Lymphoma ndi dzina lalikulu la khansa zambiri zokhudzana ndi khansa zomwe zimachokera ku lymphocytes. Magulu awiri akuluakulu a lymphoma ndi Hodgkin lymphoma (HL) ndi omwe si a Hodgkin lymphoma (NHL) .
Mantle cell lymphoma (MCL) ndi imodzi mwa magawo osiyanasiyana a NHL . Kwenikweni, ndizimene siziri Hodgkin lymphoma zomwe zimachokera ku B-lymphocytes.
MCL Statistics
- Ndizochepa - ku US, pafupifupi magawo asanu ndi limodzi a masewera olimbitsa thupi omwe si a Hodgkin ndi MCL.
- Izi zimakhudza amuna kuposa akazi.
- Zimakhudza anthu omwe ali ndi zaka zoposa 50, omwe ali ndi zaka zapakati pa zaka 60.
Zizindikiro
- Zizindikiro zimakhala zofanana ndi za mitundu ina ya NHL , chifukwa chakuti chizindikiro chofala kwambiri ndi chimodzi kapena zambiri zopanda kupweteka .
- Zizindikiro zazikulu monga usiku, kutentha , komanso kutayika kwadzidzidzi n'zotheka.
- MCL ikhoza kufalikira pamimba, ndipo ngati izi zichitika, zikhoza kuyambitsa zizindikiro monga kutsekula m'mimba ndi kupweteka m'mimba.
Kufufuza ndi Kufufuza
MCL ikuwoneka ngati otsika kwambiri la lymphoma pansi pa microscope, malinga ndi CancerResearchUK, ndi ma lymphomas otsika omwe ali ndi maselo omwe amawoneka ngati maselo achibadwa; Komabe, MCL ikhoza kukhala ngati lymphoma yapamwamba kwambiri, ikukula mofulumira. Maselo a Lymphoma akhoza kufalikira panthawi yomwe amadziwa - m'matumbo, mafupa ndi mphala.
Kuchiza ndi Zotsatira
Chemotherapy kuphatikizapo othandizira ena amagwiritsidwa ntchito pochiza MCL.
Kuphatikizidwa kambirimbiri kwa chemotherapy plus rituximab (Rituxan) kumagwiritsidwa ntchito. Bortezomib (Velcade) angagwiritsidwe ntchito pochiza odwala omwe abwereranso matenda ndipo avomerezedwa kwa odwala osapatsidwa mankhwala. Ibrutinib (Imbruvica) imavomerezedwa kwa odwala omwe ali ndi MCL .
Mankhwala ndi achilendo pokhapokha atapezeka msanga . Cholinga cha chithandizo ndikuteteza matendawa kwa nthawi yaitali.
Komabe, MCL imayesedwa ndi mayesero ambiri omwe amapita kuchipatala kuti aphunzire kusintha kwa chithandizo.
N'chifukwa Chiyani Amatchedwa Cell Lymphoma?
Mukamamva mawu akunja, mwina mumaganizira za denga limenelo pamwamba pa malo amoto komwe zithunzi za banja ndi tchotchkes zimasungidwa. 'Chovala' m'katikati mwa selo lymphoma chimagwira pa tanthauzo losiyana - yonena za chovala kapena shawl; likhoza kukhala liwu, kuvala kapena envelopu - monga "kulemera kwakukulu komwe kumadutsa mapiri."
'Chovala' m'kati mwa selo lymphoma poyamba chinatanthawuza malo omwe maselo omwe poyamba ankaganiza kuti amagwira nawo makamaka mu malignancy. Senti cell lymphomas inkagwirizanitsidwa ndi dera lamapiri la ma lymph node follicles - maselo omwe amayzungulira ndi kutsegula chinachake chotchedwa germinal pakati, ndipo zonsezi zimafotokozedwa mwatsatanetsatane mu gawo lotsatira.
Mawu akuti mantle cell lymphoma anapangidwa m'zaka za m'ma 1990 pofuna kutchula mtundu wina wa maymphmasi omwe ali ndi masinthidwe atsopano, ndipo lero akuganiza kuti kokha khungu la maselo a lymphomas ali ndi "malaya" a khansara. MCL ikhoza kukhala ndi mawonekedwe osiyanasiyana mosiyana ndi microscope, koma kugwirizanitsa kwa malo ovala zovala za follicles kumatanthauzira chiyambi cha dzina.
The Follicle ndi Mantle
Chifaniziro chomwe chili pamwambapa ndi chithunzi, kapena chidutswa chimodzi m'matumbo onse, monga momwe akuwonera pogwiritsa ntchito microscope yowala pamakono amphamvu. Kagawo kameneka kamasokonezedwa ndi kuvala galasi kuti muwone ma selo osiyanasiyana ndi momwe iwo aliri bungwe mkati mwa mfundoyi.
Mdima wamdima kapena ovals omwe mumaphunzira kuwerenga minofu - makamaka kumbali ya node - amatchedwa follicles. Mapuloteni amapanga mitsempha yamatenda, ndipo amatha kupanga ziwalo zina za thupi. Mapulogalamu ambiri omwe ali pamwambawa ali ndi B-maselo, kapena B-lymphocytes, omwe ali mtundu wa selo loyera la magazi.
Malinga ndi kumene ma B-maselowa ali mkati mwa follicle, akhoza kukhala ndi ntchito zosiyana.
Ngati mutayang'anitsitsa pa follicles, mukhoza kuona kuti ena mwa iwo ali otumbululuka pakati ndi wofiirira wofiira panja . Malo owala kwambiri amadziwika ngati nyongolosi ya follicle pamene mdima wakunja umadziwika ngati chovala.
B-maselo akhoza kukula kuti apange ma antibodies omwe amamanga 'ma tag,' kapena antigen, pa othawa monga mabakiteriya. Ngakhale malo ophulika omwe ali ndi ma B-maselo omwe akukula mofulumira kupanga ma antibodies omwe angakwaniritse antigens pa othawa, dera lamdima lakuda liri ndi ma B-maselo amene akupumula ndi omwe ali ndi 'kukumbukira' ma antigen omwe anakumana nawo pa othawa akale .
Zotsatira za MCL pamene B-lymphocyte m'mphepete mwa chipolopolo cha lymph node - chigawo cha mantle - chimasinthidwa, kapena choipa. B-lymphocyte yosandulika imakula mwa njira yosayendetsedwa, zomwe zimapangitsa kuti maselo a lymphoma asungidwe, omwe amachititsa kuti maselo a mitsempha awonjezeke.
Zotsatira:
Kafukufuku wa khansa UK. Mantle Cell Lymphoma.
Leukemia ndi Lymphoma Society. Mantle Cell Lymphoma Facts .
Man-Hodgkin Lymphomas, okonzedwa ndi James O. Armitage, Bertrand Coiffier. Lippincott Williams & Wilkins, Nov 1, 2009.