Mzere wa maselo a lymphoid uli ndi maselo a m'magazi omwe amayamba m'kasupa mumtundu wotchedwa hematopoiesis, ndipo amachokera ku selo lopangidwa ndi wodwalayo.
Hematopoiesis
Kupangidwa kwa "maselo" onse "kumayambira m'mafupa" mu njira yotchedwa hematopoiesis . Mwa njira iyi, mitundu yonse ya maselo a magazi imachokera ku seti ya hematopoietic stem .
Selo loyambirira, lomwe limatchedwanso selo lopangidwa ndi maselo ambiri, lingathe kufaniziridwa ndi Adamu mu Baibulo, monga "selo la bambo" limene maselo ena onse amagazi amafikira. Maselo amenewa amanenedwanso kuti pluripotent amadziwika maselo, kutanthauza kuti akhoza kukhala ndi mitundu yosiyanasiyana ya maselo.
Maselo oyambirira a maselo amapezeka pamene selo iyi ya pluripotent ikutsatira imodzi mwa njira ziwiri zotukula zomwe zimatchedwa maselo. Pulojekiti ya pluripotent imatha kusiyanitsa pakati pa myeloid cell line kapena lymphoid cell line.
Cell Lemphoid Stem - Lymphoblast
Mzere wa maselo a lymphoid umayamba ndi maselo a lymphoid, omwe amadziwikanso ngati khungu la lymphoblast kapena lymphoid. Imeneyi ndi mphanda waukulu pamsewu pamene maselo onse a mzerewu amayamba ndi khungu la lymphoid, pamene maselo onse a myeloid line (monga neutrophils, macrophages, ndi maselo ofiira a m'magazi) amayamba ndi seloid progenitor cell.
Ma cell Cell Line Lymphoid
Lymphoid progenitor cell (lymphoblast) amatha kusiyanitsa kwambiri mwapadera mu maselo omwe ndi awa:
- Ma lymphocytes B - B lymphocytes kapena "maselo B amayesetsa kuteteza thupi lanu ku matenda pogwiritsa ntchito ma antibodies.
- Ma lymphocytes T - T tymphocytes, kapena "T maselo" ndi maselo a chitetezo cha mthupi omwe amapeza, kupha, ndi kukonzekera nkhondo pazinthu zakunja monga mabakiteriya, mavairasi, ndi maselo a khansa.
- Selo yakupha zachilengedwe - maselo opha thupi ndi maselo amphamvu a chitetezo cha mthupi omwe amachititsa kuthetsa maselo a khansa ndi maselo omwe ali ndi kachilombo ka HIV.
Maselo a Lymphoid ndi Chitetezo
Maselo amtundu wa Lymphoid amapanga pafupifupi 15% a maselo ali ndi thanzi labwino. Maselo amtundu wa Hematopoietic amapitiriza kusiyanitsa m'maselo a lymphoid omwe amatha kupatulira mosalekeza m'maselo okhwima omwe amapanga selo la lymphoid. Zikuoneka kuti fupa la fupa limatulutsa maselo oyera oyera okwana 100 miliyoni pa ola limodzi.
Lymphoid Malignancies
Khansa yokhudza maselo mu mzere wa lymphoid ndi awa:
- Mafupa Osapanga Hodgkin - Mafupa Osati a Hodgkin amakhala ndi magulu osiyanasiyana a maimfine omwe angaphatikizepo maselo ena kapena maselo T. Mankhwalawa amapezeka pazifukwa 10 zakufa kwa odwala khansa kwa amuna ndi akazi.
- Hodgkin lymphomas - Hodgkin lymphomas amakhalanso ndi khansa yowonongeka, ndipo pakali pano ndi khansa yomwe imapezeka kwambiri pakati pa achinyamata a zaka 15 ndi 25.
- Mthempha ya m'magazi yambiri (ALL) - Acute lymphocytic khansa ya m'magazi ndi khansa yomwe imaphatikizapo mitsempha yotupa - maselo omwe amapitirira kukhala maselo a B, T, ndi maselo achilengedwe. Ndilofala kwambiri kwa ana osakwana zaka khumi koma akhoza kuchitika pa msinkhu uliwonse.
- Lymphocytic leukemia (CLL) - Chronic lymphocytic khansa ya m'magazi ndi khansa imene ku United States imakhudza kwambiri ma lymphocyte B. T cell CLL, mosiyana, ndi wamba m'madera a Japan.
Zotsatira:
> Liu, A., Wang, Y., Ding, Y. et al. Kudula Mphuno: Kuwonjezeka Kwambiri kwa Maselo a Hematopoietic ndi Common Lymphoid Progenitor Depletion Amafuna Hematopoietic-Derived, Cell-Autonomous TLR4 mu Mtundu Wopanda Endotoxin. Journal of Immunology . 2015. 196 (6): 2524-8.
Sieff, C. Phunziro la hematopoiesis ndi maselo ofunika kwambiri. Zaposachedwa. Kusinthidwa 05/26/15. http://www.uptodate.com/contents/overview-of-hematopoiesis-and-stem-cell-function
Liang, H., ndi J. Zuniga-Pflucker. Hematopoiesis: kuyambira pachiyambi mpaka kubwezeretsedwa kwa chitetezo cha mthupi. Kafukufuku wa Cell Cell Stem & Therapy . 2015. DOI: 10.1186 / s13287-015-0051-z