Msuzi wofiira wofiira (RYR) ndi chakudya chowonjezera cha zakudya chomwe chagulitsidwa ngati mankhwala osagwiritsidwa ntchito kuti athetse mafuta a kolesterolini .
RYR wakhala akugwiritsidwa ntchito ku China kwa zaka mazana ambiri pakuphika ndi kuchiza matenda a m'mimba ndi m'mimba. Komabe, popeza lagwiritsidwa ntchito ku US kwa nthawi yayifupi, yakhala ikutsutsana kwambiri.
Kodi Nsomba Yofiira Ndi Chiyani?
RYR ndi mpunga wopangidwa ndi fermenting mpunga ndi nkhungu Monascus purpureus .
Lili ndi zinthu zingapo zomwe zingachepetse mitsempha ya cholesterol, kuphatikizapo beta-sterols , monounsaturated fatty acids , ndi statin . Dzinalo la statin yomwe imapezeka mu RYR ndi monocolin K, koma imadziwika bwino ku US monga lovastatin (yotengedwa ngati Mevacor).
Kodi RYR Low Cholesterol?
Kafukufuku wasonyeza kuti RYR, monga momwe inkakhazikitsidwa ku China komanso yomwe idagulitsidwa ngati chakudya chambiri ku US, imachepetsanso kuchepa kwa mafuta a m'thupi .
Mwachitsanzo, pofufuza odwala 83 omwe ali ndi cholesterol chokwanira, zomwe zimachitika kwa RYR zakhala zikuchepetsa kuchepetsa cholesterol (204 vs. 338 mg / dL) ndi ma dilasi ya LDL (128 vs. 277 mg / dL) pakatha masabata asanu ndi atatu, poyerekeza ndi omwe amatenga placebo.
Kutsutsana
Chotsutsana, ndithudi, ndikuti RYR ili ndi statin yachibadwa. Statins, malinga ndi lamulo, ndi mankhwala ndipo motero amatsatira malamulo.
Mtsutso unayamba mu 1999, patangopita nthawi yochepa mayeso a chipatala poyamba adasonyeza kuti RYR ikhoza kuchepa kwambiri m'magazi a cholesterol. Panthawi imeneyo a FDA adagamula kuti RYR yokhala ndi monocolin K inali mankhwala, ndipo motero adalamula kuti ichotsedwe pamasalefu. Milandu inabweranso, ndipo (pambuyo pa zifukwa zingapo zambuyo ndi zotsutsa) Khoti la Mavoti la US la 10 linagwirizana ndi FDA.
Choncho, ku US, RYR ikhoza kugulitsidwa movomerezeka, koma ngati pangotengedwa njira zake zopangira kuchotsa monocolin K.
RYR akadakali kupezeka monga zakudya zowonjezera, ndipo amapangidwa ndi opanga angapo. Monga zakudya zowonjezera, malemba ake ndi zokhutirabe sizikulamuliridwa. Zimakhala zovuta kwambiri ngati sizingatheke kudziwa kuti chinthu china cha RYR chomwe chili pa alumali chili ndi chiyani.
Kafukufuku
Poyang'anizana ndi chisokonezo chonsechi, mayesero awiri a chipatala adawonekera kuti ngakhale m'nthawi ya FDA, zina za RYR zomwe zilipo ku US zimathandiza kuchepetsa ma cholesterol.
Mu 2009, kafukufuku wochokera ku Pennsylvania anasonyeza kuti pa odwala 60 omwe anayenera kusiya kumwa mankhwala osokoneza bongo chifukwa cha kupwetekedwa kwa minofu , kutenga RYR ndikuyambitsa kusintha kwa moyo kwa milungu makumi awiri ndi iwiri, kuchepetsa kuchepetsa thupi lonse ndi ma LLL cholesterol, poyerekezera ndi kutenga placebo ndi kupanga moyo womwewo umasintha.
Ndipo mu 2010, ofufuza a ku yunivesite ya Pennsylvania adanena kuti odwala amene anayenera kusiya kumwa mankhwala chifukwa cha kupwetekedwa kwa minofu, RYR inali yogwira ntchito ngati 20 mg patsiku la pravastatin (Pravachol) la mankhwala ochepetsa mankhwalawa. (Zonse za RYR ndi Pravachol zinangobweretsa zochepa chabe za kupweteka kwa minofu kawirikawiri.)
Mufukufuku wa 2009, apolisi anachita kafukufuku wa mankhwala pa RYR zomwe anagwiritsa ntchito pophunzira (kuchokera ku Sylvan Bioproducts ku Kittanning, Pennsylvania). Iwo anapeza kuti RYR akadali ndi monacolin K komanso ma monacolin ena asanu ndi atatu.
Zotsatira za kusanthula kwa mankhwala uku zikusonyeza zinthu ziwiri. Choyamba, zina za RYR zikupezeka ku US zikuoneka kuti zili ndi lovastatin, ndipo chachiwiri, ngakhale kuti lovastatin yonse yachotsedweratu, mankhwala ena ofanana ndi RYR (omwe FDA sali - koma makamaka oletsedwa) angakhale othandiza pochepetsa cholesterol .
Kodi Muyenera Kutenga RYR?
Pamwamba pamtunda, kutenga RYR kungawonekere kukhala woganizira mozama ngati mukufuna njira zosagwiritsire ntchito mankhwala a cholesterol kutsitsa. Komabe, zomwe mungakhale mukuchita ndikutenga zinthu zosawerengeka ndi zosadziwika za zinthu zina monga statin. N'zosatheka kunena, kuchokera kwa opanga kupanga opanga, kapena kuchokera ku botolo kupita ku botolo, zomwe mukugula.
Ngati mukufuna kuchepetsa cholesterol yanu popanda kutaya shati yanu ku makampani akuluakulu osokoneza bongo, funsani dokotala za mankhwala osokoneza bongo. Zimapezeka mosavuta, zotsika mtengo (mwinanso zotsika mtengo kuposa RYR), ndipo monga bonasi, mlingo umene mukupezawo umadziwika bwino, ndipo ukhoza kulamulidwa ndikusinthidwa kuti mukwaniritse zotsatira zanu.
Zotsatira:
Halbert SC, French B, Gordon RY, et al. Kulephera kwa yisiti ya mpunga wofiira (2400 mg kawiri tsiku lililonse) poyerekeza ndi pravastatin (20 mg kawiri tsiku lililonse) kwa odwala omwe sanagwirizane nawo. Am J Cardiol 2010; 105: 198-204.
Becker DJ, Gordon RY, Halbert SC, et al. Msuzi wa yisiti wofiira wa matenda odwala matenda odwala matenda odwala matenda odwala matendawa. Ann Internal Med 2009; 150: 830-839.
Gordon RY, Cooperman T, Obermeyer W, Becker DJ. Kusintha kwa kusiyana kwa maulendo a monacolin mu yisiti yofiira yamitolo mpunga: wogula samalani! Arch Intern Med 2010; 170: 1722.