M'mbuyomu, mankhwala opatsirana pogwiritsira ntchito mankhwala ochiritsira matenda osakanizika kwambiri (IBS-C) anali ochepa. Mwamwayi, izi zikusintha ndipo mankhwala ambiri a mankhwala amapezeka chifukwa chochiza kudzimbidwa kosatha.
Amitiza (Lubiprostone)
Amitiza imavomerezedwa ndi a FDA kuti azisamalira IBS-C, komanso kudzimbidwa kwachilendo kosatha (CIC).
Amitiza amagwira ntchito poonjezera kuchuluka kwa madzi m'matumbo ndikuthandizira kuchepetsa zigawo.
Mankhwalawa amagwira ntchito pamagulu a maselo monga momwe amachitira (mapuloteni) omwe amaphatikizapo kutumiza chloride, motero Amitiza amadziwika ngati chloride channel activator. Anthu ambiri omwe amatenga Amitiza adzalandira mpumulo wa zizindikiro m'maola 24.
Musagwire Amitiza ngati muli ndi chitetezo chamatumbo, mutsekula m'mimba, kapena muli ndi pakati kapena mukuyamwitsa.
Lactulose
Lactulose ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochizira. Amagulitsidwa pansi pa mayina osiyanasiyana. Izi zikuphatikizapo Cephulac, Chronulac, Constilac, Cholac, Constulose, Duphalac, Enulose, Generlac, ndi Kristalose.
Lactulose ndi shuga yopangidwa ndi anthu yomwe imathyoledwa ndi mabakiteriya m'matumbo, njira yomwe imakoka madzi ambiri m'matumbo. Kuwonjezeka kwa madzi kumachepetsa, kuwonjezeka, ndi kuimika pachitetezo.
Mpweya wapamwamba wa chitseko umathandiza kulimbikitsa motility moziloni ndipo motero amalimbikitsa kayendedwe kake.
Lactulose kawirikawiri amalangizidwa kuti agwiritsidwe ntchito panthaŵi yochepa. Izi sizitengera chisankho choyamba cha dokotala ngati sichilekerera (kumayambitsa kupopera kwambiri ndi mafuta) ndipo sichigwira ntchito kwambiri kuposa njira zina.
Musanayambe kumwa lactulose, onetsetsani kuti adokotala amadziwa ngati mukukonzekera opaleshoni, akudwala matenda a shuga, kapena ali ndi mimba kapena akuyamwitsa.
Linzess (linaclotide)
Linzess yavomerezedwa ndi FDA kuti athetse IBS-C ndi CIC. Ku Ulaya, mankhwala amachitcha kuti Constella ndipo amavomerezedwa kuti azisamalira IBS-C.
Mankhwalawa amatchedwa guanylate cyclase-C agonist. Zimagwiritsidwa ntchito powonjezera kuchuluka kwa madzi m'kati mwa matumbo chifukwa cha kuchulukanso kwa mawere ndi kuchepa kwa m'mimba.
Pulpopride
Prucalopride imatchulidwa ngati 5-HT agonist pamene ikugwiritsira ntchito receptors kwa neurotransmitter serotonin (5-HT). Mwatsoka, prucalopride sichinavomerezedwe kuti igwiritsidwe ntchito ndi FDA ndipo sichipezeka ku US Iko ikupezeka ku Ulaya ndi ku Kanada, ndipo pali zolephera pa mankhwala ake.
Miralax
Mosiyana ndi mankhwala ena omwe afotokozedwa patsamba lino, Miralax safuna mankhwala . Komabe, madokotala nthawi zambiri amalimbikitsa Miralax chifukwa chowathandiza kuti asamangidwe. Miralax amakoka madzi m'chitetezo, amachepetsanso ndipo amachititsa chidwi choyendayenda.
Zelnorm (tegaserod)
Zelnorm ndi mankhwala omwe adapangidwa kuti athetse IBS-C ndi CIC.
Iyenso imagwira ntchito powonjezera kuchuluka kwa serotonin ya neurotransmitter m'maselo a m'matope.
Chifukwa chodziŵa mavuto aakulu azaumoyo, mankhwalawa amapezeka pokhapokha mwadzidzidzi. Malemba ake ayenera kulamulidwa mwachindunji ndi FDA.
Chidziwitso Chokhudza Antidepressants
Kugonjemera sikuvomerezedwa ngati chithandizo cha kudzimbidwa. Komabe, chifukwa cha kupweteka kwakukulu kwa odwala omwe ali ndi IBS komanso kuti matenda opatsirana amatha kukhala ovuta kupweteka, dokotala angapereke mankhwala olepheretsa munthu kugonana ndi IBS-C .
Odwala matenda opatsirana omwe amasankhidwa kwa munthu amene amatha kuvomereza angakhale kuchokera ku kalasi yotchedwa serotonin reuptake inhibitors (SSRIs).
Izi sizingapangitse kuti zidziwitse. Zitsanzo za SSRI zikuphatikizapo Celexa, Lexapro, Prozac, Paxil, ndi Zoloft.
> Chitsime:
> Ford A, et.al. American College of Gastroenterology Monograph pa Ulamuliro wa Irritable Bowel Syndrome ndi Chronic Idiopathic Constipation . American Journal of Gastroenterology. 2014; 109: S2-S26. do: 10.1038 / ajg.2014.187
> US Food & Drug Administration. Zelnorm (tegaserod maleate) Information. 2016. https://www.fda.gov/Drugs/DrugSafety/ucm103223.htm.