Kodi umboni wamakono umathandizira?
Kodi n'zotheka kuti mankhwala omwe amachiritsira opioid ndi mowa amatha kusintha moyo ndi maganizo a anthu omwe ali ndi multiple sclerosis (MS) ?
Kafukufuku wina akusonyeza kuti zingatheke. Ngakhale kuti sakuvomerezedwa kuti agwiritsidwe ntchito, mlingo wochepa wotchedwa naltrexone (LDN) ukuwonjezeredwa kuchoka pamalopo kuti athetse kufooka kwa MS, chizoloŵezi chodziwika komanso chothetsa nzeru cha matendawa.
Kugwiritsidwa Ntchito kwa Naltrexone
Naltrexone inavomerezedwa ndi US Food and Drug Administration mu 1984 pofuna kuchiza opioid mowa ndipo mu 1994 kuti athetse vuto la kumwa mowa (AUD). Pa mlingo wokwanira wokwanira (50 mpaka 100 milligram patsiku), naltrexone imachepetsa zotsatira za opioid ndi kuchepetsa chikhumbo cha munthu kuti amwe.
Mu mphamvu zonsezi, naltrexone yasonyezedwa kuti imapereka modzichepetsa ku zotsatira zosavuta pochiritsa Kuonjezera koma zingakhale zopindulitsa zikagwiritsidwa ntchito monga gawo la dongosolo lochiritsidwa la mankhwala.
Kuchotsa Mtsuko Kugwiritsa Ntchito Naltrexone
Pa nthawi yomwe naltrexone inayamba kukonzedwa, ofufuza a Penn State College of Medicine anayamba kuphunzira momwe amagwiritsira ntchito pochiza matenda omwe amachititsa kuti thupi lawolo lisamangidwe.
Ambiri a sclerosis amakhulupirira kuti ambiri amayambitsidwa ndi yankho lokhalokhalokha ndipo anali mmodzi mwa oyambirira kukafufuza. Zimene ofufuza adazipeza ndikuti kuchepa kwa mankhwala osokoneza bongo kunalimbikitsa kupanga hormone endorphin, zomwe zimapangitsa kuchuluka kwa mphamvu ndi mphamvu zotsutsana ndi zotupa.
Zili zofanana ndi zomwe zimachitika pa nthawi ya mimba komwe kuwonjezeka kwa endorphin kupanga komwe kumakhudzana ndi nthawi yowonjezera MS.
Ngakhale kuti sipadzakhalanso umboni wovuta wa kuchipatala kuti athandizidwe, akatswiri ena amakhulupirira kuti LDN ikhoza kuchepetsa kuchuluka kwa mphamvu za MS zomwe zimakhala ngati kutopa, kupweteka, kuperewera , kusokonezeka maganizo , ndi kupsinjika maganizo .
Malingaliro a Chithandizo
Ngati atapatsidwa mankhwala ochepa (osachepera 10 peresenti ya omwe amagwiritsa ntchito mankhwala osokoneza bongo), LDN imatengedwa kuti ndi yotetezeka komanso yosamalidwa bwino.
Mlingo umene anthu ambiri omwe ali ndi MS amakhala nawo kuyambira 1.5 milligrams mpaka 4.5 milligrams pa tsiku. Amalangizidwa kuti anthu omwe ali ndi mtundu wina uliwonse wonyalanyaza amatenga ma milligrams osachepera tsiku lililonse chifukwa angapangitse kuuma kwa minofu.
LDN ikhoza kutengedwa kapena wopanda chakudya koma iyenera kutengedwa pakati pa 9 koloko masana ndi pakati pausiku kuti iyanjanitse ntchito ya chilengedwe chachilengedwe endorphin kumasulidwa.
Zotsatira zofala kwambiri za LDD ndi maloto omveka omwe amatha kukhala pansi pamapeto pa sabata yoyamba kapena iwiri. Kawirikawiri, kukwiya kumadziwika kuti kumachitika.
