Momwe vutoli likuyendera limakhudza zizindikiro zanu
Mwinamwake munayamba mwawonapo mgwirizano pakati pa IBS ndi nkhawa. Izi ziri ndi zambiri zokhudzana ndi momwe thupi lathu limayankhira kusintha kwa mkati kapena kunja. Kuyankha kwapanikizika, komwe kumatchedwanso kuti kulimbana-kapena-kuthawa, kumawoneka kuti kwatukuka kuti tithe kuchitapo kanthu pa zoopsya zomwe zingatipangitse kuti tikhale ndi mwayi wopulumuka.
Kusokonezeka maganizo ndi njira yovuta. Zimakhudza machitidwe athu amantha ndi mapulaneti ndipo amachititsa kusintha mu njira zosiyanasiyana za thupi, kuphatikizapo kuthamanga kwa magazi, kuthamanga kwa mtima, kuthamanga kwa minofu komanso kutsegula m'mimba. Ndi kusintha kwa ntchito zamagazi zomwe zimagwirizanitsa maganizo ndi IBS pamodzi.
Ubongo-Kutenga Connection
Poyang'ana kupsinjika yowoneka (kunja kapena mkati), mbali zosiyanasiyana za ubongo zimayamba kulankhulana, kuphatikizapo korttex, thalamus, ndi ubongo. Zimenezi zimayambitsa yankho pambali ziwiri zazikulu za thupi. Yoyamba ndi hypothalamic-pituitary-adrenal axis, zomwe zimapangitsa kuchulukana kwa mankhwala osokoneza bongo, makamaka mahomoni otchedwa cortisol. Njira yachiwiri ndiyo njira yowonongeka yamatenda , yomwe imatulutsa adrenaline (epinephrine) ndi noradrenaline (norepinephrine) yomwe imayambitsa matenda a mtima, minofu ndi kugaya.
Njira ziwiri izi zimakhudza kwambiri mitsempha ya mitsempha yomwe imapezeka m'mimba, yomwe imadziwika kuti system enteric nervous system. Njirayi, yomwe imayambira ndi zovuta zowonongeka, zotsatiridwa ndi ubongo, komanso zomwe zimapangitsa kuti zitsitsimutso zifike m'matumbo, zikuwonetseratu kufunika koyang'ana kukhumudwa poyesera kumvetsetsa zomwe zimawonetsa ngati zizindikiro za IBS.
Kusintha Kwaumunthu pa Kupsinjika Maganizo
Kusokonezeka maganizo kumayambitsa kusintha kwa thupi:
- Kuwonjezeka kwa mtima kumawonjezeka
- Kuchulukitsa kupuma
- Kuwonjezeka kwa minofu
- Kuletsa chitetezo cha mthupi
- Kutaya m'mimba kutaya
- Kuwonjezeka pa liwiro la colonic contractions
- Kupuma kwa minofu ya chikhodzodzo
Kafukufuku
Pofuna kupeza chithandizo choyenera cha zizindikiro za IBS, ofufuza akhala akufufuzira zinthu zosiyanasiyana zomwe zimamasulidwa panthawi yachisokonezo. Chinthu chimodzi chomwe chikuwoneka kuti chili ndi tanthauzo lalikulu mukumva kupanikizika ndi corticotropin-release-factor (CRF). CRF ndi banja la peptides (ma molekyulu omwe amagwirizana ndi amino acid) omwe amapezeka mu ubongo ndi m'matumbo. Mu ubongo, CRF receptors amapezeka m'madera okhudzana ndi chimbudzi, malingaliro ndi kayendedwe ka mantha. M'kati mwa matumbo, CRF amachita mkati mwa colon kuti yowonjezera chitetezo chamadzi ndi madzi, zimakhudza msinkhu wa contractions ( motility ), ndipo zimawoneka kuti ikugwirizana ndi zomwe zimapweteka m'mimba . Tikuyembekeza kuti kumvetsetsa bwino udindo wa CRF kudzawongolera kusintha kwa mankhwala omwe amayenera zizindikiro za IBS.
Zotsatira:
Benson, H. The Relaxation Response (2000). New York: HarperTorch.
Monnikes, H., et.al. "Kulimbana ndi zovuta m'mabvuto okhudza m'mimba. Umboni wosinthika chifukwa cha kupweteka kwa m'mimba motility komanso kukhudzidwa." Matenda a Digestive 2001 19: 201-211.
Mayer, EA, et.al. "Kupanikizika ndi Matenda a M'mimba" American Journal of Physiology-Mimba ndi Matenda a Chiwindi 2001 4: G519-G524.
Tache, Y. "Kupanikizika ndi Kutupa Kwambiri Kwambiri: Kutsegula Bukuli" Makhalidwe Ovomerezeka a Makhalidwe Abwino Okhudza Mimba. 2007.