Kodi UCTD Imasiyana Bwanji ndi MCTD?
Matenda osokoneza bongo (UCTD) ndi ophatikizapo minofu (MCTD) ndizo zikhalidwe zomwe zimakhala zofanana ndi zina zomwe zimayambitsa matenda, koma pali kusiyana komwe kumawapangitsa kukhala osiyana. Mu matenda osokoneza thupi, thupi lonse limakhudzidwa ndipo chitetezo cha mthupi , chomwe chimateteza thupi mwa kuwukira othawa achilendo, zimayambitsa ziwalo za thupi.
Mu matenda amodzimodzi, monga dzina limatanthawuzira, minofu yodzigwirizanitsa ikugwedezeka ndipo ikukhudzidwa. Minofu yothandizira imathandizira komanso imagwirizanitsa mbali zosiyanasiyana za thupi ndikuphatikizapo khungu, kadoti, ndi zina.
Matenda osokoneza bongo ndi matenda omwe amachititsa munthu kukhala ndi matenda enaake omwe amachititsa kuti tizirombo toyambitsa matenda - systemic lupus erythematosus , scleroderma , ndi polymyositis. Nthawi zina amatchedwa syndrome. M'malo mwake, matenda osagwiritsidwa ntchito osagwidwa ndi matenda Matendawa alibe zinthu zokwanira kapena zofunikira kuti zikhale zozizwitsa monga zozizwitsa zomwe zimayambitsa matenda.
Zizindikiro za Matenda Osakanikirana Osalumikizidwa
Odwala omwe ali ndi matenda osokoneza ubongo amakhala ndi zizindikiro (mwachitsanzo, kupweteka pamodzi), zotsatira za labata (mwachitsanzo, zabwino za ANA ), kapena zizindikiro zina za matenda osokoneza bongo, koma samakhutitsa chiwerengero cha matenda omwe amagwiritsa ntchito, monga lupus , nyamakazi ya nyamakazi , matenda a Sjogren , scleroderma, kapena ena.
Ngati pali zifukwa zosakwanira kuti zikhale ngati matenda amodzi, zimakhala ngati "undifferentiated". Matanthauzo a matenda osakanikirana omwe amayamba kugwiritsidwa ntchito anayamba kuchitika m'ma 1980. Kwenikweni, ilo linagwiritsidwa ntchito kwa odwala amene ankaganiziridwa kuti ali pachiyambi cha matenda okhudzana ndi matenda.
Mapeto a lupus ndi opanda lupus erythematosus anali maina ena ogwiritsidwa ntchito pofotokoza gulu la odwalawa.
Iwo amaganiza kuti 20% kapena ocheperapo omwe ali ndi matenda osagwirizana ndi minofu amapita patsogolo kuti azindikire kuti ali ndi matenda opatsirana. Pafupifupi gawo limodzi mwa magawo atatu aliwonse amapita ku chikhululukiro, ndipo ena onse amakhala ndi vuto lopanda matenda.
Matenda a nyamakazi, arthralgia, Raynaud's phenomenon , leukopenia (chiwerengero chochepa cha maselo oyera), mitsempha, alopecia, zilonda zakumlomo, maso owuma, pakamwa youma, kutentha kwa malungo, ndi photosensitivity. Kawirikawiri, palibe kugonana kwa mtima kapena impso, kapena kuloĊµerera kwa chiwindi, mapapo, kapena ubongo. Ambiri mwa odwala omwe ali ndi matenda osokoneza ubongo, mwina 80%, ali ndi mbiri yowonongeka ya autoantibody, nthawi zambiri anti-Ro kapena anti-RNP autoantibodies.
Kuzindikira ndi Kuchitira UCTD
Monga gawo la njira yothandizira matenda osokoneza ubongo, mbiri yakale ya zamankhwala, kufufuza thupi, ndi kuyesa kwa ma laboratory ndikofunika kuti pasakhale matenda ena a nthendayi. Ponena za chithandizo cha matenda osokoneza ubongo, palibe pulogalamu ya sayansi yeniyeni yothandizira mankhwala osokoneza bongo.
Kusankhidwa kwa mankhwalawa kumakhala kochokera pa zizindikiro zomwe zidaperekedwa komanso kupambana kwa dokotala kale polemba chithandizo china cha matenda a rheumatic.
Kawirikawiri, chithandizo cha UCTD chimaphatikizapo kuphatikizapo mankhwalawa ndi ma NSAID kuti amve kupweteka, minofu ya corticosteroids ya khungu ndi minofu, ndi Plaquenil (hydroxychloroquine) ngati mankhwala osokoneza bongo (DMARD). Ngati yankho liri lokwanira, mankhwala ochepa a mankhwala a prednisone amatha kuwonjezeka kwa kanthawi kochepa. Mankhwala akuluakulu a corticosteroids, mankhwala a cytotoxic (mwachitsanzo, Cytoxan), kapena DMARDS zina (monga Imuran) sagwiritsidwa ntchito.
Methotrexate ikhoza kukhala njira yothetsera vuto lopweteka kwambiri la matenda osokoneza bongo.
Mfundo Yofunika Kwambiri
Chizindikiro cha matenda osokoneza ubongo ndi osangalatsa kwambiri. Pali chiopsezo chochepa cha kupita patsogolo ku matenda omwe amagwiritsidwa ntchito bwino, makamaka pakati pa odwala omwe sasintha matenda osokoneza bongo omwe amatha zaka 5 kapena kuposerapo. Ambiri amakhalabe ofatsa ndipo zizindikiro zimachiritsidwa popanda kusowa kwa ntchito zolimbitsa thupi.
Zotsatira:
Matenda Osokoneza Matenda (UCTD). Mosca M. et al. Zomwe Zidasinthidwe. 2006 Nov; 6 (1) 1-4. http://www.ncbi.nlm.nih.gov/pubmed/17110308
Matenda Osakanikirana a Matenda Aakulu - Mwachidule. Jessica R. Berman, MD. Chipatala cha Opaleshoni Yapadera. 11/10/2009. Chilombo