Mmene Khungu Lanu ndi Ntchito Yanu Yopangidwira Imagwirira Ntchito Pamodzi Kuti Mukhale Wathanzi
Maselo a Langerhans (LCs) ali pakhungu ( epidermis ndi dermis ) ya kupuma, digestive ndi urogenital mathirakiti. Zikhoza kupezeka m'matenda ena monga ma lymph nodes makamaka makamaka pamene Langerhans selo histiocytosis (LCH) imakhudzidwa.
LCs zimakutetezani mwa kusunga maantijeni owopsa (chinthu chilichonse chimene chimachititsa kuti chitetezo cha mthupi chitulutsa ma antibodies) kuti asalowe m'thupi lanu.
Maselo a Langerhans Amagwira Ntchito Bwanji
M'chaka cha 1868, wophunzira wina wazaka 21 wa ku Germany, Paul Langerhans, anapeza kuti maselo a Langerhans ali m'mbali zonse za epidermis ndipo ali m'gulu la a dendritic. Maselo operewera ndi maselo osatetezeka omwe amapereka ma antigen kwa chitetezo cha mthupi ndipo amapezeka mthupi lonse. LCs ndi maselo a dendritic pakhungu ndipo popeza maselo a dendritic amathandiza kwambiri poonetsetsa kuti chitetezo cha mthupi chikhalepo pamaso pa tizilombo toyambitsa matenda ndi zipangizo zina zakunja, khungu ndilofunika kwambiri ku matenda.
LCs poyamba ankaganiziridwa kukhala mbali ya mitsempha ya mitsempha ndipo amangoyang'anitsitsa chitetezo cha mthupi ku antigen. M'malo mwake, kufufuza kwapeza kuti LC's imafooketsa momwe khungu limayendera ku matenda ndi kutupa mwa njira ziwiri zosiyana:
- Mwa kuteteza khungu lanu ku matenda.
- Mwa kulimbikitsa zochita zowopsa.
Maselo a Langerhans amapereka maselo apadera-maselo oteteza ku chitetezo monga maselo T ndi maselo B-atangozindikira mtundu uliwonse wa ngozi pakhungu.
Ma chitetezo a m'thupi amatenga ochimwa monga mabakiteriya ndi mavairasi ndipo amalimbana ndi kuvulala monga kudulidwa ndi kupweteka.
Chilengedwe cha khungu chimayang'aniridwa ndi LCs kuti zinthu zisawonongeke ndipo maselo a chitetezo cha mthupi amatumizidwa kuti abwezeretse chidziwitso cha othawa amitundu ina. Thupi limagwiritsa ntchito maselo akuluakulu opweteka kuti amenyane ndi othawa pogwiritsa ntchito mankhwala osokoneza bongo kapena kupanga minofu yambiri kuti ateteze ku matenda.
LCs ndi Skin Conditions
Kafukufuku watsopano akusonyeza kuti maselo a Langerhans amatha kuzindikira ndi kumenyana ndi mavairasi ochokera kumadera oyandikana nawo, potero amateteza matenda. Kupeza kuti ma LC amathandizidwa ku chitetezo cha mthupi mosiyana ndi matenda osiyanasiyana, angachititse kuti zikhale zovuta zogonana .
Kupeza izi kumathandizanso kusintha kwambiri kumvetsetsa kwa njira zomwe zimayambitsa matenda ambiri a khungu monga:
- Psoriasis : Matenda omwe maselo a khungu amamanga ndi kupanga masikelo amatsagana ndi ubweya wofiira, kunyowa ndi mazira ouma.
- Lupus : Matenda opweteka amachititsa kuti chitetezo cha mthupi chiteteze ziwalo zake.
- Khansara ya khungu : Khansa yofala kwambiri ku US, yomwe imadziwika ndi kukula kwa maselo a khungu.
Pakhoza kukhalanso chitukuko cha katemera wa m'magazi omwe amaperekedwa kudzera mu khungu (Epicutaneous vaccination) lomwe limagwiritsa ntchito kukweza LCs pakhungu ndi antigen. Kafukufuku wayamba kale kuyang'ana katemera operekedwa kudzera mu khungu loletsedwa khungu kuti athetse kukula kwa khansa ya khansa , khansara yamtundu wovuta.
Kodi Lagerhans Cell Histiocytosis (LCH) ndi chiyani?
Selo la Langerhans histiocytosis (LCH) ndilo lachilendo, matenda omwe amachititsa kuti khungu, mafupa ndi ziwalo zina ziwonongeke.
Maselo olemera kwambiri ofanana ndi LCs amapangidwa mu matendawa, komabe, LCH maselo amasonyeza osiyana, maselo a magazi omwe amachokera ku matendawa.
Zotsatira:
Langerhans P. Über die Nerven der Menschlichen Haut. Maselo Arch [A] 1868; 44: 325-337.
Seo N., et al. Katemera wa peptide wochuluka mwa njira ya corneum yomwe imasokoneza khungu la murine pofuna kuyesa kugwiritsira ntchito tumor immunoprophylaxis. Proc Natl Acad Sci USA 2000; 97: 371-376.
Yagi H., et al . Kuchepetsa mankhwala opatsirana pogwiritsa ntchito mankhwala a cytotoxic mwa anthu ndi katemera wambiri wa peptide. Cancer Res 2006; 66: 10136-10144.