Kuphatikizidwa Kwa Fecal Kungakhale Kuthandizira Kwambiri Kwa IBD?
Fecal bacteriotherapy (FB) kapena fecal microbiota transplantation (FMT) ndi mtundu wa mankhwala omwe wakhala akugwiritsidwa ntchito kwa zaka zambiri, koma tsopano wayamba kuyang'aniranso ntchito yake mu matenda opatsirana (inflammatory disease) (IBD) . Nthawi zina FB imagwiritsidwa ntchito pochiza matenda opatsirana ndi Clostridium difficile (kapena C difficile ), ngakhale kuti izi si zachilendo.
Mawu Olimba Ochenjeza
Kusintha kwa fecal sikuyenera kuchitidwa kunyumba , ngakhale mutatha kuwerenga malangizo kapena buku kapena kuyang'ana kanema ya momwe mungachitire.
Siyo "momwe" kuchita izo ndi gawo lovuta. Gawo lomwe likupitilizidwanso ndilopangitsa wopereka wabwino ndi momwe woperekayo amathandizira mabakiteriya kuti agwirizane ndikusintha mabakiteriya. Odwala amwalira atagwiritsira ntchito "zidziwitso". Ena adakumana ndi zotsatira zosayembekezereka monga matenda atsopano kapena kulemera. Thandizoli likupitilizidwanso kwa anthu omwe ali ndi IBD ndipo sizomwe zikuchitika kunyumba.
Fecal Bacteriotherapy Kwa C Difficile
Matumbo akuluakulu ali ndi mitundu yambiri ya mabakiteriya. Maonekedwe kapena chiwerengero cha mabakiteriya osiyanasiyana akhoza kusinthidwa ndi matenda kapena mankhwala. Matenda a C acile akhoza kuchitika pamene matenda a bakiteriya mumatumbo akulu amasintha (kawirikawiri ndi mankhwala opha tizilombo), zomwe zimapangitsa C difficile kufalikira ndi kubweretsa poizoni, zomwe zingayambitse kupweteka kwa matenda komanso kutsekula m'mimba.
Chithandizo cha matenda a C difficile ndi maphunziro a anti- C difficile masiku 10 mpaka 14. Nthaŵi zina, matenda a C difficile amatha kubwereranso pakatha mankhwalawa. Ndi chifukwa cha milandu iyi yomwe FB inakopa kwambiri.
FB ndi mankhwala opatsirana omwe sanayambe kugwiritsidwa ntchito kapena kuphunzira zambiri, koma ayesedwa ndi anthu ena omwe ali ndi matenda opatsirana a C difficile .
Njirayi imayambira ndi wachibale wapamtima amene ali wokonzeka kusonkhanitsa mpando wawo masiku angapo ndikupereka. Nkhani yamtunduwu imayesedwa pa chilichonse chimene chingawonongeke - monga matenda, mabakiteriya akunja kapena ma virusi . Pambuyo pachitetezo chotsimikizirika kukhala chosatetezeka kuti chimangidwe, chingagwiritsidwe ntchito kwa FB.
Momwe Fecal Bacteriotherapy Yachitira
Zinyamazo zimatha kuziika mwa wodwalayo kudzera mu enema , colonoscopy kapena nasogastric (NG) chubu . Ngati ataperekedwa ndi enema, nkhaniyi imasakanizidwa ndi madzi, monga saline, ndipo amapatsidwa ndi dokotala, kapena kunyumba ndi wachibale kapena wodwala mwiniwakeyo. Anema okha amapitirira mpaka m'koloni, kotero kuika palimodzi kudzera pa colonoscopy ndi njira ina yogwiritsiridwa ntchito. Pamene ndondomekoyi yachitidwa kudzera ku colonoscope, nkhani yachinyama ingathe kufalikira ponseponse, yomwe imaganiziridwa kukhala yothandiza kwambiri. Pamene tube ya NG (njira yofala kwambiri) imagwiritsidwa ntchito, zidazi zimatha kufalitsidwa m'mimba mwazing'ono komanso m'matumbo onse aakulu. Pulotoni-pump inhibitor nthawi zambiri amaperekedwa nthawi imodzimodziyo kuti ateteze mabakiteriya opindulitsa kuti asaphedwe ndi mimba.
Fecal Bacteriotherapy Kwa IBD
Imodzi mwa ziphunzitso zokhudzana ndi zomwe zingayambitse IBD zimaphatikizapo kusintha kwa mabakiteriya m'matumbo akuluakulu. Zikuganiziridwa kuti ngati anthu omwe ali ndi IBD alibe mabakiteriya m'thupi, kapena ambiri, FB ikhoza kukhala chithandizo chotheka. FB yakhala ikufufuzidwa kuti igwiritsidwe ntchito mu IBD muzing'onozing'ono, maphunziro oyambirira, kotero kuti mphamvuyo siinatsimikizidwebe. Chodetsa nkhaŵa kwambiri pa ntchito ya FB ndi chidwi cha anthu omwe ali ndi IBD kuti achite. Ofufuza ena anachita kafukufuku wochepa kuti aone ngati anthu omwe ali ndi zilonda zam'mimba angaganizire FB, ndipo lingalirolo linaperekedwa bwino.
Kuwonjezera apo: fecal microbiota transplantation (FMT)
Zotsatira:
Kahn SA, Gorawara-Bhat R, Rubin DT. "Fecal bacteriotherapy ya ulcerative colitis: Odwala ali okonzeka, kodi ifeyo?" Chifuwa cha Inflamm May 25 May 2011 KODI: 10.1002 / ibd.21775. 31 Jul 2013.
Wopanda TJ, Warren EF, Leis S, Surace R, Ashman O. "Kuchiza kwa ulcerative colitis pogwiritsa ntchito bacteriotherapy". J Clin Gastroenterol 2003 Jul; 37: 42-47. 31 Jul 2013.