Imbruvica (ibrutinib) ndi mankhwala osokoneza bongo omwe amaimira kusintha kwa nyanja momwe timachitira matenda aakulu a khansa ya m'magazi (CLL) ndi ma B-cell malignancies. Makamaka, Imbruvica amasintha mankhwala a khansa ya m'magazi kuchoka ku mankhwala a chemotherapy osokoneza bongo kuti awonongeke ngati mapuloteni otchedwa enzymatic finesse.
Kodi CLL N'chiyani?
Lymphocytic khansa ya m'magazi ndi yowopsa kwambiri ya khansa ya m'magazi m'mayiko a Azungu.
(Matendawa amawakhudza azungu ndi kufooka kwambiri ku America, anthu a ku Puerto Rico, ndi Asiya.) Matendawa amapezeka kwambiri kwa anthu achikulire omwe ali ndi zaka zapakati pa zaka 72.
Matenda a khansa ya m'magazi ndi khansa ya ma Bymphocytes B yomwe nthawi zambiri imapereka chitetezo cha mthupi ndipo imakhala gawo lalikulu la chitetezo chathu cha mthupi.
Ndi CLL, kupweteka kwa ma lymphocytes a B leukemia kumaphatikizapo ndipo kumatulutsa maselo ambiri a m'magazi, magazi ndi maselo. Ndi nthenda ya maselo a thupi omwe thupi lathu limafunikira ngati maselo ofiira a magazi ndi maselo oyera a magazi, CLL ikhoza kufooketsa kwathu kuthetsa matenda ndi kuyambitsa matenda a m'thupi.
Kutsatsa kwa anthu omwe ali ndi CLL amayendetsa masewerawo. Anthu ena ali ndi mwayi ndipo amakhala ndi zaka zambiri ndi matenda osokoneza bongo omwe sasowa mankhwala. Komabe, ena amavutika kwambiri ndi mankhwala a chemotherapy.
Zizindikiro zapadera kwa omwe akudwala CLL patsogolo ndizo:
- kutopa
- kulemera
- malungo
- thukuta usiku
- Zilonda zamakono
- nthenda yotentha kapena chiwindi chomwe chimapangitsa kuti munthu asamamve msanga (kumverera koyamba kwa chidzalo)
- matenda opatsirana
Mu 2015, National Cancer Institute inanena kuti pa 14620 milandu ya CLL yapezeka, panali anthu 4650 akufa.
Kodi ndizofunika bwanji za Imbruvica?
Mpaka posachedwa, chithandizo cha CLL chinangokhala chemotherapy pamodzi ndi immunotherapy kapena chemoimmunotherapy.
Ngakhale chemotherapy yokha imangokhala yokwanira kwa ena a CLL, kuwonjezereka kwaposachedwapa kwa rituximab, ndi mankhwala osamalitsa thupi, kungathandizire kupitirizabe kupulumuka mwa kuyesa kuchotsa. Makamaka, rituximab imalowera antigen ya CD20 pa ma lymphocyte B. Mwamwayi, anthu ena (omwe ali ndi kusintha kwa del 177 / TP53 kapena kuchotsedwa mu chromosome 17) amayankha mosavuta chemoimmunotherapy.
Chemotherapy ya CLL imaphatikizapo parenteral administration (jekeseni) ya othandizira osiyanasiyana pofuna kupha osati kungowonongeka mofulumira maselo komanso kumagawanitsa maselo, komanso. Njirayi ikufotokozera chifukwa chake anthu omwe ali pa chemo amakhudzidwa ndi mavuto osiyanasiyana kuphatikizapo tsitsi, kutaya kwa m'mimba, komanso, ngati ali ndi CLL, amachititsa kuti anthu azivutika kwambiri komanso azivutika.
Ngakhale kuti chemo imavomereza kulondola kwa kayendedwe kake, Imbruvica ili ngati chotupa cha opaleshoni ndipo chimakhala chimodzimodzi. Mwachindunji, Imbruvica imatulutsa tizilombo toyambitsa matenda omwe amatchedwa tyutine (tyrosine kinase) a Butk (Btk) omwe amawasiyanitsa ndi maselo oopsa kapena a B. Popanda kumangirira Btk, Imbruvica imaponyera mchera wa monkey mu njira yopanda mphamvu ya maselo a B, yomwe imalepheretsa kukula kwa maselo, kufalikira, ndi kupulumuka kwa maselo oopsa a B.
N'zochititsa chidwi kuti ofufuza amanena kuti Imbruvica ingagwiritsidwe ntchito ndi njira ina yowonjezera imene imachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Mwachindunji, komanso mwatsatanetsatane m'magazini yotchedwa Nature Biotechnology , Imbruvica ikhoza "kulepheretsa mankhwala a chemokine receptor ndi kuzindikiritsa integrin ndi kuletsa BTK, ndiyeno kusamukira kwa maselo ndi kumamatira ku maselo osokoneza bongo." Imbruvica administration, maselo a CLL akuchulukitsa magazi ndipo akhoza amafera pomwepo, osatetezedwa ndi tizilombo toyambitsa matenda omwe amaperekedwa ndi minofu. "
Kuwonjezera pa CLL, Imbruvica imathandizanso ndi mitundu yambiri ya B-cell malignancies.
Chifukwa chake, kuwonjezera pa CLL, a FDA adatulutsa mankhwalawa mofulumira kapena ochiritsira mankhwala a Waldenström's macroglobulinemia ndi mantle cell lymphoma. Palibe mankhwala ena omwe adalandira mankhwala ambiri opatsirana!
Ngati inu kapena wokondedwa wanu muli ndi CLL kapena b-cell malignancy, chiyambi cha Imbruvica ndithudi ndi chinachake choti musangalale nacho. Ponena za kuwonongeka kwa mwazi, Imbruvica akuyembekezeratu kuti akhoza kupambana ndi rituximab. Komanso, Imbruvica sizothandiza kwambiri kuposa rituximab monga monotherapy komanso imagwiritsidwa ntchito pamlomo ndi yothandiza ndi matenda opatsirana komanso omwe amatha kubwereranso.
Zotsatira:
Mutu wotchedwa "Imbruvica-wotsatira mankhwala akuluakulu a khansa ya B-cell yomwe inavomerezedwa ndi FDA" ndi Malini Guha yofalitsidwa mu Nature Biotechnology mu 2014.
Mutu wotchedwa "Ibrutinib (Imbruvica): Buku Lachilendo Cholinga cha Chronic Lymphocytic Leukemia" ndi S Parmar ndi olemba mabuku omwe amafalitsidwa mu P & T mu 2014.