Mankhwala, Kusintha kwa Moyo Kumadalira Chiwerengero cha Chizindikiro
Kuchiza kwa matenda osapuma (RLS) kumadalira nthawi zambiri pa zizindikiro komanso pali njira zambiri, kuphatikizapo mankhwala komanso kusintha kwa moyo. Pofuna kusankha chithandizo choyenera, muyenera kudziwa ngati zizindikiro zanu zimakhala zochepa, tsiku ndi tsiku, kapena zotsutsa mankhwala. Kawirikawiri, iwo omwe ali ndi zizindikiro zosiyana-siyana ayenera kugwiritsa ntchito kusintha kwa moyo wawo, mankhwala omwe amakhudza ma dopamine, ma opioids ochepa, kapena benzodiazepines.
Ngati zizindikiro zili tsiku ndi tsiku, gabapentin ikhoza kukhala njira yowonjezera. Pomaliza, ngati muli ndi zizindikiro zomwe sizikugwirizana ndi mankhwala, muyenera kuyesa mankhwala osiyana kapena achiwiri.
Mankhwala Osokoneza Bongo
Njira yoyamba yothetsera vuto la miyendo yopanda phokoso ndi mankhwala omwe angakhudze ma dopamine. Izi zikhoza kuchitidwa mwachindunji dopamine m'malo mwake (ndi mankhwala otchedwa levodopa) kapena ndi mankhwala omwe amachulukitsa miyendo yanu ya dopamine mwa kusintha momwe thupi likugwiritsira ntchito. Levodoopa ali ndi zotsatira zoyipa, kuphatikizapo kunyozetsa, kufooka, ndi kugona. Kuonjezera apo, levodopa ikhoza kutsogolera kuwonjement, momwe zizindikiro zingayambire msana masana, zimakhala zovuta kwambiri, kapena zimafalikira m'manja. Izi zikhoza kuchitidwa mwa kuwonjezera mlingo wammbuyo, koma ngati ukupitirizabe levodopa ayenera kuimitsidwa kapena mlingo umachepetsedwa. Chifukwa cha mavutowa, mankhwala omwe amatchedwa dopamine agonists nthawi zambiri amawakonda.
The dopamine agonists ndi mankhwala monga pramipexole (dzina lachizindikiro Mirapex) ndi ropinirole (dzina lachidziwitso) . Izi sizikuwopsa kwambiri monga zotsatira. Pakhoza kukhala kupsinjika pang'ono ndi kutopa, koma izi kawirikawiri zimatsimikizira patapita milungu ingapo ya chithandizo. Zotsatira zochepa chabe zomwe zimakhalapo zimaphatikizapo nsanza, kudzimbidwa, kusowa tulo , ndi edema ya mwendo.
Kuwonjezera apo, pali kuthekera kwa kuwonjezeka kwa chiopsezo cha kusokonezeka mwadzidzidzi komwe kungaphatikize kutchova njuga, kukakamiza kudya kapena kugula, kapena kugonana kosayenera.
Palinso mankhwala ena atatu omwe sagwiritsidwa ntchito kwambiri omwe angakhudze ma dopamine omwe amatchedwa bromocriptine, per gold, ndi cabergoline. Izi sizimagwiritsidwa ntchito nthawi zambiri chifukwa cha zovuta (koma zingakhale zovuta) kuphatikizapo fibrosis (scarring) ya valves yamtima. Chifukwa cha mavutowa, phindu silipezeka ku United States. Cabergoline sichivomerezedwa ndi FDA kuti chigwiritsidwe ntchito kwa RLS, koma nthawi zina amagwiritsidwa ntchito kunja kwa tepi pazinthu izi. Zingayambitse kunyowa, kudzimbidwa, kumutu, chizungulire, kutopa, kapena kugona.
Opioids
Mankhwala opioid amagwiritsidwa ntchito nthawi zambiri kuti athetse ululu wochepa, koma angathandizenso kuchiza RLS. Zina mwazogwiritsidwa ntchito kwambiri zimaphatikizapo oxycodone, codeine, ndi methadone. Kawirikawiri amapatsidwa mankhwala osagawanika tsiku lonse kuti athetse zizindikiro za RLS. Mosiyana ndi ntchito ya opioid mukumva kupweteka, pali chiwopsezo chodabwitsa chokwanira kapena cholekerera pamene chigwiritsidwe ntchito kuchiza RLS. Kugonjetsa kungabwere, koma kawirikawiri ndizochepa.
Monga mankhwalawa amadzichepetsa kupuma, kugwiritsa ntchito moyenera kumalangizidwa ngati muli ndi vuto la kugona . Ma opioids amagwiritsidwa ntchito mwa anthu omwe amalephera kulandira mankhwala ena.
Gabapentin
Ngati zizindikiro za RLS zimachitika tsiku lililonse kapena zosagwirizana ndi mankhwala ena, kugwiritsa ntchito gabapentin kungagwiritsidwe ntchito. Nthaŵi zina Gabapentin amagwiritsidwa ntchito pofuna kupweteka kapena kupweteka kwa mtima, koma imathandizanso ku RLS. Amapatsidwa mankhwala osagawanika tsiku lonse. Zimayambitsa kusakhazikika poyenda kapena kugona. Zingakhale zothandiza makamaka ngati ululu umayesedwa ndi zizindikiro za RLS.
Benzodiazepines
Kalasi ya mankhwala yotchedwa benzodiazepines nthawi zambiri imathandiza m'zigawo zochepa za RLS, makamaka pakati pa achinyamata.
Ngati muli ndi zizindikiro za pakati, zingakhale bwino. Omwe amagwiritsidwa ntchito kwambiri ndi clonazepam ndi diazepam. Kusokonezeka kwa mwendo kumakhala kochepa, koma kungathandize kuti munthu asagone. Mankhwalawa amachititsa kuti munthu asagonje, asagone, kapena asaganizire.
Njira Zochiritsira Zopangira RLS
Ngati mwapezeka kuti mulibe chitsulo pa kafukufuku woyamba wa chifukwa cha zizindikiro zanu za RLS, kusinthanitsa chitsulo kungakhale mankhwala othandiza. Komatu sizingagwiritsidwe ntchito ngati mankhwala anu okha. Pogwiritsira ntchito mankhwala odzola, mankhwala a vitamini C angakuthandizeni kuchepetsa kumwa.
Pali zinthu zina zomwe zingakuthandizeni kusintha malingaliro anu a RLS. Izi zimaphatikizapo kuchita maseŵera olimbitsa thupi musanagone. Kuonjezera apo, kudzipangitsa nokha kugwiritsidwa ntchito m'maganizo mwathu kungachepetse zizindikiro. Izi zingaphatikizepo kusewera masewera a pakompyuta kapena kupanga crossword puzzles.
Pomaliza, muyenera kupewa zinthu zomwe zingapangitse zizindikiro zanu za RLS. Caffeine, chikonga, ndi mowa zingathe kuwononga zizindikiro zanu. Kuwonjezera apo, mankhwala ena ophera kupatsirana, antiemetetic, monga antibiotic, ndi antihistamines ayenera kupeŵedwanso pamene angawonjezere RLS.
Zotsatira
Chaudhuri, KR. "Matenda a miyendo yopanda mapeto." N Engl J Med 2003; 349: 815.
Silber, MH et al . "Chizoloŵezi choyang'anira matenda osapumitsa miyendo." Mayo Clin Proc 2004; 79: 916.
Madzi, AS. "Matenda a miyendo yopanda mpumulo komanso kusuntha kwa magetsi nthawi yogona." Kupitiriza. Neurol 2007; 13 (3): 115-138.