Zizindikiro, Kuzindikira, ndi Njira Zothandizira Lymphoplasmacytic Lymphoma
Kodi ndi macroglobulinemia ya Waldenstrom ndi chiyani chomwe mukufuna kudziwa ngati muli ndi matendawa?
Waldenstrom Macroglobulinemia - Tanthauzo
Waldenstrom macroglobulinemia (WM) ndi mtundu wamba wosakhala wa Hodgkin lymphoma (NHL) . WM ndi khansara yomwe imakhudza ma lymphocyte B (kapena maselo a B) ndipo imadziwika kuti ndi operewera kwambiri kwa mapuloteni otchedwa IgM antibodies.
WM angathenso kutchulidwa kuti Macroglobulinemia, primary macroglobulinemia, kapena lymphoplasmacytic lymphoma.
Mu WM, khansara yosaoneka bwino imapezeka mu ma lymphocyte B musanafike pokhala maselo a plasma. Maselo a plasma ali ndi udindo wopanga mapuloteni oteteza tizilombo toyambitsa matenda. Choncho, chiwerengero chowonjezeka cha maselo amenewa chimapangitsa kuchulukitsa kuchuluka kwa wodwala wodwala, IgM.
Zizindikiro ndi Zizindikiro za WM
WM ingakhudze thupi lanu m'njira ziwiri.
Msuzi wa mafupa ukuwombera. Maselo a lymphoma angakulepheretseni mafupa anu, zomwe zimachititsa kuti thupi lanu likhale lopanda manambala okwanira, maselo ofiira a magazi, ndi maselo oyera . Chotsatira chake, kuchepa kumeneku kudzachititsa zizindikiro ndi zizindikiro zomwe zimakhala zochepa m'thupi la magazi, thrombocytopenia (count low platelet count), ndi neutropenia (kuchepa kwa neutrophil - neutrophils ndi mtundu umodzi wa selo loyera la magazi) . Zina mwa zizindikirozi zingakhalepo:
- Kutuluka kwachilendo kapena kosazolowereka, monga kutaya magazi, zilonda zachilendo, kapena nosebleeds
- Kumva kutopa modabwitsa, ngakhale kuti mukugona mokwanira
- Kupuma pang'ono ndi kulimbikira kulikonse
- Matenda obwerezabwereza kapena matenda omwe simukuwoneka kuti sakulimbana nawo
- Khungu lenileni
Chidziwitso . Kuphatikiza pa zotsatira zake pa fupa la fupa, kuchuluka kwa mapuloteni a IgM m'magazi anu kungayambitse chomwe chimatchedwa kudziletsa.
Mwachidule, kudzipatula kumatanthawuza kuti mwazi umakhala wandiweyani kapena gooey ndipo ukhoza kukhala ndi zovuta kuyenda mosavuta kudzera mu mitsempha yako. Chidziwitso chimayambitsa zizindikiro zina zosiyana zomwe zimaphatikizapo:
- Zosintha m'masomphenya, monga blurriness kapena kupitirira kwa masomphenya
- Kusintha kwa maganizo m'maganizo, monga chisokonezo
- Chizungulire
- Mutu
- Kunjenjemera kapena kugwedeza kumapazi kapena manja
Mofanana ndi mitundu ina ya lymphoma, maselo a khansa angakhalepo m'madera ena a thupi, makamaka m'matumbo ndi chiwindi, ndipo amachititsa ululu. Kutupa kwa ma lymph nodes kungakhalensopo.
Muyenera kukumbukira kuti zizindikirozi zikhoza kukhala zonyenga ndipo zingakhalepo muzinthu zina zambiri zochepa. Ngati muli ndi nkhawa za kusintha kwa thanzi lanu, nthawi zonse ndi bwino kukaonana ndi dokotala kapena wothandizira zaumoyo.
Nchiyani Chimachititsa WM?
Monga momwe ziliri ndi mitundu yambiri ya khansa, sizikudziwika chomwe chimayambitsa WM. Komabe, ofufuza apeza zinthu zina zomwe zimawoneka ngati zofala kwa anthu omwe ali ndi matendawa. Zizindikiro zomwe zimadziwika ndi izi:
- Ali ndi zaka zoposa 60
- Mbiri ya chikhalidwe chomwe chimatchedwa monoclonal gammopathy ya tanthauzo losadziŵika (MGUS)
- Mbiri ya WM m'banja lawo
- Kukhala ndi kachilombo koyambitsa matenda a hepatitis C
Kuonjezera apo, WM imawoneka mwa amuna nthawi zambiri kuposa akazi, komanso anthu a ku Caucasus nthawi zambiri kuposa African American.
Kuzindikira WM
Mofanana ndi mitundu ina ya magazi ndi khansa ya mongo, WM nthawi zambiri amapezeka kuti akuyesa magazi ndi fupa la mafupa ndi aspirate .
Kuwerengera kwa magazi kumatha kuchepetsa chiwerengero cha maselo achibadwa a magazi, monga maselo ofiira, mapiritsi, ndi maselo oyera. Kuwonjezera apo, kuyesera kwa magazi kudzawonetsa kuwonjezeka kwa kuchuluka kwa mapuloteni a IgM.
