Kumvetsetsa Chiwindi cha Chiwindi C "Chithandizo"
Kuyankha kwa virologic (SVR ) yowonjezera kwa anthu omwe ali ndi matenda a hepatitis C kumangotanthauza kuti palibe umboni wa kachirombo ka hepatitis C m'magazi awo atalandira chithandizo cha hepatitis C. SVR ndi cholinga chachikulu cha mankhwala a HCV ndipo, nthawi zambiri, amatha kutchulidwa kuti "mankhwala" ngati kachilombo ka HCV sichikupezeka mosavuta patatha masabata makumi awiri ndi awiri mutatha kuchiza.
Pafupifupi nthawi zonse, anthu omwe ali ndi SVR ya masabata makumi awiri ndi awiri (24) samawoneka kuti ali ndi kachilombo ka HIV (ie, kubwerera kwa HIV). Kafukufuku wambiri amasonyeza kuti mitengo yowonjezera ndi yochepa ngati 1 peresenti mpaka 2 peresenti pazochitika zoterozo.
Kufotokozera SVR ndi Mayankho ena a Virologic
Pambuyo poyambitsa matenda a hepatitis C, magazi amayesedwa kuti ayese ntchito ya tizilombo. Cholinga chachikulu ndichokwaniritsa nthendayi yosadziwika. "Zosatheka," mu nkhaniyi, sizikutanthawuza zero kapena kusakhala kwathunthu kwa mavairasi m'thupi; M'malo mwake, amadziwika kuti alibe kachilombo ka HIV kamene kamapezeka m'magazi pogwiritsa ntchito matekinoloje omwe akuyesedwa.
Gawo lirilonse la kulabadira lapatsidwa mndandanda, ndi magawo ena okhudzana ndi chitsimikizo chachikulu kapena chochepa cha kuchiza chithandizo. Yang'anani pa tchati ichi, pansipa.
| Nthawi | Meaning | Tanthauzo | Kuthamangitsani |
| RVR | Werenganinso mwamsanga | Matenda osadziwika omwe ali ndi masabata anayi akuchiritsidwa | Kawirikawiri amatha kupeza SVR |
| RVR | Kuyankha kwa virali mofulumira | Matenda osadziwika omwe ali pa sabata 12, motsatira RVR yoyamba | Kawirikawiri amatha kupeza SVR |
| EVR | Yankho lakumayambiriro kwa tizilombo | Nthenda yosaoneka yosawerengeka kapena kuchepa kwa 99 peresenti ya kuchepa kwa vutolo ndi sabata 12 | Kulephera kukwaniritsa EVR kumagwirizanitsa ndi mwayi wosachepera 4 peresenti yokwaniritsa SVR |
| ETR | Kutha kwa kuyankhidwa kwa mankhwala | Matenda osadziwika omwe amaperekedwa kumapeto kwa sabata 12 | Sizothandiza pakulosera zotsatira za mankhwala |
| Werengankhani wapadera | Akhoza kukwaniritsa EVR koma sangathe kukhala ndi kachilombo kosawerengeka kwa masabata 24 pambuyo pomaliza mankhwala | Akumva kusalidwa kwa mankhwala | |
| Wosayankha wosamva | Simungathe kukwaniritsa EVR ndi sabata 12 | Chithandizochi chimathetsedwa ngati EVR sichikwaniritsidwa pa sabata 12 | |
| SVR | Yankho loteteza tizilombo | Zikhoza kuthandizira kukhala ndi ma ARV khumi ndi awiri (SVR-12) ndi masabata 24 (SVR-24) mutatha kumaliza mankhwala | SVR-24 imatengedwa ngati "mankhwala," ndipo odwala omwe ali ndi SVR-12 amakhala okhoza kukwaniritsa SVR-24 |
Kuwonjezera Mipata Yanu Yopindulitsa SVR
Chimodzi mwa zifukwa zenizeni za kupambana kwa SVR ndi nthawi, ndi mankhwala opititsa patsogolo omwe akuthandiza odwala kuposa mankhwala ochedwa. Pochiza matenda anu asanawononge chiwindi (kapena, kuwonongeka), mumakhala ndi mwayi wabwino wodwala kuchipatala kwa HCV.
Kuonjezera apo, mankhwala opatsirana pogwiritsa ntchito mankhwala atsopano (DAAs) athandiza kwambiri anthu omwe ali ndi matenda a HCV osatha. Ngakhale anthu omwe ali ndi matenda a chiwindi , amene kale anali ndi mwayi wokwana 50/50, mankhwala a SVR adakwera pang'onopang'ono kufika 95 peresenti komanso pamwamba pazifukwa zambiri.
