Kuchepetsa Zizindikiro za Irritable Bowel Syndrome
Viberzi (eluxadoline) ndi mankhwala ovomerezedwa ndi US Food and Drug Administration (FDA) pofuna kuchiza kutsekula m'mimba-makamaka IBS (IBS-D) mwa akuluakulu. Viberzi inalinganizidwa kuti igwire ntchito m'deralo pamtunda wothandizira kuti athetse kutsekula m'mimba komanso kuchepetsa ululu wamimba chifukwa cha matendawa.
Ngakhale madokotala sakudziwa bwinobwino zomwe zimayambitsa zizindikiro za IBS (kuphatikizapo kupweteka kwa m'mimba, kuphulika, gasi, kutsegula m'mimba, kapena kudzimbidwa), Viberzi ikhoza kupereka chithandizo kwa odwala omwe sagwira ntchito kwa anti-diarralal agents.
Momwe Viberzi Amagwirira Ntchito
Viberzi imapezeka ndi mankhwala ndipo imakonzedwa kuti imatengedwa pakamwa, kawiri tsiku ndi tsiku, ndi chakudya. Zimabwera piritsi yophimba filimu ya 75-milligram ndi 100-milligram.
Viberzi imagwira ntchito popangitsa kapena kulanda mapulogalamu osiyanasiyana a opioid m'magazi. Awa ndi omwe amalandira mavitamini motility , kumva kupweteka, komanso kutsekemera kwa m'mimba. Viberzi ndi yodabwitsa chifukwa imalimbikitsa mitundu iwiri ya kulandira ndi kulepheretsa wina, kupereka mpumulo popanda kuvomereza.
Zipangizozi zimagwira ntchito zosiyanasiyana.
- Mu receptors ndi omwe amachititsa matumbo motility (kupangika kwa m'mimba minofu).
- Kappa receptors amaletsa kupopera kwa coloni.
- Malonda a Delta amalumikizidwa m'mitsempha ya m'mimba.
Kuwonjezera kwa kumenyana ndi anthu omwe amatha kulandira mankhwalawa ndizofunika kwambiri kuti asagwiritsidwe ntchito ndi mankhwala ena monga Imodium (loperamide) ndi Lomotil (atropine / diphenoxylate) zomwe zimakhudza kwambiri mu ndi kappa receptors.
A FDA adavomereza Viberzi pogwiritsa ntchito mayesero awiri a Gawo III omwe amatsimikizira kuti mankhwalawa amapereka bwino kwambiri pafupipafupi komanso mofulumizitsa mavitamini ndi kupweteka kwa m'mimba komanso kusagwirizana.
Zotsatira za Mankhwala
Zotsatira za Viberzi ndizochitika m'mimba mwachirengedwe koma zimakhudzanso machitidwe ena chifukwa cha zotsatira za opioid.
Nthaŵi zina, zizindikiro za mankhwalawa zingayambitse zomwezo zomwe zimachitikira ndi IBS. Zina mwa zotsatira zofala kwambiri:
- Nausea
- Kupweteka m'mimba
- Matenda othamanga kwambiri
- Kuthamanga
- Kuthamanga kapena mphuno yonyansa
- Kutseka
- Bronchitis
- Chizungulire
- Gasi
- Rash
- Kutopa
Mphuno ya opioid ikhoza kukhudza sphincter ya Oddi (valve pamene ikuyendetsa kutuluka kwa bile ndi pancreatic flu m'matumbo). Ngati izi zichitika, kupanikizika kumatha.
Zomwe zili choncho, Viberzi sangathe kuuzidwa kwa anthu omwe alibe ndulu (chiwalo chimene chimatulutsa bile) kapena amene ali ndi matenda a pancreatitis, kuwonongeka kwa chiwindi, kutsekedwa kwa bongo, kapena kudzimbidwa kwakukulu. Kuchekera kuchipatala ndi imfa zafotokozedwa mwa anthu omwe alibe ndulu yomwe inatenga miyeso yochepa ya Viberzi.
Tiyeneranso kupewa anthu omwe amamwa zakumwa zoledzera katatu patsiku.
Mankhwala opioid, Viberzi ali ndi mwayi wozunza ndi / kapena kudalira. Iyenera kugwiritsidwa ntchito pokhapokha kuyang'aniridwa ndi dokotala. Ngakhale kuti zotsatira zake sizing'ono kwambiri kuposa Oxycontin (oxycodone), zingayambitse kupwetekedwa ngati zikuchitiridwa nkhanza komanso zimadalira opioid kudalira.
> Zotsatira:
> Davenport, J ;; Covington, P .; Bonifacio, L. et.al. "Zotsatira za ogulitsa oatata OAT3 ndi OATP1B1 ndi efflux wonyamula MRP2 pa pharmacokinetics ya eluxadoline." J Clin Pharmacol. 2015; 55: 534-42. DOI: 10.1002 / jcph.442.
> Nkhunda, L .; Lembo, A .; Randall, C. et.al. "Odwala Eluxadoline Opindula ndi Irritable Bowel Syndrome Ndi Kutsekula m'mimba Phunziro 2." Gastroenterology 2013; 145: 329-38. DOI: 10.1053 / j.gastro.2013.04.006.
> Utsogoleri wa US Food and Drug Administration. "FDA imachenjeza za chiopsezo chowonjezereka cha kugwidwa kwakukulu koopsa ndi mankhwala osokoneza bongo Viberzi (eluxadoline) odwala popanda ndulu." Silver Spring, Maryland; inatuluka mu August 2016.