Mafupa a mafupa ndi aspirate adzafotokoza zambiri za mitundu ya maselo mumtambo, ndikuthandizani dokotala kusiyanitsa WM ndi mitundu ina ya lymphoma.
Kodi WM Amachitiridwa Motani?
WM ndi mtundu wodabwitsa kwambiri wa khansara, ndipo ofufuza ali ndi njira yochuluka yophunzirira za njira zosiyana zothandizira zomwe zilipo, ndi momwe amaziyerekeza ndi wina ndi mzake malinga ndi momwe angagwiritsire ntchito. Chotsatira chake, anthu omwe angoyamba kumene kuti ali ndi WM angasankhe kutenga nawo mbali m'mayesero a kachipatala kuthandiza asayansi kuti amvetse zambiri zokhudza vutoli.
Palibe chithandizo chodziwika kwa WM panthawiyi, koma pali njira zambiri zomwe zasonyeza bwino kupambana matendawa.
- Plasmapheresis: Mankhwala osapitirira malire a IgM m'magazi angayambitse magazi kapena kutayika kwa magazi. Mwazi wandiweyani ukhoza kukhala kovuta kuti zakudya ndi mpweya uziperekedwa kwa maselo onse a thupi. Kuchotsa zina mwa IgM kuchokera m'magazi kungathandize kuchepetsa kulemera kwake kwa magazi. Pa plasmapheresis , magazi a wodwalayo amalembedwa pang'onopang'ono kudzera mu makina omwe amachotsa IgM ndikubwerera mthupi lawo.
- Chemotherapy ndi Biotherapy: Odwala omwe ali ndi WM amachiritsidwa ndi chemotherapy. Pali mankhwala osiyanasiyana omwe angagwiritsidwe ntchito. Zina mwa izi ndi kuphatikiza Cytoxan (cyclophosphamide) ndi Rituxan (rituximab) ndi dexamethasone, kapena Velcade (bortezomib) kuphatikizapo Rituxan ndi dexamethasone. Pali mankhwala ena ambiri komanso mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza WM zonse muzochita komanso m'mayesero a zachipatala.
- Kujambula Maselo Atsamba: Sikudziwika kuti ntchito yothandizira maselo otetezeka adzagwira ntchito yotani WM. Mwamwayi, ukalamba wa odwala ambiri a WM amachepetsa kugwiritsa ntchito mankhwala opha thupi, omwe angathe kukhala ndi zotsatira zoopsa za poizoni, koma kuika kwazidzidzidzi pamatsatira mankhwala apamwamba kwambiri amatha kukhala oyenera komanso ogwira mtima, makamaka omwe amadwala matendawa .
- Splenectomy: Monga mitundu ina ya NHL, odwala omwe ali ndi WM angakhale ndi nthenda yotukulidwa, kapena splenomegaly. Izi zimayambitsidwa ndi kumanga ma lymphocytes mu nthata. Kwa odwala ena, kuchotsedwa kwa mpeni, kapena splenectomy, angapereke kukhululukidwa kwa WM.
- Yang'anani ndikudikira: Mpakana WM ikuyambitsa mavuto, madokotala ambiri adzasankha njira yopita kuchipatala. Pachifukwa ichi, mupitiriza kuyang'anitsitsa ndi katswiri wanu ndikuzengereza mankhwala achiwawa (ndi zotsatira zowonjezereka) kufikira mutakhala ndizofunikira. Ngakhale zingakhale zovuta kulingalira kupitiliza moyo wanu wa tsiku ndi tsiku ndi khansa m'thupi lanu Osagwira ntchito pa izo, kafukufuku wasonyeza kuti odwala omwe amachedwa kuchepetsa matendawa mpaka atayamba kukhala ndi zovuta kuchokera kwa iwo alibe zotsatira zoipitsitsa kuposa anthu omwe ayamba kumwa mankhwala nthawi yomweyo.
Kuwongolera Iwo
Waldenstrom macroglobulinemia, kapena WM, ndi mtundu wochepa kwambiri wa NHL umene umapezeka mwa anthu pafupifupi 1,500 pachaka ku US. Ndi khansara yomwe imakhudza ma lymphocyte B ndipo imayambitsa kuchuluka kwachilendo kwa IgM ya anti-antibody m'magazi.
Chifukwa chakuti si zachilendo, komanso chifukwa chakuti timadziwa zambiri za lymphoma, pakalipano palibenso njira imodzi yothandizira ya WM. Choncho, odwala ambiri omwe amapezeka kumene ali ndi WM akulimbikitsidwa kutenga nawo mbali m'mayesero a kachipatala kuti athandizire asayansi kudziwa zambiri za khansa yachilendo yodetsa magazi, ndipo akuyembekeza kuti adzakhala ndi mwayi wogwiritsa ntchito mankhwala omwe tsopano adzakhala oyenera mu tsogolo.
Zotsatira
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