Pamene maselo a magazi amakula, "mabanja" osiyanasiyana amachokera ku maselo opangira magazi. Mzere wamaselo a myeloid amaimira banja limodzi lotero. Maselo mu mzere wamaselo a myeloid ndiwo omwe amachokera ku maselo a myeloid, ndipo pamapeto pake adzakhala maselo akuluakulu a magazi, omwe akuwonetsedwa apa:
- Basophils
- Neutrophils
- Eosinophils
- Monocytes (alipo m'magazi)
- Macrophages (alipo m'matumba osiyanasiyana)
- Erythrocytes (maselo ofiira a magazi)
Motero, mitundu yonse ya maselo pamwambapa imayimira chinthu chomaliza kapena zotsatira za kukula kwa banja la myeloid.
Ndilo mzere wa maselo omwe amakhudzidwa ndi "malingaliro a myeloid" monga myelogenous leukemia (AML) , omwe ali ndi chiwerengero chachikulu cha matenda omwe amapezeka chaka chilichonse, komanso matenda aakulu a khansa ya m'magazi (CML) , yomwe imapezeka pafupifupi 6,660. chaka ku United states.
Mtheradi
Maselo ofiira , maselo oyera a magazi, ndi mapuloletti onse aika ziyembekezero za moyo, ndipo amasinthidwa mosalekeza. Maselo amadzimadzi opanga magazi - omwe amakhala makamaka m'mafupa akuluakulu - kuchulukitsa ndikupanga anthu osiyanasiyana, kapena mzere wa maselo.
Maselo okhwima onse okhwima angathe kuyang'ana mzere wawo ku selo limodzi, selo lotchedwa hematopoietic stem cell (HSC), lofanana ndi "Adamu ndi Eva" la maselo onse a magazi.
Maselo amenewa amagawanitsa - onse kuti adzilowe m'malo awo ndi kupanga "maselo obadwawo." Pakati pa mbadwa za HSC, pali mitundu yosiyanasiyana ya maselo obadwapo: pali wodwala wamkulu wa lymphoid komanso wobadwa myeloid. Mphanda uwu pakati pa lymphoid ndi myeloid mzere ndi waukulu.
Mtsogoleri aliyense akhoza kupatsa mabanja ake osiyana a maselo a magazi. Maselo oyera omwe amadziwika kuti lymphocytes amayamba kuchokera ku lymphoid progenitors, pamene maselo oyera a m'magazi osiyanasiyana, maselo ofiira a m'magazi ndi mapiritsi amachokera kwa odwala myeloid. Maselo a myeloid mzere amakhala ndi pafupifupi 85% a maselo a marrow, kwathunthu.
Myeloid Malignancies
Malinga ndi American Cancer Society, odwala ambiri okhala ndi myeloid leukemia (AML) ovuta kwambiri amakhala ndi maselo oyera kwambiri m'magazi awo, osati maselo ofiira a magazi kapena mapiritsi. Maselo ambiri a magazi angakhale myeloblasts - nthawi zambiri amatchedwa kuphulika - omwe ali maselo omwe amapanga magazi omwe sapezeka mumagazi ozungulira. Maselo oterewa samagwira ntchito ngati maselo oyera, okhwima.
Odwala ambiri omwe ali ndi mitsempha ya m'mitsempha yambiri (CML) ali ndi maselo ochuluka kwambiri a magazi omwe ali ndi maselo ambiri, oyambirira. Zina mwa maselo oyerawa amatha kuphulika koma kawirikawiri amakhalapo pang'onopang'ono kuposa AML. Nthawi zina odwala CML angakhale ndi maselo ofiira a magazi kapena mapiritsi a magazi.
Zonse za AML ndi CML, maselo a maselo amagazi akhoza kukhala ndi maganizo a khansa ya m'magazi, koma kugwiritsidwa ntchito mosamalitsa kumafuna fupa la mafupa ndi aspirate ndi mayesero ena.
Zotsatira
Krumsiek J, Marr C, Schroeder T, et al. Kusiyana kwa Hierarchical kwa Myeloid Progenitors Kunyoreswa mu Network Transform Factor Network. PLoS One. 2011; 6 (8): e22649.
Eaves CJ. Maselo amtundu wa Hematopoietic: malingaliro, matanthauzo, ndi zatsopano. Magazi . 2015; 125 (17): 2605-2613.
Orkin SH, Zon LI. Hematopoiesis: Paradigm Yoyamba ya Biology Yamagulu Atsamba. Cell . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Development (Cambridge, England) . 2013; 140 (12): 2463-2467.
American Cancer Society. Kodi mthempha ya m'mitsempha yambiri imapezeka bwanji? Idapezeka mu December 2015.
Williams, L. "Kubwereza Kwambiri kwa Hematopoiesis ndi Immunology: Zotsatira za Omwe Amaloledwa Kutsegula Maselo a Hematopoietic" ku Ezzone, S. (2004) Kupanga Mafakitale Atsitsi Othandizira: Buku Lopereka Chithandizo cha Achipatala: Pittsburgh, PA (pp.1- 12).