Irritable Bowel Syndrome ndi Nervous System
Kulephera kugwira ntchito pakati pa ubongo ndi matumbo kungakhale kowonjezera ku matenda a m'mimba (IBS).
Matenda ena ndi osavuta kumva. Ngati muli ndi pakhosi , dokotala wanu atenga zitsanzo za m'kamwa mwanu ndikuyesa mayeso kuti muwone ngati muli ndi kachilombo ka strep. Khungu lodabwitsa la khungu lanu lingayesedwe kuti liwone ngati liri ndi khansa.
Tsoka ilo, IBS ili yosavuta. Mosiyana ndi matenda omwe amawoneka, kuti amvetse zomwe zikulakwika mu IBS, ofufuza apeza kuti akuyenera kuyang'ana kupyola matumbo ndi ku machitidwe ovuta oyankhulana omwe amagwirizanitsa matumbo ndi ubongo.
Kuyamikira kwambiri ntchito yomwe ikuchitika mderali, mungafunikire kukhala ndi digiri ya sayansi ya ubongo. Ngakhale popanda chiwerengero chotere, ndizothandiza kumvetsetsa kovuta kugwirizana pakati pa ubongo ndi matumbo ndi momwe izi zikukhudzira IBS.
Zamoyo Zopangira Zamoyo
Onani ngati zokambiranazi zili ndi belu kuchokera nthawi yomwe mumakhala m'kalasi ya sayansi ya sekondale. Kuyankhulana pakati pa ziwalo zonse za matupi athu kumachitika mwa kudutsa uthenga kuchokera ku mitsempha ya mitsempha. Pano pali kufotokozedwa kosavuta kwa njira zosiyanasiyana zomwe kuyankhulana uku kumachitika:
- Matenda a m'mitsempha (CNS): ubongo ndi msana
- Pulogalamu ya mitsempha ya phokoso (PNS): mitsempha ya mitsempha yomwe imadutsa pambali pa ubongo ndi msana.
Ndondomeko ya mitsempha yowonjezera imagawidwa magawo awiri:
- Ndondomeko yamanjenje yosautsa: yotsogolera kudziletsa mwadzidzidzi kwa minofu ndikuyang'ana ku zowawa zakunja.
- Mavitamini oterewa : oyang'anira magalimoto ndi mayankho a ziwalo za mkati ( viscera ).
Inic Nervous System
System enteric nervous (ENS) ndi mbali ya dongosolo lodzidzimitsa la mantha lomwe liri ndi udindo woyang'anira njira yakugaya. ENS imayendetsa motility (kusuntha kwa minofu), kutsekemera kwa madzi ndi madzi. ENS imayendetsa ntchito yochuluka yokha yomwe nthawi zina imapatsidwa dzina "ubongo waung'ono." Chifukwa cha kufotokoza uku, n'zosavuta kuona kuti kumvetsa momwe dongosolo la enteric limagwirira ntchito ndi lofunikira kuti amvetsetse chomwe chingachitike molakwika thupi ndi IBS.
Kumakwerero Otsika
Kuyankhulana ndi njira ziwiri pambali ya ubongo (pakatikati wamanjenje) ndi dongosolo la m'mimba (dongosolo la manjenje la enteric). Njira zovuta zimagwirizanitsa ubongo ndi matumbo ndi chidziwitso chikuyenda mobwerezabwereza. Kulumikizana kwapafupi kumeneku kumawonekeratu bwino pa momwe timayankhira kupsinjika (kuwonedwa koopsya), zomwe zimasonyeza kuti njira yovuta yolankhuliranayi inali yofunikira kwambiri kuti tipulumuke ngati zamoyo.
Ochita kafukufuku akupeza umboni wakuti kupweteka kumeneku kumapangitsa kupweteka kwa m'mimba , kudzimbidwa ndi / kapena kutsekula m'mimba zomwe ziri zizindikiro za IBS. Mitsempha m'matumbo omwe akukumana ndi mavuto ambiri angayambe kusintha mu ubongo.
Maganizo, malingaliro, ndi kuyambitsa mbali zina za ubongo zomwe zimakhudzana ndi nkhaŵa kapena kuukitsidwa zingayambitse mayankho otukumula. Kulephera kugwira ntchito kungapezenso njira zosiyanasiyana zomwe zimagwirizanitsa ubongo ndi matumbo. Mwachitsanzo, pali umboni wakuti kusagwira ntchito mosiyana ndi njira ziwiri zosiyana mu dongosolo lodzidzimitsa la magazi kumagwirizanitsidwa ndi chizindikiro cha kutsekula m'mimba mofanana ndi chizindikiro cha kudzimbidwa. Kawirikawiri, zimawoneka kuti kutayika kwa ubongo m'magulu a ubongo kumapangitsa kuti thupi likhale lopitiriza kukhala ndi homeostasis, dziko limene machitidwe onse akugwira ntchito bwino.
