Prucalopride ndi mankhwala omwe amachititsa kuchipatala nthawi yaitali - vuto la thanzi lodziwika ndi gawo lovuta komanso lovuta la zidole kwa nthawi yaitali, pamodzi ndi zizindikiro zina zosautsa monga kumimba mimba, flatulence, ngakhale kusanza. Njira zamankhwala zowonongeka nthawi zambiri zimaphatikizapo zakudya ndi kusintha kwa moyo ndi / kapena laxatives.
Prucalopride pakalipano imapezeka ku Ulaya, pansi pa dzina lakutchedwa "Resolor" ndi ku Canada monga "Resotran". The European Medicines Agency (EMA) yavomereza kugwiritsa ntchito mankhwala osokoneza bongo (Resolor) pokhapokha pofuna kuchipatala kwa amayi omwe sanayankhe kugwiritsa ntchito mankhwala osokoneza bongo . Maphunziro akuchitidwa kuti apeze chivomerezo kudzera mu EMA kuti agwiritse ntchito prucalopride mwa amuna omwe akuvutika ndi kudzimbidwa kosatha.
Kodi Pulopalde Zimagwira Ntchito Bwanji?
Prucalopride imadziwika ngati 5-HT4 agonist. Izi zikutanthauza kuti zimayambitsa ma-5-HT4 receptors kwa serotonin ya neurotransmitter. Ntchitoyi imagwiriridwa kuti iwonjeze motility ya m'mimba mwa kuwonjezereka, kapena kupweteka kwa matumbo komwe kumatulutsa thupi, kutulutsa mpando mosavuta kudutsa ndipo kumapangitsa kuti thupi liziyenda mobwerezabwereza.
Prucalopride ali ndi kalasi imodzi ya mankhwala monga Zelnorm.
Komabe, prucalopride yalinganizidwa kuti ikhale yosiyana ndi thupi kuti athe kuchepetsa mwayi wosawoneka koma woopsa kwambiri wa mtima umene unachititsa Zelnorm kuchotsedwa pamsika.
Kodi Prucalopride Imathandiza Bwanji Pakuteteza Kachilombo ka Nthawi Zonse?
M'mayesero am'chipatala mpaka lero, prucalopride yasonyezedwa kuti ili pamwamba pa malobo m'malo awa:
- Kuwonjezereka kwafupipafupi kwa kayendedwe kake.
- Kukulitsa malingaliro oleza mtima za khalidwe la moyo.
- Zotsatirapo za wodwalayo kuzindikira kuti kudzimbidwa sikovuta.
Kodi Zotsatira Zake za Prucalopride N'zotani?
Pofufuza mpaka lero, zotsatirapo zotsatirazi zakhala zikuchitika:
- Kutsekula m'mimba
- Mutu
- Nausea
Kodi Prucalopide Athandiza IBS?
Mu kafukufuku wake wamakono, American College of Gastroenterology imatsimikizira kuti kafukufuku amathandizira mphamvu ya prucalopride kwa kudzimbidwa kosatha ndi IBS-C. Ofufuza a ACG amavomereza kuti prucolopride sichitengera ngozi ya Zelnorm ya zoopsa za mtima.
Ndani sayenera kutenga Prucalopide?
Anthu ena ali pachiopsezo chachikulu chokhala ndi zotsatira zoopsa kapena zovuta chifukwa chotenga prucalopride. Izi zikuphatikizapo anthu:
- Mankhwala osokoneza bongo amadziwika ndi mankhwala kapena mankhwala ake onse
- Kuwonongeka kwa chiwerewere chosowa dialysis
- Matenda a m'mimba amatsekedwa kapena kutsekedwa
- Chilema choletsedwa
- Zokwanira zotupa ziwalo za m'mimba
- Matenda owopsa osagwedera, makamaka a arrhythmias kapena ischemic heart disease.
Zotsatira:
Ford, A., etal.al. " American College of Gastroenterology Monograph pa Ulamuliro wa Irritable Bowel Syndrome ndi Chronic Idiopathic Constipation " American Journal of Gastroenterology 2014 109: S2-S26.
Ford, A. & Suares, N. "Zotsatira za mankhwala osokoneza bongo ndi mankhwala opatsirana mu mankhwala ochiritsira osadziwika bwino: kukonzanso ndondomeko ndi kuwonetsa mchitidwe" Gut 2011 2011 60: 209-218.
Maneerattanaporn, M., Chang, L., & Chey, W. "Njira Zochiritsira Zamakono za Madzi za Irritable Bowel Syndrome" Zipatala za Gastroenterology za North America 2011 40: 22-243.
"Movetis ayambitsa chiyeso chachitatu chachilendo ndi odwala amuna omwe ali ndi matenda aakulu" Movetis NV Press Release September 24, 2010.
"Kuthetsa" European Medicines Agency Anapindula pa March 17, 2011.
Quigley, E. "Prucalopride: chitetezo, mphamvu ndi ntchito zomwe zingatheke Zotsatira zachipatala mu Gastroenterology 2012 5: 23-30.