Gawo 2 la 3
Monga tinaphunzirira mbali imodzi, Post-Exertional Malaise ndi chiyani, anthu omwe ali ndi matenda osatopa ( ME / CFS ) amawonekeratu nthawi zambiri pochita khama. Ichi ndi chizindikiro chodziwikiratu cha matendawa ndipo omwe ofufuza akhala akuyesera kuti adziwe zaka. Tili ndi zambiri zoti tiphunzire za chizindikiro ichi, koma tikudziwa kuti zovuta zambiri zakuthupi zimagwirizana ndi post-exertional malaise (PEM).
Zovuta Zachilengedwe
Ochita kafukufuku apeza zovuta zokhudzana ndi maseŵera olimbitsa thupi m'zinthu zosiyanasiyana, kuphatikizapo chitetezo cha m'thupi, dongosolo la mitsempha lalikulu, ndi mtima wamtima. Pakalipano, sanathe kuganiza kuti izi sizinayambitse chifukwa cha PEM. Kupenda kwa chaka cha 2014 cha buku lachipatala lomwe linatanthawuza machitidwe ambiri a chitetezo cha mthupi ku ME / CFS, ambiri omwe amangiriridwa kuchita masewera olimbitsa thupi ndi PEM. Izi zikuphatikizapo:
- Yankho lovomerezeka kwambiri mu njira yothandizira (gawo la chitetezo cha mthupi chomwe chimathandiza ma tizilombo toononga thupi lanu),
- Kuwonjezeka kwa kupsyinjika kwa okosijeni (mtundu wa mawonongedwe a ma cell) kuphatikizapo osauka antioxidant yankho,
- Kusintha kwa maselo a chitetezo cha mthupi.
Kafukufuku wina (Morris 2014) adafufuza zolakwika zokhudzana ndi chinthu chotchedwa adenosine triphosphate (ATP), yomwe ndi mawonekedwe a mphamvu zamagetsi. ME / CFS imakhulupirira kuti imagwirizanitsidwa ndi luso lotha kupanga ATP pa mlingo wa mitochondrial.
(Mitochondria ndizomwe zili m'maselo anu zomwe zimasintha zakudya m'thupi mwa ATP.)
Kuphunzira kwa 2015 pogwiritsa ntchito kachipangizo kameneka kameneka (Lengert) kankayang'ana pazitsulo zochepa za ATP, zomwe zikhoza kuchititsa kuchuluka kwa maselo a maselo. Njira yothetsera kuyambira ndi otsika ATP yatsogolera ku matenda osokoneza bongo komanso kupsyinjika kwa okosijeni, malinga ndi chitsanzo.
Ochita kafukufuku amanena kuti kuchita khama mobwerezabwereza kunapangitsa kuti vutoli likhale loipa kwambiri. Mu 2012, pepala lofufuza ntchito ya mitochondrial ndi ME / CFS (Morris) inakambirana zovuta zambiri, monga:
- Anayambitsa immuno-yotupa njira,
- Kuwonjezeka kwa mavitamini otchedwa proto inflammatory cytokines ,
- Kuwonjezeka kwa nyukiliya-kB,
- Kuwongolera mu ntchito za mitochondrial, kuphatikizapo kutsika kwa ATP.
Ofufuzawo anafotokoza kuti izi, makamaka mbali zina, zimatha kufooka kwa mitochondrial, kutanthauza kuti pamene thupi limafuna mphamvu (monga ATP), mphamvu sizingatheke.
Phunziro lina la 2015 linagwiritsira ntchito kanema kamene kamatchedwa kachipangizo kameneka kamene kamapangitsa kuti okosijeni azigwiritsa ntchito pochita masewera olimbitsa thupi. Poyerekeza ndi anthu omwe ali ndi thanzi labwino, gulu la ME / CFS linapezeka kuti likusintha mosiyanasiyana mu mpweya wa hemoglobini (mapuloteni omwe ali ndi maselo ofiira omwe amachititsa mpweya ku maselo anu) pambuyo poyesera.
Kusakaniza kulikonse kwazifukwazi kungapangitse PEM. Komabe, ofufuza ali ndi ntchito yambiri patsogolo pawo. Akatswiri ena amanena kuti zovuta zina zingagwiritsidwe ntchito ngati chizindikiro chodziŵika bwino cha ME / CFS pomwe ena amakhulupirira kuti PEM ikhoza kukhala njira yothandiza madokotala kuti azindikire kuopsa kwa matenda.
Chofunika kwambiri, pamene tiphunzira zambiri za zomwe zikuchitika m'thupi panthawi ya PEM, timayandikira kwambiri kuti tiwone momwe tingachitire.
Dziwani zambiri
Zotsatira:
Lengert N, Drossel B. Zipangizo zamakono. 2015 Jul; 202: 21-31. Mu silico kusanthula kusagwirizana kwa zochitika mu myalgic encephalomyelitis / matenda otopa matenda.
Miller RR, et al. Journal of medicine translation. 2015 May 20; 13: 159. Kuchita masewera olimbitsa thupi pogwiritsa ntchito makina osakanikirana kwambiri a myalgic encephalomyelitis / odwala matenda otopa odwala poyerekeza ndi kuyendetsa bwino: phunziro lolamuliridwa ndi anthu.
Morris G, Maes M. Medical Opotoza. 2012 Nov; 79 (5): 607-13. Kuwonjezeka kwa nyukiliya-kB ndi kuwonongeka kwa p53 ndi njira zofunikira mu myalgic encephalomyelitis / matenda osatopa matenda (ME / CFS).
Morris G, Maes M. Matenda a ubongo. 2014 Mar; 29 (1): 19-36. Matenda a mitochondrial mu myalgic encephalomyelitis / matenda aakulu otopa amatha kufotokozedwa ndi njira zowonongeka za thupi, zotentha ndi zowonongeka.
Nijs J, Nees A, et al. Chitani zomwe mukuchita. 2014; 20: 94-116. Magwero a chitetezo cha chitetezo cha chitetezo cha chitetezo cha mthupi mwa odwala omwe ali ndi matenda otopa / myalgic encephalomyelitis: ndondomeko yolemba mabuku.