Mankhwala osokoneza bongo amachititsa kuti anti-inflammatory effect mu matenda a rheumatic
Mankhwala a cytotoxic omwe amagwiritsidwa ntchito pochizira matenda opatsirana ndi awa:
- Azathioprine (Imuran)
- Cyclophosphamide (Cytoxan)
- Methotrexate (Rheumatrex kapena Trexall)
Mankhwala awa anali kutchedwa "cytotoxic" chifukwa amachiza matendawa mwa kupha maselo am'thupi. Kukhoza kwawo kuthandizira zizindikiro za matenda ena, monga matenda a rhumum , lupus ndi vasculitis , komabe, zimakhala chifukwa cha zotsutsana ndi zotupa zawo kusiyana ndi mphamvu zawo zakupha maselo.
Ndipotu, mlingo wochepa wa methotrexate wothandizira kuti izi zitheke kwenikweni zimatsutsana ndi kutupa komanso si cytotoxic.
Ubwino ndi Ngozi za mankhwala a Cytotoxic for Rheumatic Diseases
Cytoxan
Mwa mankhwala atatuwa, Cytoxan imakhala ndi zotsatira zovuta kwambiri ndipo nthawi zambiri imatha kuchepetsa matenda oopsa a lupus, vasculitis, kapena mapapu amene nthaŵi zina amapezeka ndi matenda a nyamakazi, nyamakazi, ndi scleroderma .
Chodetsa nkhaŵa chachikulu ndi Cytoxan ndi chiopsezo cha kupwetekedwa kwa mafupa a mafupa omwe angapangitse chiopsezo chotenga kachilomboka kapena kutuluka m'magazi. Kuonjezerapo, pali chiwopsezo chochepa koma chotsimikizika cha khansa yokhudza khungu ndi chikhodzodzo. Odwala ena akhoza kukhala ndi vuto lopweteka kwambiri lotchedwa interstitial cystitis. Ngati mankhwalawa atchulidwa pamlomo, kumwa madzi mobwerezabwereza ndi kukodza kungathandize kupewa vutoli. Cytoxan kawirikawiri imaperekedwa ndi kugwidwa mwakachetechete kamodzi komwe kungathandizenso.
Mankhwalawa ndi otopetsa (angayambitse vuto la kubadwa ngati atengedwa panthawi ya mimba) ndipo ayenera kupeŵa mwa amayi omwe sagwiritsa ntchito njira zoyenera kubereka kapena omwe angakhale ndi pakati. Pomaliza, pangakhale chiopsezo chowonjezereka cha matenda aakulu ndi ntchito ya Cytoxan.
Imuran
Imuran ndi yovomerezedwa ndi FDA kuti ikhale ndi matenda a nyamakazi ndipo imagwiritsidwa ntchito pochiza matenda a lupus ndi matenda ena.
Amagwirizananso ndi chiopsezo cha kupwetekedwa kwa mafupa a mitsempha ndipo akhoza kuwonjezera kowopsa kwa khansa zina. Pali chiopsezo chowonjezereka chokhala ndi kachilombo koopsa pamene mutenga mankhwalawa.
Methotrexate
Methotrexate ndi ya FDA yomwe imavomereza matenda a nyamakazi ndipo ikhoza kuthandizanso pa matenda ena omwe amagwiritsidwa ntchito monga lupus, myositis, ndi vasculitis.
Ngakhale methotrexate ingakhale ndi zotsatira zofanana monga mankhwala ena awiri, zikuwoneka kuti ali ndi mbiri yabwino ya chitetezo. Mofananamo ndi Cytoxan, ndizovomerezeka komanso siziyenera kugwiritsidwa ntchito ndi amayi ndi abwenzi awo ngati sakugwiritsa ntchito njira zoyenera kubereka kapena ali ndi mwayi woyembekezera.
Kuonjezera apo, mankhwalawa amagwiritsidwa ntchito ndi chiopsezo chochepa cha matenda a m'mapapo (osagwiritsidwa ntchito pneumonitis) omwe angawopsyeze moyo ngati wodwalayo sakuletsa mankhwalawo ndikuchiritsidwa. Kawirikawiri, zizindikiro za vutoli zimaphatikizapo kupuma pang'ono, chifuwa chouma, ndi malungo. Monga mankhwala ena awiri, pangakhale ngozi yowonjezera ya matenda aakulu.