Kulimbana Kwambiri ndi Matenda a Parkinson
Kusintha kwa dopamine monga mankhwala a carbidopa / levodopa ndi imodzi mwa mankhwala opangidwa bwino kwambiri m'maganizo a anthu ndipo imalola odwala matenda a Parkinson kuti athetse chitetezo chawo. Komabe, nthawi zina, dopamine m'malo mwake amakhala ndi zotsatira. Zomwe zimadziwika bwino kwambiri ndizoziphatikiza (kuthamangitsidwa kwambiri) kapena zokopa.
Dopamine dysregulation syndrome (DDS) ndi vuto lina lomwe lingatheke, lomwe limapezeka pafupifupi 4 peresenti ya odwala pa dopaminergic therapy.
Zizindikiro za Dopamine Dysregulation Syndrome
Chizindikiro chofala kwambiri cha dopamine dysregulation ndi chokhumba chokhumba cha mankhwala a Parkinson monga carbidopa / levodopa . Ngakhale ngati palibe zizindikiro (monga kutenthedwa kapena kugwedezeka), wodwalayo angamve kuti akusowa mankhwala. Ena akhoza kuyesa zizindikiro zawo za Parkinsonian kapena chiphuphu abwenzi kapena achibale kuti apeze mankhwala omwe akufunidwa - izi ndizomene chilakolakocho chiri champhamvu.
Kuphatikizanso apo, anthu omwe ali ndi matenda a dopamine dysregulation angamve ngati akuphwanyidwa kapena apamwamba, ndipo popanda mankhwala, amamva kuti akuvutika maganizo kapena akutopa. Komanso, mavuto odzitetezera, monga kukakamizidwa kutchova njuga kapena kugula, matenda odyera kapena makhalidwe ena oledzera, angayambe, chifukwa cha dopamine dysregulation.
Zizoloŵezi zophweka zosavuta, monga kusonkhanitsa zinthu kapena zinthu zopanda malire mu mzere, zikhoza kuwonekera. Zizindikiro zoopsa monga psychosis ndizotheka mu matendawa
Kodi Chimachititsa Bwanji Dopamine Dysregulation Syndrome?
Dopamine ikugwirizana ndi dongosolo lathu la mphotho pansi pa lobes loyambirira, kuphatikizapo ventral tegmental dera .
Ndipotu, mankhwala osokoneza bongo, monga cocaine, amachititsa kuti dopamine amasulidwe m'dera lino. Zochitika za dopamine m'dera lino la ubongo zakhulupirira kuti zimayambitsa matenda a dopamine dysregulation. Izi zikunenedwa, njira zeniyeni sizikumveka bwino. Kuwonjezera pamenepo, ngati dopamine ndi yofunika kwambiri ku kayendetsedwe kake komanso mphotho, mwina ndizodabwitsa kuti DDS si yachilendo.
Ngati mankhwala osokoneza bongo aperekedwa, mphotho ya mphotho ikhoza kukhala yowonjezera mphotho, zomwe zimafuna zambiri kuti zitheke. Tikudziwa kuti izi ndi zoona ndi mankhwala a dopamine ku Parkinson - madokotala akuluakulu amafunika kuwunikira kuti adziwe zomwezo. Ngakhale zina mwazifukwazi zikuchitika chifukwa cha matenda, asayansi ena amafunsa ngati chofunikachi chikhoza kuwonetsa mtundu wa chizoloŵezi, chomwe chimapereka mphoto, chikhoza kukhala ndi chilakolako cha mtundu.
Ndani Amalandira Dopamine Dysregulation Syndrome?
Kulephera kwa DDS kumasonyeza kuti anthu ambiri ali otetezedwa ku matendawa, pamene ena akhoza kukhala ndi zifukwa zobweretsa vutoli. Amuna omwe ali ndi matenda oyambirira angakhale pachiopsezo chachikulu. Zotsatira zamakakamizo zam'mbuyomu, monga kugwiritsa ntchito mankhwala osokoneza bongo, ndi chimodzi mwa zifukwa zazikulu kwambiri.
Kodi Dopamine Dysregulation Syndrome Yachitidwa Bwanji?
Chifukwa chakuti odwala omwe ali ndi DDS amakhala ndi chizoloŵezi cha mankhwala omwe amafunikanso kuti agwire, mankhwala abwino amatenga mlingo woyenera wa dopamine kapena dopamine agonists (mankhwala omwe amachititsa dopamine receptors). Matendawa amachepetsedwa pamene mlingo wa mankhwala ukuchepetsedwa. Mofanana ndi zizoloŵezi zina, chithandizo chamagulu chidzafunika kuti atsimikizire kuti mankhwala amatengedwa monga momwe adayankhira ndikuyendetsa zinthu zina zosayenera. Nthawi zambiri, antipsychotics angakhale othandiza kuthetsa nkhanza kapena psychosis, ngakhale kuti kuwonjezeka kwa chiopsezo cha zizindikiro za matenda a Parkinson.
Pansi
Dopamine ndi khunyu kamene kamakhala kovuta kwambiri kamene kamakhudza kayendetsedwe ka thupi lathu, zolinga zathu, ndi dongosolo lathu la mphotho m'njira zomwe sitimamvetsetse, ngakhale tikuphunzira zambiri. Ngakhale vuto la dopamine dysregulation silofala kwa matenda a Parkinson, akhoza kuchitika, ndipo njira yabwino kwambiri yolowera ndi yomwe imayambanso ndi kuthandizidwa ndi dokotala, wothandizira, komanso / kapena okondedwa awo.
Zotsatira:
Cilia, R., et al. (2014). Matenda a Dopamine dysregulation m'kati mwa matenda a Parkinson: Kuchokera kuchipatala kumayendetsedwe ka ubongo ndi kulamulira kwa nthawi yaitali. Journal of Neurology, Neurosurgery, & Psychiatry , 85 (3): 311-8.
Evans, AH, Lees, AJ (August 2004). Matenda a Dopamine dysregulation mu matenda a Parkinson. Malingaliro Amakono mu Neurology , 17 (4): 393-8.
Lawrence, AD, Evans, AH, Lees, AJ (October 2003). Kugwiritsa ntchito mankhwala opatsirana pogwiritsa ntchito mankhwala a dopamine mu matenda a Parkinson: Lancet Neurology , 2 (10): 595-604.
Pezzella, FR, et al. (January 2005). Zovuta ndi zochitika zachipatala za hedonistic homeostatic kuwonongeka kwa matenda a Parkinson. "Mov. Disord 20 (1): 77-81.