonyeza kuti thupi silinathe kukhala ndi ATP.
Choncho ngakhale kuti ntchito ikuwoneka kuti ikusowa, ndipo kusowa kwachinyengo kumawathandiza kukhala ndi mphamvu, ndizo zonse zomwe tinganene panopa.
Kulephera kwa ATP mu ME / CFS
Mu ME / CFS, ATP yanyalanyazidwa kwambiri kuchokera kwa ofufuza, mwina chifukwa chakuti kusowa mphamvu kumakhala kosiyana kwambiri ndi ME / CFS kusiyana ndi FMS, komwe kumakhala kovuta kwambiri.
Maphunziro angapo a ME / CFS akuyang'ana ntchito ya mitochondrial m'maselo athandizira chikhulupiriro chokwanira kuti kutsika kwa ATP kumapangitsa kuti thupi lisamagwire bwino ntchito, kutanthauza kuti maselo enieniwo sangagwire ntchito bwino.
Chimodzi mwa zizindikiro zodziwika za ME / CFS ndi post-exertional malaise , yomwe ndi yachilendo komanso yowopsa kwambiri. Kuchuluka kwa ntchito kumafunika kusiyana ndi munthu, koma kumawasiya kuti asamachite ntchito zomwezo tsiku lotsatira, zomwe si zachilendo komanso zachilendo ku matendawa.
Pulogalamu ya 2015 imalumikiza maulendo ochepa a ATP chifukwa cha kuchepa kwa adenosine, zomwe zikutanthauza kuti nthawi yowonetsera nthawi yayitali imakhalapo chifukwa thupi liyenera kutenga poyamba pa adenosine, kenaka pa ATP.
Nkhani yowonjezera yomwe inafotokozedwa mu 2014 ikugwirizana ndi izi, ndi ofufuza akugwirizanitsa zolepheretsa kuntchito ya ATP osati kokha kutengapo ntchito malaise, koma mwinamwake kuyambira kwa matenda omwewo ndi zovuta zina zamagetsi zomwe zimagwirizanitsidwa nazo. Olemba a pepalali awonetsanso kuti kutsika kwa ATP kochepa mu ME / CFS kungachititse kuti anthu azidzipatula pogwiritsa ntchito mphamvu za imfa.
Kuchiza Kutha kwa ATP
Mankhwala omwe amagwiritsidwa ntchito kawirikawiri pa matendawa samayesetsa kuthetsa vuto la mitochondrial kapena kutayika kwa ATP. Komabe, madokotala ena amafotokoza bwino kupambana ndi mankhwala owonjezera omwe amakhulupirira kuti akuthandizira mavutowa. Zina mwazowonjezerekazi zimapereka zofufuzira zopereka umboni wosonyeza kuti zakhala zogwira mtima.
Mwinamwake mumamva za coenzyme Q10 (CoQ10) , yomwe imapezeka mwachibadwa m'thupi lanu ndipo imatha kuthandizidwa ngati chowonjezera. Amatchuka pakati pa anthu omwe ali ndi FMS, ME / CFS, ndi zina zambiri, komanso za thanzi labwino. Mwa zina, ndicho chifukwa thupi lanu limafuna CoQ10 kupanga ATP.
Maphunziro angapo okhudza FMS ndi / kapena ME / CFS amagwirizanitsa ma ATP otsika ndi CoQ10. Kafukufuku wochuluka amasonyezanso kuti CoQ10 zowonjezera mphamvu zimapangitsa mphamvu kutero. CoQ10 zowonjezereka zitha:
- kusintha mphamvu
- kuchepetsa post-exertional malaise
- kuchepetsa kutopa
- kuthandizani kupwetekedwa koyambitsa (hyperalgesia) ya FMS
Zakudya zina zowonjezera nthawi zina zimaphatikizapo kuwonongeka kwa mitochondrial monga:
- carnitine
- kulenga
- D-Ribose
- magnesiamu
- niacinamide (vitamini B3)
Dokotala wanu akhoza kulangiza mankhwala ena kuti akupititse mphamvu yanu mwa kukulitsa ma ATP.
Kumbukirani kuti ngakhale zinthu zakuthupi zingakhale ndi zotsatirapo ndi kusagwirizana ndi zinthu zina zomwe mukuzitenga. Onetsetsani kuti mungalankhule ndi dokotala wanu za mankhwala omwe mumawakonda musanayambe, ndipo onetsetsani kuti mukudziwa momwe mungayambitsire bwino dongosolo lowonjezera .
> Zotsatira:
> Gerdle B, Forsgren MF, Bengtsson A, et al. Kuchepetsa kuchepa kwa ATP ndi PCR mu quadriceps minofu ya odwala fibromyalgia-A 31P-MRS kufufuza. Magazini ya ku Europe ya ululu. 2013 Sep; 17 (8): 1205-15.
> Lengert N, Drossel B. Mu silico kusanthula kusagwirizanitsa ntchito mu myalgic encephalomyelitis / matenda osatopa matenda. Biological physistry. 2015 Jul; 202: 21-31.
> Morris G, Anderston G, Berk M, Maes M. Coenzyme Q10 kuthetsa mavuto a zachipatala ndi a neuropsychiatric: zotsatira zowonjezereka komanso zochiritsira. Matenda a m'magazi. 2013 Dec; 48 (3): 883-903.
> Morris G, Berk M, Galecki P, Maes M. Kutuluka mwadzidzidzi mu myalgic encephalomyelitis / matenda otupa (ME / cfs). Matenda a m'magazi. 2014 Apr; 49 (2): 741-56.
> Morris G, Maes M. Matenda a Mitochondrial mu myalgic encephalomyelitis / matenda otopa matenda omwe amachititsa kuti atseke m'maganizo. Matenda a ubongo. 2014 Mar; 29 (1): 19-36.