Dokotala Wodalirika wa Mankhwala a MS, Koma Pali Mafunso Ambiri
Ngakhale palibe mankhwala a multiple sclerosis (MS) , pali mankhwala omwe angathandize kuchepetsa matendawa - mankhwalawa amatchedwa mankhwala ochiritsira matenda . Kuonjezerapo, pali mankhwala omwe angachepetse zizindikiro ndikuwongolera khalidwe la munthu tsiku ndi tsiku komanso ntchito yake.
Matenda ena a MS omwe amamva kuti ndi a cannabis, amadziwika kuti marijuana.
Tiyeni tiwone bwinobwino za momwe chiwopsezo chikugwiritsidwira ntchito mu MS, komanso kutsutsana kumeneku kuphatikizapo mankhwalawa.
Udindo wa Marijuana Pofuna Kuchita Zapadera mu MS
Nyamayi yayamba kale kugwiritsidwa ntchito mu MS kuti athetse vutoli , lomwe ndi chizindikiro chopweteka komanso chowawa kwambiri chomwe chimakhudza pafupifupi magawo awiri mwa atatu a anthu omwe ali ndi MS.
Kuthamanga kumatanthauza kuwonjezeka kwa minofu, kutanthauza kuti minofu inayake (makamaka miyendo) imakhala yovuta kupumula. Kuthamanga kungakhale koopsa, kumapangitsa kupweteka kwa minofu ndi kuuma kwachisoni, kupweteka kuyenda kapena zochitika zina, ndi kuchititsa kugwa.
Mwamwayi, mankhwala achikhalidwe omwe amachitira chithandizo chamtundu wa MS (mwachitsanzo, kuchepa kwa minofu, benzodiazepines, kapena anticonvulsants) nthawi zambiri sagwira ntchito bwino komanso amakhala ndi zotsatira monga kugona, zomwe zingawonongeke kutopa kwa MS- ndiwiri kawiri. Komanso, monga mankhwalawa, mankhwala osagwiritsa ntchito mankhwala ochizira matendawa (mwachitsanzo, mankhwala opangira thupi ndi mankhwala opangira magetsi) apezeka kuti ndi othandiza kwambiri.
Ichi ndichifukwa chake madokotala a MS atembenukira kuchipatala kuti athe kupereka chithandizo cha odwala awo.
Phunziro Loyamba pa Marijuana Chifukwa Chodziwika Kwambiri mu MS
Kafukufuku wina m'magazini ya Journal of Neurology, Neurosurgery, ndi Psychiatry anafufuza anthu pafupifupi 300 omwe ali ndi MS. Ophunzirawo anali ndi matenda osalimba kwa miyezi isanu ndi umodzi ndipo anafotokoza kupsinjika kwachisokonezo ndi kupitiriza kwa mimba kwa miyezi itatu asanalembetse kusukulu.
Gawo la ophunzira adalandira mankhwala osokoneza bongo (chamba) ndipo theka lina analandira malo a placebo. Ophunzira ndi ofufuzawo sanazindikire kuti adalandira ndani chamba cogonana ndi amene adalandira malowa, popeza zinthu zonsezi zinkaperekedwa kudzera mu kapupa wa gelatine.
Ophunzirawo amasonyeza zizindikiro zosiyanasiyana, monga mitsempha ya minofu, komanso momwe amachitira patsogolo asanafike kuchipatala ndipo kenako masabata khumi ndi awiri mutatha mankhwala (kapena placebo) adayamba.
Kupulumutsidwa kuumitsa mtima wamisala patatha masabata khumi ndi awiri kunachepa kawiri kawiri mu gulu la chamba ndi poyerekeza ndi gulu la placebo. Panalinso kusintha kwakukulu kwa minofu ya minofu ndi chisokonezo cha ogona kwa omwe adalandira chamba ndi anthu omwe adalandira malowa.
Zotsatira Zoipa
Ponena za chitetezo, zotsatira zowonongeka zinali zapamwamba kwambiri mu gulu lachiwonetsero cha khansa kusiyana ndi gulu la placebo, lomwe lili ndi chiwopsezo chachikulu cha zotsatira zovulaza zomwe zimachitika pamapeto a chiwerengero cha mlingo wa mankhwala omwe amatha kupitirira. Izi zinapangitsa kuti anthu azichotsa pa phunziroli.