Udindo wa Serotonin
Biology yochulukirapo: Njira yomwe mzere umodzi wamagulu umalankhulira ndi wotsatira ndi kudzera mu mankhwala otchedwa neurotransmitters . Nthotransmitter yamtengo wapatali kwambiri yogwiritsira ntchito digestive ndi serotonin (5-HT). Akuti pafupifupi 95 peresenti ya serotonin m'thupi la munthu imapezeka m'magazi. Serotonin imaonedwa kuti ndi gawo lofunika kwambiri la kayankhulidwe pakati pa ubongo ndi matumbo. Serotonin amawoneka kuti amagwira nawo ntchito motility , kukhudzidwa , ndi kutseka kwa madzi. Kusunthika, kumva ululu komanso kuchuluka kwa madzi m'thumba - mukhoza kuona chifukwa chomwe serotonin yakhala ikuyendera kwa ofufuza a IBS.
Kusiyanasiyana kwapezeka m'magulu a serotonin pakati pa odwala omwe ali ndi matenda otsekula m'mimba ndi omwe ali ndi kudzimbidwa. Odwala otsegula m'mimba anali otsika kwambiri kuposa serotonin m'magazi awo atatha kudya, pamene odwala omwe anali ndi chibwibwi anali otsika kuposa serotonin. Kusiyanasiyana kumeneku kumayesetseratu kuyambitsa mankhwala omwe amachulukitsa kapena amachepetsa ma serotonin poyang'ana malo omwe amalandira ( 5-HT3 ndi 5-HT4) kuti athetse IBS. Pali mankhwala awiriwa, koma onsewa ali ndi malamulo oletsera ntchito zawo kuti athetse mavuto aakulu:
- Lotronex : choyimitsa 5-HT3 chochizira kutsekula m'mimba
- Zelnorm: L 5-HT4 yolimbikitsa kuchipatala
Bungwe la IBS lofufuza posachedwapa likuyang'ana gulu la mapuloteni otchedwa serotonin reuptake transporters (SERTs). SERTs ali ndi udindo wochotsa serotonin itatulutsidwa. Pali chiwonetsero china kuti pali kusiyana muchithunzi cha SERT pamene IBS kapena kutupa kulipo. Sukulu ina ya kuganiza ndikuti kupitirira kwa serotonin kumasokoneza njira ya homeostasis, motero kulepheretsa kuti chiwerengero cha m'mimba chisagwire bwino.
Chidziwitso ndi Mphamvu
Kodi mungamasulire bwanji chidziwitso chanu chatsopano kuti muthe kuyendetsa bwino IBS yanu? Mwachiwonetsero, mulibe mphamvu zogwira mwachindunji mazenera anu a serotonin. Komabe, pali mbali ziwiri zomwe zochita zanu zimakhudza mwachindunji kayendedwe ka ubongo pakati pa ubongo ndi matumbo.
Kupyolera mukugwiritsa ntchito masewera olimbitsa thupi , mungathe kugwira ntchito mwakhama kuti muthetse kuyankha kwapanikizika, komwe kusintha kwa matumbo kumabwera poyankha maganizo ndi maganizo. Mutha kuganiziranso momwe chimbudzi chimagwirira ntchito popangira zakudya zazikulu kapena zonenepa pakusankha zakudya. Pofuna kutsekula m'mimba, ndi bwino kudya zakudya zing'onozing'ono, komabe pofuna kudya, kudya kwakukulu kungakhale koyambitsa kuyambitsa thupi.
Kumvetsetsa kuti mavuto omwe ali mu IBS akuwonjezera njira yopitirira "m'mimba yovuta" ingakuthandizeni kukhazikitsa njira zosiyanasiyana zothetsera mavutowa.
> Zosowa
> Fukudo S. Kupsinjika maganizo ndi ululu wa m'mimba: Kuganizira za matenda opweteka a m'mimba. Ululu . 2013; 154. lembani: 10.1016 / j.pain.2013.09.008.
> Meerveld BG-V, Johnson AC, Grundy D. Maganizo a Masamba, ndi Ntchito. Bukhu la Zofufuza za Pharmacology . 2017. do: 10.1007 / 164_2016_118.
> Norton, W. & Drossman, D. "Symposium Summary Report" (2007) Zokhudza Matenda a Matenda 16: 4 -7.
> Oświęcimska J, Szymlak A, Roczniak W, Girczys-Połedniok K, Kwiecień J. Zatsopano zokhudzana ndi matenda a pathogenesis ndi chithandizo cha matenda opweteka. Kupititsa patsogolo mu sayansi ya zamankhwala . 2017; 62 (1): 17-30. lembani: 10.1016 / j.advms.2016.11.001.