Matenda otsekula m'mimba kwambiri (IBS-D) ndi zizindikiro zake za ululu wa m'mimba ndi kupunduka, ndipo nthawi zambiri, mitsempha yowonongeka, yotsegula m'mimba, ndi vuto losokoneza thanzi. Ngakhale kuli kochepa, pali mankhwala omwe angapangidwe pofuna kuyesa kuthetsa zizindikiro. Zina mwa mankhwalawa zakonzedwa mwachindunji kwa IBS-D, pamene zina zimagwiritsidwa ntchito kuthana ndi zizindikiro zina, ndipo zina zimagwiritsidwa ntchito m'njira yochotsera.
Pano mudzapeza mwachidule za mankhwala oyambirira omwe dokotala angakusankheni.
Mankhwala Osokoneza Bongo
Kwa anthu ambiri omwe ali ndi IBS-D, Imodium , mankhwala opatsirana pogonana ndi chinthu chomwe chimasungidwa pafupi. Imodium imatengedwa pamlomo ndipo nthawi zambiri imalekerera. Amagwira ntchito yotsekula m'mimba mwa kuchepetsa kuthamanga kwa m'mimba komanso kuchuluka kwa madzi m'matumbo akuluakulu. Izi zimabweretsa kufunika kochepa komanso firmer stool. Tsoka ilo, imodium saoneka kuti ili ndi zotsatira zambiri pothetsa ululu wamimba.
Mankhwala Olemba
Mankhwala otsatirawa alandira chivomerezo cha FDA chochiza IBS-D:
Xifaxan: Xifaxan (rifaximin) ndi antibiotic yomwe imagwira ntchito mosiyana ndi antibiotic yomwe mungadziwe. Xifaxan sichitha m'mimba ndipo chifukwa chake zochita zake zimaganiziridwa kuti zimachitika kumtunda.
Kugwiritsa ntchito Xifaxan monga chithandizo cha IBS-D kunachokera ku kafukufuku wotsimikizira kuti ubongo waing'ono wa m'mimba (SIBO) ukhoza kukhala wochititsa zizindikiro za IBS-D. Chifukwa mankhwalawa amagwira ntchito m'deralo, amavomerezedwa bwino ndipo alibe mabakiteriya m'matumbo akulu omwe maantibayotiki ena ali nawo.
Kufufuza kafukufuku, Xifaxan yathandiza kwambiri kuchepetsa kupweteka kwa m'mimba, kutsekula m'mimba komanso kuphulika.
Viberzi, Truberzi (Europe): Viberzi (eluxadoline) imagwira ntchito pamatope a opioid m'thupi lanu. Zilondazi zimayendetsa liwiro lakumimba, kutseka kwa madzi ndi zowawa. Viberzi amagwira ntchito m'deralo ndipo chifukwa chake zotsatira zake zimakhala zochepa. Viberzi imatchedwa "mankhwala olamulidwa" chifukwa pali chiopsezo kuti chikhoza kukhala chizoloŵezi. Mu kafukufuku wafukufuku, Viberzi yasonyezedwa kuti achepetse kutsekula m'mimba ndi zowawa m'mimba.
Antispasmodics / Anticholinergics
Mankhwala a Antispasmodic (anticholinergic) amatchulidwa kaŵirikaŵiri kuti athandize m'mimba kupweteka kwa m'mimba ndikuphwanya anthu omwe ali ndi IBS-D. Mankhwalawa amathandizira kuchepetsa matenda a neurotransmitter acetylcholine m'matope. Kupindula kwa mankhwalawa kwa IBS = D kumachokera ku kuchepetsa kutsekemera kwa ntchentche komanso kuchepa kwa m'mimba. Pali zina zowonjezera kafukufuku wothandizira kupweteka kwa antispasmodics kwa IBS. Antispasmodics omwe amaperekedwa kwa IBS ndi awa:
- Buscopan (Hyoscin chochepetseni)
Kudetsa nkhaŵa
Ngakhale kuti nthawi zambiri amalembedwa pofuna kuchiza matenda ovutika maganizo, nthawi zina amadandaulira chifukwa cha zotsatira zake za zizindikiro za IBS. Sizidziwike bwino chifukwa chake zotsatira zabwinozi zimachitika. Zikhoza kukhala chifukwa cha mankhwala omwe amakhala ndi zotsatira pa ziwalo za ubongo zomwe zimapezeka mu ubongo ndi m'matumbo , zikhoza kukhala ndi kanthu kena kogwirizana ndi kuyankhulana pakati pa matumbo ndi ubongo pokhudzana ndi kupsinjika maganizo , kapena kuyenera kutero chitani ndi zotsatira za mankhwala awa pa zigawo za ubongo zomwe zimayambitsa nkhawa ndi / kapena kupweteka.
Mulimonsemo, kupatsirana maganizo kumathandizira kuchepetsa ululu ndi kuchepetsa kupweteka kwa matumbo, makamaka ngati mankhwala osokoneza bongo amasankhidwa. Kufotokozera anti-depressant kwa IBS kumaonedwa kuti "yopanda pake," koma akulimbikitsidwa ndi American College of Gastroenterology.
Mitengo Yambiri Yobisika
Kafukufuku wogwira mtima wasonyeza kuti pafupifupi gawo limodzi mwa magawo atatu a IBS-D mwina akhoza kukhala ndi vuto lotchedwa bile acid m'mimba (BAD). Chizindikiro cha izi chikhoza kukhala chakuti kutsekula m'mimba kumachitika mwamsanga mutangodya. Matendawa angapindule ndi mankhwala osokoneza mankhwala omwe amatchedwa bile acid binders. Mankhwalawa ndi awa:
- Cholestyramine (Questran)
- Colesevelam (WelChol)
- Colestipol (Oyang'anira Colestid)
> Zotsatira:
> Bungwe la American College of Gastroenterology IBS Task Force "Umboni Wowonetsera Umboni pa Ulamuliro wa Irritable Bowel Syndrome" American Journal of Gastroenterology 2009: S1-S35.
> Lazaraki, G., Chatzimavroudis, G. & Katsinelos, P. "Posachedwapa apititsa patsogolo chithandizo chamankhwala cha matenda opweteka a m'mimba" World Journal of Gastroenterology 2014; 20: 8867-8885.
> J J, Vanuytsel T, Corsetti M. "Masiku Ano Kukonzekera kwa Matenda Osautsa Amadzimadzi: Osangokhala Amtundu Wambiri." Matenda Odulidwa Amagazi 2016; 34: 566-573.