Zina mwa zotsatira zovulaza zomwe zawonetsedwa pamwamba kwambiri mu chamba ca chamba ndi gulubo zikuphatikizapo:
- Chizungulire
- Kutopa
- Mlomo wouma
- Kufooka
Izi zidati, mavuto ambiri anali ofatsa kapena ocheperapo ndipo amachepetsedwa kwambiri pamapeto pa phunzirolo.
Phunziro lachiwiri pa Marijuana Gwiritsani Ntchito Zopatsa Thanzi mu MS
Mu phunziro lina, anthu omwe ali ndi MS apamwamba omwe sanagwiritse ntchito mankhwala ochiritsira ndi mankhwala a Sativex (nabiximol), opopera pakamwa omwe ali ndi tetrahydrocannabinol (THC) ndi cannabidiol (CBD), ndi mlingo uliwonse wa Sativex wopereka THC ndi CBD mu chiwerengero cha pafupi 1: 1.
Monga pambali, chamba chimachokera ku chitsamba cha Cannabis sativa, chomwe chimakhala ndi makumi asanu ndi limodzi kapena kuposerapo. Mwazinyalalazi, ziŵirizikulu ndizo THC ndi CBD, zonsezi zomwe zingathandize kuthetsa zofooka mwa kuchepetsa ululu ndi minofu yotsitsimula.
Ophunzirawo anayamba kuyesedwa kwa masabata 4, ndipo ngati atapindula ndi 20 peresenti kapena kupititsa patsogolo kwawo, iwo adapitiliza kuyesedwa kwa masabata 12. Pa yesewero ili lachiwiri, ophunzirawo adapatsidwa mwayi kuti alandire kapena kuti awapatse malo.
Zotsatira za phunziroli zinawulula kuti awo omwe analandira nabiximol anali ndi kusintha kwakukulu mwapadera mwachinyengo (kutanthauza kuti osachepera 30 peresenti yowonjezera kuchokera muyeso wawo) kusiyana ndi gulu la placebo. Panalinso zowonjezereka pafupipafupi komanso kusokonezeka kugona mu mankhwala osiyana ndi placebo.
Zotsatira Zoipa
Ndizoyenera kuzindikira kuti anthu 124 omwe adasunthira kumapeto kwa masabata 12 ndipo anapatsidwa maudindo, panali 15 okha omwe adasiya kuphunzira (gawo lochepa kwambiri kuposa maphunziro apamwamba). Izi zikhoza kukhala chifukwa chidziwitso cha mlingo wothandizira (kutanthauza kuti msanga wazitsamba unayamba kuchuluka bwanji) unali wochedwa komanso wochenjera.
Chimodzimodzinso, pangakhalenso mlingo wotsika wa zotsatira zoipa zomwe zafotokozedwa mu phunziroli-bonasi ina. Mwa iwo omwe adatenga nthendayi, zotsatira zowopsa kwambiri zinali:
- Vertigo
- Kutopa
- Mitundu ya misampha
- Matenda a m'matope
Uthenga wopita kunyumba kuchokera ku phunziroli ndikuti marijuana (chifukwa cha munthu woyenera, choncho "kuyesa kwa milungu isanu ndi itatu") amawoneka kuti ndi opindulitsa, otetezeka, komanso olekerera mu kanthawi kochepa pochiza matenda ochepa m'matenda ambiri.
Zomwe Maphunziro Amalonda Amanena
National MS Society imathandizira ufulu wa anthu kuti agwire ntchito ndi dokotala wawo wa MS kuti apeze chamba chifukwa cha mankhwala, "malinga ndi malamulo a m'mayiko omwe ntchito imeneyi yavomerezedwa." Komanso, National MS Society imathandizira kafukufuku omwe amawunikira phindu ndi zoopsa zogwiritsira ntchito chamba monga mankhwala kwa MS.
Izi zanenedwa, mwatsoka, kufufuza za chamba kugwiritsira ntchito mu MS nthawi zambiri kumaletsedwa chifukwa cha malamulo a boma, monga chigwirizano chiribe choletsedwa ku federal.
