Kafukufuku pa Njira Zapamwamba Zowonetsera Kanyama
Kubwezeretsedwa kwa khungu kumayeseranso kubwezeretsanso kanyumba kowonongeka kotchedwa articular (joint joint). Njira zingapo zakhala zikugwiritsidwanso ntchito kwa kukonzanso khungu . Ngakhale zina mwa izi zikugwiritsidwa ntchito lerolino, ochita kafukufuku akupitiriza kuyang'ana njira zatsopano zobweretsera kadoti pofuna kuyesa anthu kupumula ku ululu wa osteoarthritis.
Kodi Kasitoma Yotani?
Matendawa amapezeka ndi collagens, proteoglycans, ndi mapuloteni omwe si othandizira.
Ngakhale kanyumba kakang'ono kamangidwe kake, pafupifupi 85 peresenti ya karotila ndi madzi. Izi zimachepetsa pafupifupi 70% mwa anthu achikulire. Chondrocytes ndiwo maselo okhawo omwe amapezeka mu kakotila ndi zokololazo ndikusunga kanyumba kake.
Katemera wotchedwa articular cartilage amathandiza kuti azigwiritsira ntchito mankhwalawa. Zimatero chifukwa zimathera mapeto a mafupa awiri omwe amapanga mgwirizano. Kuwonongeka kwa karoti kungayambidwe ndi zinthu zingapo kuphatikizapo:
Amagulu okhudzidwa ndi karotila akuwonongeka amakhala opweteka, ouma, ndi osowa pang'ono.
Vuto ndiloti katemera sangathe kudzichiritsa. Chifukwa cha zimenezi, akatswiri ambiri ofufuza ochita kafukufuku ndi omwe akuyesetsa kuti akwanitse kukula katemera watsopano ndi kuziika m'malo mwa chotupa kapena chotupa.
Kupita Patsogolo Ndi Kukhazikitsidwa Kwambiri kwa Cartilage
Njira zambiri zakhala zikukonzekera zomwe zikuwonetseratu kupita patsogolo kwa kagaweta.
- Kusakanizidwa kapena Abrasion - Dokotala wochita opaleshoni amachotsa khungu lotayirira lomwe limayambitsa magazi pamphuno ndi kukula kwa fibrocartilage (fibrous cartilage kapena minofu yofiira ). Nthaŵi zina, fibrocartilage ikhoza kukhala yamphamvu kwambiri kuti muteteze mwakachetechete.
- Kusakaniza kwapang'onopang'ono - Dokotala wochita opaleshoni amachotsa malo okhudzidwawo ndipo amachititsa kuti pang'onopang'ono pangidwe. Izi zapangidwa kuti zithandize kukhetsa magazi komanso kukula kwa fibrocartilage.
- Kupanga Opaleshoni ya Mosaicplasty kapena Osteochondral Autograft Surgery - Achipatala amachotsa phungulo la fupa ndi katoloti wophimba kuchokera kumtunda wothandizana nawo ndikuiika pamalo owonongeka.
- Periosteal Flap - Dokotala wa opaleshoni amachotsa gawo la periosteum ( minofu yothandizira mafupa onse) kuchokera ku zitsulo ndikuiika kumalo owonongeka kwa kanyumba .
- Autologous Chondrocyte Implantation (ACI) - Dokotala wochita opaleshoni amachotsa kachilombo kakang'ono ka bondo. Minofu imatumizidwa ku labu yomwe iyenera kukonzedwa. Kuchita opaleshoni yachiwiri kumafunika kuti maselo akuluakulu apangidwe apangidwe pamalo a karoti yowonongeka.
- Osteochondral Allografts - Fupa la wopereka limagwiritsidwa ntchito kukonzanso kanyumba kowonongeka.
- Matrix Associated Chondrocyte Implantation (MACI) - The FDA inavomereza njira iyi mu 2017 yogwiritsidwa ntchito kwa anthu oposa 55 ndi "zolakwika za chondral" - zotupa zomwe zingayambitse osteoarthritis wa bondo. Ndi ofanana ndi ACI koma imafuna opaleshoni yochepa kwambiri ndipo ma chondrocytes amatumizidwa kwa dokotala wa opaleshoni pa chigamba chomwe chimakhala ngati chowombera pa malo owonongeka.
Zonsezi zimapereka zotsatira zosakaniza. Palinso mafunso ambiri omwe amachititsa kuti ayambe kukonzanso khungu.
Zovuta zambiri zachipatala zimayesedwa kuti mupeze mayankho ogwira mtima ndikukhazikitsa njira zothetsera zizindikiro za matenda a nyamakazi ndikupanga malo okwanira kwa karoti yowonongeka.
Kafukufuku Akupitirizabe
Akatswiri ambiri ofufuza akuganiza kuti vuto loti athetse vuto la kukonzanso karoti. Padziko lonse lapansi, kufufuza ndi njira zatsopano zimapitilira kuyang'ana nkhaniyi ndipo zotsatira zoyambirira zimawoneka zabwino.
Mwachitsanzo, mu 2008, akatswiri a sayansi ya zakuthambo ku Rice University adapeza kuti kupsyinjika kwakukulu (kofanana ndi komwe kunapezeka mamita mailosi pansi pa nyanja) kumapangitsa maselo a khunyu kukula minofu yatsopano.
Minofu yatsopanoyi ili ndi pafupifupi zinthu zonse zakutchire.
Ofufuzawo amakhulupirira kuti chitukukochi chimakhala ndi lonjezo la mankhwala a nyamakazi. Wofufuza wotsogolera anachenjezeratu kuti padzakhala zaka zingapo kuti ndondomekoyi ikhale yokonzeka kuyesedwa kwachipatala mwa anthu.
Maselo amathithi akugwiritsidwanso ntchito kukula msanganizo watsopano kumapiko a nyamakazi pogwiritsa ntchito njira ku Washington University School of Medicine mu 2017. Pogwirizana ndi Cytex Therapeutics, chiyembekezo cha ochita kafukufukuwa ndi chakuti izi zidzakhala njira yotsatizira opaleshoni yopatsirana .
Njirayi imapereka lonjezo la anthu omwe ali ndi zaka zopitirira 50. Zimagwiritsira ntchito "3-D, zowonongeka zowonongeka" ndipo zimayambanso kulumikizana ndi chiuno kuti athetse ululu. Kwa odwala nyamakazi, amatha kuchepetsa, kapena osachotsa, kufunika kwa chiuno chatsopano.
Zotsatira
- Axtell B. FDA OKs Choyamba mu Mbadwo Watsopano wa Kukonza Kanyama Kwambiri. Arthritis Foundation. 2017.
- Boyd J. Cartilage kusinthika '20, 000 Leagues Under the Sea '. Rice University. 2008.
- Dryden J. Stem Maselo Amagwiritsidwa Ntchito Kukula Kanyama Kasinthasintha, Kumenyana ndi Kutupa. Sukulu ya Yunivesite ya Washington. 2016.
- > Chipatala cha Opaleshoni Yapadera. Ndondomeko Zowonongeka Nkhosa Zowonongeka Zowonongeka Onetsani Lonjezo Podzudzula Odwala Oposa 40. 2016.
- > Rai V, > Dilissio > MF, Dietz NE, Agrawal DK. Njira Zatsopano Zowonongeka Mankhwala: Kukonzekera Mwatsatanetsatane wa Scaffold Development and Engineering Tissue Engineering. Journal of Research Biomedical Research Part A. 2017. do: 10.1002 / jbm.a.36087.