Ngati mutenga jekeseni wamkati mwa mlungu wa interferon, muli ndi ngongole kwa katswiri wamagetsi. Izi ndi chifukwa popanda mankhwala amtundu wa pirgylation muyenera kuyamwa interferon katatu pa sabata. Mwachidule, mankhwalawa amachititsa kuti mankhwala anu asakhale ophweka ndipo amakupangitsa kuti azikhala bwino.
Mwachidule
Pegylated interferon, kawirikawiri yotchedwa peginterferon, ndi mawonekedwe omwe amasinthidwa ndi interferon omwe amachititsa chiwindi cha chiwindi C komanso kawirikawiri matenda a hepatitis B.
Kusiyana pakati pa interferon ndi peginterferon ndi PEG, yomwe imayimira molekyu yotchedwa polyethylene glycol. Gulu lachigawenga silichita kalikonse polimbana ndi kachirombo ka HIV. Koma poiika pa interferon (yomwe imamenyana ndi HIV), interferon idzakhalabe mu thupi (makamaka mwazi) motalika kwambiri.
Izi zimawathandiza odwala matenda a chiwindi omwe amatenga interferon chifukwa mmalo mofuna kuyika interferon katatu pa sabata, jekeseni kamodzi kokha kamodzi kokha kakufunika. Kuwonjezera apo, zimapereka mlingo wapamwamba wa yankho la virologic .
Pali mitundu iwiri ya peginterferon, yomwe imagulitsidwa payekha monga Pegasys (yemwenso amadziwika kuti peginterferon alfa-2a) ndi PegIntron (amadziwika kuti peginterferon alfa-2b). Zonsezi zimakhala ndi zochita zofanana za pharmacokinetic, ndi zosiyana zochepa pakati pa ziwiri.
Zogwira mtima
Musanayambe kumwa mankhwala opatsirana mwachindunji (DAAs) mu 2013-kuphatikizapo mankhwala Sovaldi , Harvoni , Daklinza ndi Viekira Pak , pakati pa ena-njira yowunikira kwambiri yochizira matenda a chiwindi cha matenda a hepatitis C anali ndi kuphatikizapo peginterferon ndi ribavirin .
Mankhwala awiriwa amadziwika kuti ali ndi zotsatira zoyenera za mankhwala, zina zomwe zingakhale zozama. Komabe, mankhwala ophatikizanawa adakwanitsa kukwaniritsa yankho la virologic (machiritso a mankhwala) pafupifupi 50 peresenti ya milandu.
Masiku ano, ndi a DAAs atsopano, kugwiritsa ntchito peginterferon kwagwa kwambiri, ngakhale kuti nthawi zina imayesedwa nthawi ya matenda oyambirira a chiwindi ndi / kapena odwala omwe asanagwiritse ntchito mankhwalawa.
Ulamuliro
Peginterferon imayikidwa kamodzi pamlungu. Mlingo weniweniwo udzakhala wosiyana malinga ndi zifukwa zingapo, kuphatikizapo genotype ya kachilombo ka HIV , mtundu wa peginterferon womwe mukugwiritsira ntchito, ndipo mankhwala omwe ali nawowa adzagwirizanitsidwa nawo. Namwino wanu adzakuphunzitsani momwe mungaperekere jekeseni moyenera, kawirikawiri pansi pamtambo (pansi pa khungu). Peginterferon ayenera nthawizonse kukhala firiji, ndipo singano zisamagwiritsiridwenso ntchito kapena kugawa.
Zotsatira Zotsatira
Zotsatira za peginterferon zidzasiyana pakati pa munthu ndi munthu, ndi ena omwe akuyang'anira zidzakhala zovuta kwambiri pamene ena akuwona zizindikiro akuganiza kuti sungatheke. Zotsatira zofala zomwe zimagwirizanitsidwa ndi ntchito ya peginterferon ndi:
- Zizindikiro zofanana ndi matenda a chimfine (kupweteka mutu, malungo, kuzizira, minofu ya minofu)
- Kusagona
- Kusokonezeka maganizo ndi kusintha maganizo kumasintha
- Kukhumudwa
- Nsowa ndi kusanza
- Kuphulika khungu
- Kutopa kwambiri
- Kutaya njala
- Kutaya thupi
Odwala pa chithandizo nthawi zambiri amalankhula za Riba Rage, chikhalidwe chomwe chikuyimiridwa ndi kukhumudwa kawirikawiri ndi mwadzidzidzi, nthawi zina kupwetekedwa mtima pamtima. Ngakhale kuti mawuwa akusonyeza chifukwa chake ndi ribavirin, nthawi zambiri zimagwirizanitsidwa ndi peginterferon. Nthaŵi zina amatha kupanikizika kuti athetse vutoli, makamaka kwa odwala omwe ali ndi matenda omwe alipo kale.
Mtengo
Chithandizo chokwanira chokwanira ndi chokwera koma mwachisangalalo, ndi a DAA atsopano, nthawi ya mankhwala ndi yayifupi kwambiri kuposa kale.
Medicaid, Medicare ndi inshuwalansi yapayekha nthawi zambiri amawononga mtengo wa interferon pamene chithandizo cha hepatitis C chivomerezedwa. Pothandizira mankhwala omwe angagwiritsidwe ntchito ndi odwala omwe ali oyenerera, angathandizidwe ndi odwala omwe ali oyenerera, komanso pulogalamu yothandizira odwala (PAP) kwa odwala omwe sali ovomerezeka kapena ochepa.
Contraindications
Anthu ena omwe ali ndi matenda a hepatitis C sayenera kutenga peginterferon. Izi zikuphatikizapo anthu omwe ali ndi zifukwa zotsatirazi:
- Matenda oyambirira a chiwindi, mtima, impso kapena mapapo
- Zovuta zina zomwe zimagwira ntchito
- Kuvutika maganizo kwakukulu kapena zochitika zina zamaganizo
- Mimba
- Kuyamwitsa
Nthawi zonse onetsetsani kuti dokotala wanu ali ndi mbiri yakale ya zamankhwala, kuphatikizapo zambiri zokhudza matenda ena omwe mungakhale nawo (mwachitsanzo, kachilombo ka HIV , matenda a shuga) kapena ndondomeko iliyonse yomwe mungafunike kutenga.
Zotsatira:
Katzung, BG. Basic and Clinical Pharmacology, 10e. New York, McGraw-Hill, 2007.
Brenner GM, Stevens, CW. Pharmacology, 2e. Philadelphia, Saunders Elsevier, 2006.
Genentech. "Pegasys: Mfundo zazikulu za Kufotokozera Mauthenga . "
Merck "PegIntron: Mfundo zazikulu za Kufotokozera."