Mayesero a anthu a m'zaka zitatu (III) awonetsa kuti mankhwalawa ndi awa: omwe ali ndi kachilombo ka HIV:
- Daklinza (daclatasvir) ogwiritsidwa ntchito ndi Sovaldi: 98% ndiive ndipo 58 peresenti akudwala matenda a chibwibwi
- Harvoni (sofusbuvir + ledipasvir) : 99 peresenti ndi 94 peresenti
- Sovaldi ( sofosbuvir ) yogwiritsidwa ntchito ndi ribavirin + peginterferon kapena ribavirin yekha: 82 mpaka 92 peresenti
- Technivie (ombitasvir + paritaprevir + ritonavir) : 99 peresenti yosazindikira komanso yodziwa zambiri
- Viekira Pak (ombitasvir + paritaprevir + ritonavir yogwirizanitsidwa ndi dasabuvir) : 95 peresenti yosazindikira komanso yodziwa zambiri
- Olysio (simeprevir) yogwiritsidwa ntchito ndi ribavirin + peginterferon: 80 mpaka 85% ndiïve
- Zepatier (grazoprevir + elbasvir) yogwiritsidwa ntchito popanda kapena ribavirin: 95 peresenti yopanda kanthu
Chimene Sichikukwaniritsa SVR Zikutanthawuza
Ngakhale cholinga cha chithandizo cha HCV ndicho kuthetseratu kachilombo ka HIV ndikulola munthu kukhala ndi moyo wathanzi, wodwala matenda a chiwindi, wodwala sayenera kukhumudwa ngati sakwanitsa kukwaniritsa zolingazi.
Ngakhale mutakhala ndi yankho laling'ono, kafukufuku wasonyeza kuti ubwino wa chiwindi ukhoza kukhala wozama-osati kungowonjezetsa njira ya matenda koma nthawi zina kumatsitsimutsa fibrosis, ngakhale kwa omwe ali ndi chiwonongeko cha chiwindi.
Ngati mukulephera mankhwala anu oyamba kapena achiwiri, mutengereni zotsatira za magazi ndi dokotala wanu. Ngati mukuganiza kuti mwakonzeka kuyesa kachiwiri, dokotala wanu akhoza kuchita mayesero angapo kuti adziwe mankhwala omwe angakupatseni mwayi wopambana wopeza SVR.
Kulimbana ndi Chiwindi cha Chiwindi
Musalole kuti matenda a hepatitis C asokonezeni. Pali thandizo.
Kuwonjezera pa kufunsa abwenzi anu ndi achibale anu kuti akuthandizeni paulendo wanu, mutha kupeza chitonthozo cholowa m'gulu la chiwopsezo cha hepatitis C pa Intaneti kapena gulu lothandizira matenda a chiwindi. Komanso, kuphunzira zambiri za zakudya zowonjezera matenda a chiwindi zingathandize kuti mukhale bwino komanso mutha kusintha njira yothetsera vutoli.
> Zotsatira:
> Chopra, S., ndi D. Muir. Kuchiza Kuchepetsa Matenda a Hepatitis C Wachilombo Choyambitsa Genotype 1. Kupititsa patsogolo . Kusinthidwa 09/14/16.
> Kattakuzhy, S., Wilson, E., Sidharthan, S. et al. Malingaliro Ovomerezeka Omwe Amagwirizana ndi Virologic Omwe Ali ndi Mphindi 6 Wophatikizana Mmodzi Wothandizira Kulimbana ndi Kutupa kwa Chiwindi Mphamvu Yachilombo kwa Odwala Amene Akudwala Matenda a Chiwindi. Matenda opatsirana pogonana . 2016. 62 (4): 440-7.
> Kattakuzhy, S., Wilson, E., Sidarthan, S. et al. Kusinthika kwa Kutsutsana Kosakaniza Zosiyanasiyana Pa Nthawi Yoyamba Kuchiza, Kulephera kwa Vuto, ndi Kuchiritsidwa Kwambiri ndi Kuchita mwachindunji Antiviral Therapy (Mayeso a NIH SYNERGY). Msonkhano wa AASLD; 2015; chosamveka 220.
> Smith-Palmer, J., Cerri, K., ndi W. Valentine. Kupindula ndi Vuto la Virologic Limene Likulimbikitsidwa mu Hepatitis C: Kusanthula Mwachidziwitso kwa Clinical, Economic and Quality of Life Benefits. Matenda a BMC Opatsirana . 2015. 15:19.