Malingana ndi National MS Society, maziko a udindo wawo pa chamba chimachokera ku lipoti la 2014 lofalitsidwa ndi American Academy of Neurology (AAN). Ndondomeko ya AAN imapereka njira zothandizira kugwiritsa ntchito mankhwala osiyanasiyana othandizira komanso ochiritsira opatsirana mu MS malinga ndi kufufuza kwa kafukufuku.
Pofuna kusuta chamba, AAN imasonyeza kuti kuchotsa mkaka wam'mimba ndi tetrahydrocannabinol (THC) kumathandiza kuchepetsa kupweteka komanso kupweteka.
Nthanoyo imanenanso kuti mankhwala otchedwa Sativex (naxibimol) omwe amatha kutulutsa pakamwa amatha kuwathandiza kuti apulumuke, amve kupweteka, ndi mafupipafupi; ngakhale Sativex salipo tsopano ku United States.
Kumbali ina, malinga ndi AAN, palibe umboni wokhudzana ndi sayansi kuti athetse phindu kapena chitetezo cha nthenda yotsekemera kuti apeze zizindikiro za MS.
Potsirizira pake, kuopsa koopsa kwa kugwiritsira ntchito mbuta pochiza zizindikiro zosiyanasiyana mu MS sikungodziwika panthawiyi chifukwa cha maphunziro ang'onoang'ono. Ndipotu, nkhawa yaikulu yokhudzana ndi kugwiritsira ntchito mbuta kwa nthawi yaitali ndizovuta kugwira ntchito, monga kukumbukira ndi kugwira ntchito.
Mawu Ochokera
Pogwiritsa ntchito mankhwala osokoneza bongo kuti agwiritse ntchito mankhwala osiyanasiyana m'mabuku makumi awiri mphambu asanu ndi anayi ndi District of Columbia (ndipo mwina akupita patsogolo), chiwerengero cha anthu omwe ali ndi MS omwe amatha kugwiritsa ntchito chamba kuti athetse zizindikiro zawo za MS zikhoza kuwuka.
Komabe, pofuna kudziwa kuti chitetezo chafupipafupi ndi chokhalitsa cha nthawi yayitali komanso chopindulitsa, ndikutonthozitsa nkhani, monga zizindikiro zomwe zimaperekedwa bwino ndi nthendayi kapena kuti mlingo kapena njira yoyendetsera bwino ndi yotani, tikufuna umboni wambiri wa sayansi.
Mpaka nthawiyo, ngati mukuganiza kuti chamba ndizovuta, chonde onetsetsani kuti mukuzigwiritsa ntchito motsogoleredwa ndi dokotala wanu wa MS . Mwanjira iyi, mungathe kupindula phindu lake ndikuchepetsa zotsatira zake zoipa. Kawirikawiri, izi zimaphatikizapo ndondomeko yoyamba chamba ndi ndondomeko yotsutsa.
> Zotsatira:
> Amatya B, Khan F, La Mantia L, Demetrios M, Wade DT. Osagwira ntchito zamagetsi kuti azitha kupezeka m'magulu osiyanasiyana. Cochrane Database Rev Rev 2013 Feb 28; (2): CD009974. lembani: 10.1002 / 14651858.CD009974.pub2.
> National MS Society. Marijuana yachipatala (Cannabis) FAQs.
> Novotna A et al. Gulu lopangidwa mozungulira, lopangidwa mobwerezabwereza, lopangidwa ndipadera, lofanana, lomwe limapangidwira maphunziro a nabiximols (Sativex (®), monga mankhwala owonjezera, pamutu ndi zowonongeka zomwe zimayambitsa matenda ambiri. Eur J Neurol . 2011 Sep; 18 (9): 1122-31. lembani: 10.1111 / j.1468-1331.2010.03328.x.
> Rudroff T, Woweruza JM. Nkhanza ndi multiple sclerosis-Njira yopita patsogolo. Kutsogolo Neurol. 2017; 8: 299.
> Zajicek JP, Hobart JC, Slade A, Barnes D, Mattison PG, MUSEC Research Group. Multiple sclerosis ndi kuchotsa nyamakazi: zotsatira za mayeso a MUSEC. J Neurol Neurosurg Psychiatry. 2012 Nov; 83 (11): 1125-32. lembani: 10.1136 / jnnp-2012-302468.