Katemera ndi Matenda a Hypocretin Angathe Kusiyanitsa Mitunduyi
Kudwala matenda osokoneza bongo nthawi zonse kumadziwika ndi kugona kwapakati pa tsiku, koma pali zizindikiro zina ndi zotsatira zowonetsera zomwe zimagwiritsidwa ntchito kusiyanitsa mitunduyi. Pali mitundu iwiri ya matenda osokoneza bongo, koma kodi kusiyana kotani pakati pa mtundu woyamba wa matendawa ndi mtundu wa 2? Phunzirani za kusiyana kumeneku, kuphatikizapo ntchito yothandizidwa ndi kuyesa kwa masitepe a hypocretin mu cerebrospinal fluid (CSF).
Zizindikiro Zoperekera Nsapato Zing'onozing'ono Zikhoza Kusiyanitsa Mitundu Yina
Mitundu yonse iwiri ya matenda osokoneza bongo imaphatikizapo kufunika kosalekeza kugona kapena usana kugona. Popanda kugona, kumangokhalira kugonana sikunali koyenera kudziwa. Palinso zizindikiro zina zogwirizana, ndipo zina mwa izi zingathandize kusiyanitsa mitunduyi.
Pali mitundu iwiri ya mankhwala osokoneza bongo: mtundu wa 1 ndi mtundu 2. Fomu 1 ingakhalepo kukhalapo kwa chizindikiro cha cataplexy. Kataplexy amatanthauzira ngati zochitika zosawerengeka, mwachizolowezi zowonongeka mwadzidzidzi wa mawu osokonezeka ndi kusunga chidziwitso. Kufooka uku kungakwiyitse ndi kukhudzika kwakukulu. Maganizo amenewa nthawi zambiri amakhala abwino; Mwachitsanzo, kugwiritsidwa ntchito kumagwiritsidwe ntchito ndi kuseka. Kufooka kungaphatikizepo nkhope, mikono, kapena miyendo. Ena achipatala adzakhala ndi maso a maso, kutsegula pakamwa, kutulutsa lilime, kapena kupweteka mutu. Anthu ena amatha kugwa pansi pamene akugwedezeka.
Mitundu yonse iwiri ya matenda osokoneza bongo ingaphatikizepo kugona tulo ndi ma hypnagogic hallucinations . Nthawi zambiri kugona tulo usiku kumachitika mkhalidwe wonsewo.
Udindo wa Kuyesedwa kwa Hypocretin ndi MSLT
Kuyezetsa kwachindunji kungagwiritsidwe ntchito posiyanitsa pakati pa mitundu iŵiri ya mawonekedwe achiwerewere. Kugonana kwapadera kwa tsiku ndi tsiku kumatsimikiziridwa ndi zotsatira za mayesero angapo ogona tulo (MSLT).
Mayesowa amatsatira phunziro lagona tulo ndipo akuphatikizapo mipata inayi kapena isanu yomwe imapezeka pakapita maola awiri. Nkhaniyi imapatsidwa mpata woti agone, ndipo anthu omwe ali ndi vutoli amatha kugona m'miyezi yosachepera 8. Kuphatikizanso, kugona kwa REM kudzachitika mkati mwa mphindi khumi ndi zisanu (15) tulo timayamba maulendo awiri osakhala pansi.
Komanso, kuyezetsa magulu a hypocretin mu CSF zamadzimadzi monga gawo la kuponyedwa kwa lumbar kungakhale kuwulula. Ngati miyesoyi ikuyesedwa kuti ikhale yosakwana 110 pg / mL, izi zikugwirizana ndi matenda a mtundu wa 1. Ngati miyeso ndi yachilendo (kapena ayi) ndi katemera sichipezeka, sungani mtundu 2 wa mankhwala osokoneza bongo amapezeka ngati MSLT ndi yabwino. Ngati msinkhu wa hypocretin umayesedwa kuti ukhale wosazolowereka mtsogolo, kapena ngati kachilombo kamatuluka, matendawa angasinthidwe kuti apange 1.
Ngakhale kuti vutoli limakhala losavomerezeka, limapezeka kawirikawiri, ndi mtundu 1 wogwira pafupifupi 1 pa anthu 5,000. Matendawa ayenera kupangidwa ndi katswiri wa kugona yemwe amatha kuyesa kuyezetsa bwino ndikupereka chithandizo chabwino.
Ngati mukudandaula kuti mungakhale ndi zizindikiro za matenda osokoneza bongo, funsani kafukufuku ndi katswiri wogona omwe angakupatseni chisamaliro ndi chithandizo chimene mukufuna.
> Chitsime:
> American Academy of Sleep Medicine. Mndandanda wa zovuta za kugona, 3rd ed. Darien, IL: American Academy of Sleep Medicine, 2014.