Zomwe zimagwiritsidwa ntchito komanso kutsutsana
Chimodzi mwa mikangano yaikulu mu kugwiritsira ntchito LDN ndiko kugwirizana kwake ndi mankhwala ambiri osokoneza matenda omwe amagwiritsidwa ntchito pochiza MS. Malinga ndi mankhwala a mankhwala osokoneza bongo, LDN sayenera kugwiritsidwa ntchito ndi Avonex , Rebif , kapena Betaseron . Mosiyana ndi izo, zikuwoneka kuti palibe kutsutsana ndi Copaxone .
Chifukwa chakuti amachotsedwa kuchokera ku thupi kudzera m'chiwindi, LDN sichivomerezedwa kwa anthu omwe ali ndi chiwindi, chiwindi, kapena chibwibwi.
LDN sayenera kuphatikizidwa ndi mankhwala aliwonse opiate opiate kuphatikizapo Oxycontin (oxycodone), Vicodin (hydrocodone) .modzinso ma code symps.
Kuwongolera Umboni Wamakono
Ngakhale kuvomerezana kwakukulu kungasonyeze kuti LDN imathandiza kuti thanzi labwino likhale labwino ndi anthu omwe ali ndi MS, umboni weniweniwo wasokonezedwa. Mwa iwo:
- Kafukufuku woyendetsa ndege ku University of California ku San Francisco anaphatikizapo anthu 80 omwe ali ndi MS omwe anachitidwa ndi LDN masabata asanu ndi atatu. Ngakhale kuti LDN siinasinthe kagwiritsidwe ka ntchito kapena mphamvu za ophunzirawo, izi zinapangitsa kuti kusintha kwakukulu kukhale kofunika kwambiri m'moyo wawo (kuphatikizapo kuchepetsa ululu ndi kuvutika maganizo komanso kuwonjezeka kwa chidziwitso).
- Mlandu wa Phase II womwe unachitikira ku Italy mu 2008 unayang'ana anthu 40 omwe ali ndi MS apamwamba pa chithandizo cha LDN kwa miyezi isanu ndi umodzi. Pamapeto pake panali kusintha kwa chiwerengero cha anthu ambiri (47 peresenti yowonjezereka, 11 peresenti yowonjezereka) koma palibe kusintha kwachisokonezo (56 peresenti yowonjezereka, 33 peresenti yowonjezereka) kapena kutopa (33 peresenti yawonjezeka, 41 peresenti yowonjezereka). Mosiyana ndi zimenezi, LDN inagwirizanitsidwa ndi zowawa zowonjezereka (28 peresenti inawonjezeka, 56 peresenti yaipiraipira).
- Phunziro la ma sabata 17, lomwe linayang'aniridwa mwachidziwitso, silinapeze kusiyana kwa chiwerengero pakati pa anthu omwe amatenga LDN kapena placebo kapena kusintha kulikonse kwa moyo, kuphatikizapo kupweteka, mphamvu, kulingalira, komanso kukhala ndi moyo wabwino.
> Zosowa
> Cree, B .; Kornyeyeva, E .; ndi Goodin, D. "Mayeso oyendetsa a dose naltrexone ndi khalidwe la moyo mu multiple sclerosis." Annals Neurol . 2010; 68 (2): 145-150.
> Gironi, M .; Martinelli-Boneschi, F .; Sacerdote, P. et al. "Mayesero oyendetsa galimoto a dose ochepa amatha kusokonezeka kwambiri m'magazi enaake oyamba." Mult Scler . 2008; 14 (8): 1076-83.
> Sharaaddinzadeh, N .; Moghtederi, A .; Kashipazha, D. et al. "Zotsatira za mlingo wazitali zimapangitsa kuti munthu akhale ndi moyo wathanzi wa odwala matenda osiyanasiyana. Mult Scler. 2010; 16 (8): 964-9.