Interferon ndi mankhwala omwe amatsanzira mapuloteni m'thupi lomwe chitetezo cha mthupi chimagwiritsa ntchito kuwononga mavairasi. Pegylated interferon ndi mawonekedwe osinthika a mankhwala omwe amatha kukhalabe m'thupi nthawi yaitali, omwe amapereka chithandizo chabwino. Gulu la polyethylene glycol (PEG) limaphatikizidwira ku interferon, ndondomeko yotchedwa apgylation, yomwe imagwiritsidwanso ntchito ndi mitundu ina ya mankhwala.
Mitundu iwiri ya pegylated interferons ilipo ndipo imagwiritsidwa ntchito pochiza matenda a chiwindi cha Hepatitis C.
- Peginterferon alfa-2a: Amatchedwanso alfa-2a, dzina la malonda Pegasys.
- Peginterferon alfa-2b: Amatchedwanso alfa-2b, dzina la malonda PegIntron.
Iwo ankaonedwa kuti ndi mankhwala omwe amasankhidwa, omwe amagwiritsidwa ntchito ndi ribavirin, ndipo alembedwa pa List of Health List List of Medicine Essential. Chithandizo cha HCV chikusintha ndi kuvomereza Sofosbuvir (Sovaldi) ndi Simeprevir (Olysio) mu 2013 ndi FDA. Mankhwala atsopanowa ndi ena omwe atsimikizika kuwatsata akhoza kuchotsa mankhwalawa monga chithandizo chovomerezeka.
Kusiyana kwakukulu pakati pa awiriwa pegylated interferons ali mu dosing. Alfa-2a amagwiritsidwa ntchito monga mlingo wokhazikika mlungu uliwonse. Alfa-2b amagwiritsidwa ntchito monga mlingo wa mlungu ndi mlungu wochokera kulemera kwa wodwalayo. Pali kusiyana kosiyana pakati pa mankhwala awiriwa, koma amakhala ochiritsira ndipo amagwiritsidwa ntchito ndi dokotala .
Mwachitsanzo, alfa-2a amakhala ndi mavitamini ambiri pambuyo pa jekeseni ndipo amagawidwa makamaka m'magazi ndi ziwalo. Koma alfa-2b ali ndi kuyamwa mofulumira komanso kufalitsa kwakukulu m'thupi.
Kusiyanasiyana kwa Kugwira Ntchito
Mpaka mu Januwale 2008, palibe deta yomwe inkayerekeza mwachindunji mankhwala awa awiri. Izi zasintha ndi phunziro lalikulu lachipatala lotchedwa IDEAL komanso zofananitsa zamagetsi.
Izi zimapereka zotsatira zochititsa chidwi zomwe zimathandiza madokotala kumvetsetsa za mankhwala amphamvu otere a chiwindi a chiwindi .
Kusanthula kwa IDEAL - Kuchita Diso Pogwiritsira Ntchito Momwe Mungagwiritsire Ntchito Pogwiritsa Ntchito Njira Zomwe Zimagwiritsidwa Ntchito Poyesa Opaleshoni ya Optimal Pegylated Interferon - ikuphatikizapo anthu 3070 mu kuyesedwa kosasinthika. Zinagwirizananso chimodzimodzi pakati pa alfa-2a ndi alfa-2b mu chiwerengero chotsatira cha virological reaction . Alfa-2a anali ndi chiwerengero cha 41% ndipo alfa-2b anali ndi SVR ya 39%.
Koma mlanduwo sunatsekedwe. Maphunziro ena awiri adapeza kusiyana kwakukulu pakati pa mankhwala awiriwa, ndi alfa-2a wopambana momveka bwino ndi mitengo yoposa 12% yabwino mu SVR.
Kupenda mowonjezereka kwa odwala 3518 kuchokera ku mayesero asanu ndi awiri osagwiritsidwa ntchito mosavuta kunapeza zotsatira zabwino ndi alfa-2a, ngakhale kuti zinapanga mlingo wapamwamba wa neutropenia. Neutropenia ndi kuchepetsa chiwerengero cha maselo oyera a magazi. Izi ndi zotsatira zoyipa zomwe sizili zoyenera, monga maselo oyera a magazi ndi gawo lalikulu la chitetezo cha thupi. Zidzakhala zocheperachepera, mutha kutenga kachilombo koyambitsa matenda ndipo simungathe kulimbana ndi mabakiteriya ndi mavairasi.
Zotsatirazi zikhoza kuganiziridwa pokhapokha atalandila chithandizo. Koma mankhwala atsopano angasokoneze mavitamini monga chithandizo cha kusankha kwa chiwindi cha matenda a chiwindi.
Umenewo ndiwo mtundu wa kafukufuku ndi chitukuko. Zitha kukhala zosasintha kuti muyereze mankhwala awiriwa ngati mankhwala atsopano.
Zotsatira:
Berenguer M, Wright TL. Hepatitis C. Mu: M Feldman, LS Friedman, LJ Brandt (eds), Matenda a m'mimba ndi Matumbo, 8e . Philadelphia, Elsevier, 2006. 1701.
Hepatitis C Mafunso kwa Ophunzira Zaumoyo, Oktoba 14, 2015. Zomwe Zimayambitsa Matenda ndi Kupewa Matenda
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