Pennsaid ndi ndondomeko ya NSAID yowonjezera yomwe idalandira chivomerezo cha FDA pa November 4, 2009, kuti imve kupweteka ndi zizindikiro zogwiritsidwa ntchito ndi mafupa a bondo . Dzina lopangidwa ndi Pennsaid ndi diclofenac sodium. Pennsaid inakhazikitsidwa ndi Nuvo Research Inc. Iyi ndi diclofenac, yomwe imapezeka ngati mapiritsi.
Kodi Pennsaid Imagwira Ntchito Bwanji?
Mankhwala osagwiritsa ntchito mankhwala osakanizika (NSAIDs) amagwira ntchito mofanana.
Zimaletsa cyclooxygenase, ndi enzyme yomwe imayambitsa kupanga prostaglandin, yomwe imathandiza kwambiri kutukusira. Poletsa tizilombo toyambitsa matenda, ma NSAID amachititsa kuchepa kwa prostaglandins kotero kuti kutentha pang'ono. Tsoka ilo, prostaglandins imathandiza kwambiri ntchito zina za thupi, ndipo motero NSAID zimakhala ndi zotsatira zovuta. Momwemonso, prostaglandins ndizofunikira kwambiri popanga chiwalo cha m'mimba chomwe chili chofunika kwambiri poteteza mimba m'mimba. NSAID, mwa kuchepetsa prostaglandin, zomwe zimayambitsa kuwonongeka kwa chotchinga chotetezera ichi ndipo zingayambitse kupweteka m'mimba ndi zilonda.
Chiphunzitso chogwiritsira ntchito mapulogalamu a NSAIDs ndikuti kugwiritsa ntchito mankhwalawa kumachepetsa kuchepa, komanso kumachepetsanso kuchepa kwa malo ogwiritsira ntchito, koma mankhwalawa sangafike pamtunda wokwanira wa magazi kuti athe kuwononga zotsatira zake. monga zilonda zakumimba.
Ndipotu, kafukufuku wasonyeza kuti pogwiritsira ntchito mapepala a NSAID machitidwe a mankhwalawa ndi pafupifupi 5 peresenti ya zomwe zili mkati mwa mankhwala omwe mankhwalawa amagwiritsidwa ntchito.
Zotsatira Zoipa Zofanana ndi Mlomo NSAIDs
Kugwiritsiridwa ntchito kwa NSAID zamtunduwu pochizira mafupa a m'magazi kumapereka mwayi waukulu wokhudzana ndi chitetezo kwa odwala ena.
Njira yothandizira mapindu awa monga momwe tafotokozera pamwambapa. Chithandizo chamtunduwu chingakhale chosavuta komanso chokhalitsa poyerekeza ndi NSAID zamlomo.
Zomwe zingathetse mavuto monga zilonda , m'mimba m'magazi , ndi matenda a mtima zilipo koma zimakhala zochepa poyerekeza ndi mapiritsi a mankhwala awa.
Zotsatira zofala kwambiri zomwe zimagwirizanitsidwa ndi Pennsaid ndi kufota pang'ono kapena kukwiya komwe kumagwiritsidwa ntchito.
Kodi Zimagwira Ntchito?
Kupenda kwaposachedwa komwe kwachitidwa ndi Cochrane Cooperation kunawunika maphunziro 61 omwe adafufuzira ngati NSAID zapamwamba zimagwira ntchito. Mwachidule, yankho ndilo inde. Pogwiritsa ntchito deta kuchokera ku maphunziro onse, anthu pafupifupi 75% adapeza mpumulo waukulu wa kupweteka kwa minofu / mapiritsi (kutonthozedwa kwakukulu kumatanthauza kupweteka kwa hafu ndi theka) pamene mukugwiritsa ntchito diclofenac zamatsenga, izi ndi zosiyana ndi pafupifupi 50% analandira placebo.
Zotsatira:
Cochrane Review of Topical NSAIDs
> http://www.cochrane.org/CD007402/SYMPT_topical-non-steroidal-anti-inflammatory-drugs-for-acute-musculoskeletal-pain-in-adults
FDA ikuvomereza Pennsaid. Drugs.com.
http://www.drugs.com/newdrugs/fda-approves-pennsaid-topical-solution-1758.html
Pennsaid. NUVO