Kuwombera kwa Fecal microbiota (FMT) kukupitilizidwa ngati chithandizo chotheka cha matenda osiyanasiyana, makamaka matenda a Clostridium difficile . FMT ndi njira yowonjezera thanzi lachilombo kudzera m'kuyamba kwa nkhani yachinyama yomwe ili ndi mabakiteriya ambiri amtundu wathanzi . Pamene chidwi chapatsidwa kwa matope a bakiteriya ku IBS , zimawoneka ngati zachibadwa kukadzifunsa ngati FMT idzakhala mankhwala othandiza kwa IBS.
Tiyeni tiwone zomwe FMT ili, momwe izo zimagwirira ntchito, ndipo ndifukufuku ati awululira za ubwino wake kwa IBS.
FMT ndi chiyani?
FMT, yomwe imatchedwanso bacteriotherapy, ndi njira imene munthu wodwalayo amatha kupititsa m'mimba mwa munthu wodwalayo. Nthawi zambiri, kusamutsidwa kumeneku kumachitika pa colonoscopy ndondomeko, komanso mochepa mwa kugwiritsa ntchito enemas. Muzochitika zochepa, nkhaniyo ikhoza kusamutsidwa pogwiritsa ntchito chubu yamkati yomwe imalowa mumatumbo aang'ono .
FMT yakhala ikukondwera ndi kuvomereza kukhala njira yowonjezereka mwachindunji chifukwa cha mphamvu yake yochizira C kusiyana , komanso chifukwa chakuti asayansi akuyang'ana kwambiri pa ntchito yomwe matumbo a dysbiosis amavutitsa ku matenda ambiri. FMT imawoneka ngati yopambana ndi mankhwala opha tizilombo, maantibiobio, ndi maantibiobio kuti apangitse thanzi labwino, popeza kuti mankhwala amtundu wathanzi ali ndi mitundu yambiri ya "mabwenzi" omwe amapezeka bwino.
Kodi FMT Amachita Chiyani?
Monga tafotokozera pamwambapa, FMT yakhala njira yoyamba yothandizira C. kusiyana , makamaka pakakhala zochitika. Maphunziro a sayansi akuchitidwa kuti aone ngati FMT ndi mankhwala othandiza:
- Matenda opweteka m'magazi
- Matenda osokoneza bongo
- Matenda a shuga
- Matenda a zamadzimadzi
- Kunenepa kwambiri
Kodi Chimachitika Bwanji mu FMT?
FMT sangathe kuchitika popanda opereka ndalama.
Anthu amafufuzidwa kuti atsimikizire kuti ali ndi thanzi labwino. Opereka amapereka zitsulo zomwe zimagwiritsidwa ntchito pokonzekera njirayi. Zida zatsopanozi zimagwiritsidwa ntchito, ngakhale kuti kafukufuku wina akuchitidwa pazomwe zimagwira ntchito zowonongeka.
Monga tafotokozera pamwambapa, FMT ikhoza kuchitidwa kudzera mu colonoscopy, nasal tube, kapena enema. Chombo cha colonoscopy chimafuna chimodzimodzi " prep " monga chikhalidwe cha colonoscopy, kuti ayeretse colon.
Zotsatira za FMT ndizochepa zochepa zomwe zimakhala zochepa. Zotsatira zowonjezereka ndizosowa ndipo zimachitika mofanana ngati colonoscopy iliyonse, ndudu kapena njira ya enema.
Chifukwa chakuti wopereka mpando amachokera kwa munthu wina, pali zovuta zokhudzana ndi matenda opatsirana ndi opereka ndalama kuti alandire kupyolera mu chitseko (monga zopereka za mwazi, kusanakhwima kokwanira). Madokotala ndi ofufuza akukonza ndondomeko ndi machitidwe owonetsera pochepetsa chiopsezo ichi.
Kodi FMT Ingathandize IBS?
Lingaliro la FMT kwa IBS ndi lochititsa chidwi. Dysbiosis, chikhalidwe choipa cha m'matumbo tizilombo takhala tikugwirizanitsa ndi mavuto a motility ndi kutulukira kwa thupi lomwe limabweretsa zizindikiro za IBS. Ngati FMT ikanathandiza kukonza dysbiosis, zikanatsatira kuti odwala angachepetse zizindikiro.
Kafukufuku pa FMT kwa IBS ndiwokumbukira koma akulonjeza. Kafukufuku wochepa wokhudza odwala 13 okha omwe sanamvere mankhwala a IBS, adasonyeza kuti njirayi inathandiza kuchepetsa zizindikiro pa magawo awiri pa atatu alionse a ophunzira - ndi kusintha komwe kumawoneka mu zizindikiro zosiyanasiyana zomwe zimapanga IBS. Kafukufuku wina wasindikizidwa momwe odwala okwana 45 omwe anali ndi kudzimbidwa kosatha anachiritsidwa ndi FMT ndi fecal enema infusions. Otsutsa 89% mwa anthu omwe akugwira nawo ntchitowa amalephera kuchepetsa kudzimbidwa, kupweteka komanso kupweteka m'mimba. Odwala 30 anabwezeretsanso miyezi 9 mpaka 19 mutatha.
Mwa awa 30, 60% anali ndi zochitika zoyenera zojambula popanda kugwiritsa ntchito mankhwala osokoneza bongo.
Mfundo Yofunika Kwambiri
Panthawiyi, ndizoyambirira kwambiri mu masewerawa kuti atenge zowonjezereka za FMT kukhala njira yothandizira ya IBS. Zidzakhala zosangalatsa kuona ngati kafukufuku wamtsogolo akuthandizira kufufuza koyambirira kofufuza. Chofunika kukhala chotsimikizirika ndi chakuti ngati njirayi ikuthandizira kupindulitsa pazifukwa zina zothandizira chithandizo kuti zikhale zoyenera komanso kuti zitsimikizire kuti zilibe phindu lachidule kapena lalitali la chitetezo.
Zotsatira:
Aaronadis, O. & Brandt, L. "Intestinal Microbiota ndi Mphamvu ya Fecal Microbiota Transplantation mu Matenda Okhudza Mimba" Gastroenterology & Hepatology 2014 10: 230-237.
Wopanda, T., Brandt, L. & Paramsothy, S. "Kuchiza Mankhwala Osakaniza Madzi a Nkhono: Makhalidwe Amakono ndi Zamakono " Zomwe Zilipo Panopa mu Gastroenterology 2014 30: 97-105.
Odwala, T., Paramsothy, S. & Agrawal, G. "Fecal Microbiota Transplantation: Zizindikiro, Njira, Umboni, ndi Malangizo Atsogolomu" Mauthenga Amakono a Gastroenterology 2013 15: 337.
Malnick, S. & Melzer, E. "Mankhwala a Microbiome: Kuchokera M'nyumba ya Kugona mpaka Kumphepete" World Journal of Gastrointestinal Pathophysiology 2015 6: 79-85.
Rossen, N., et.al. "Fecal Microbiota Transplantation monga Thandizo Labwino mu Gastroenterology: Kukonzekera Kwambiri." World Journal of Gastroenterology 2015 21: 5359-5371.